BACTRIM IV SUMMARY
Bactrim (trimethoprim and sulfamethoxazole) IV Infusion, a sterile solution
for intravenous infusion only, is a synthetic antibacterial combination product.
Pneumocystis Carinii Pneumonia: Bactrim IV Infusion is indicated in
the treatment of Pneumocystis carinii pneumonia in children and adults.
Shigellosis: Bactrim IV Infusion is indicated in the treatment
of enteritis caused by susceptible strains of Shigella flexneri and Shigella
sonnei in children and adults.
Urinary Tract Infections: Bactrim IV Infusion is indicated
in the treatment of severe or complicated urinary tract infections due to susceptible
strains of Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii and Proteus species when oral administration
of Bactrim is not feasible and when the organism is not susceptible to single-agent
antibacterials effective in the urinary tract.
Although appropriate culture and susceptibility studies should be performed,
therapy may be started while awaiting the results of these studies.
Published Studies Related to Bactrim IV (Trimethoprim and Sulfamethoxazole)
Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin
community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is unclear... CONCLUSIONS: We found no significant difference between clindamycin and TMP-SMX,
Itraconazole vs. trimethoprim-sulfamethoxazole: A comparative cohort study of 200
patients with paracoccidioidomycosis. 
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Brazil accounts for approximately 80% of cases, where it represents a major
public health issue due to its disabling impact and the number of premature
deaths it causes... Although the results of this study show that
itraconazole was the best treatment option for PCM patients, a double-blind,
randomized, controlled trial is necessary to confirm this conclusion.
Short- and long-term cure rates of short-duration trimethoprim-sulfamethoxazole
treatment in female dogs with uncomplicated bacterial cystitis. 
BACKGROUND: Long-duration beta-lactam antibiotics are used for empirical
treatment in female dogs with uncomplicated bacterial cystitis. However, women
with bacterial cystitis are treated with short-duration potentiated sulfonamides
because longer courses of beta-lactams result in lower cure and higher recurrence
Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. [2010.09]
STUDY OBJECTIVE: Community-associated methicillin-resistant Staphylococcus aureus is now the leading cause of uncomplicated skin abscesses in the United States, and the role of antibiotics is controversial. We evaluate whether trimethoprim-sulfamethoxazole reduces the rate of treatment failures during the 7 days after incision and drainage and whether it reduces new lesion formation within 30 days... CONCLUSION: After the incision and drainage of uncomplicated abscesses in adults, treatment with trimethoprim-sulfamethoxazole does not reduce treatment failure but may decrease the formation of subsequent lesions. Copyright (c) 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.
Standard versus newer antibacterial agents in the treatment of severe acute exacerbation of chronic obstructive pulmonary disease: a randomized trial of trimethoprim-sulfamethoxazole versus ciprofloxacin. [2010.07.15]
BACKGROUND. Although the use of antibiotics in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) is largely accepted, controversy remains regarding whether the choice of antibiotic has any impact on outcome.
Clinical Trials Related to Bactrim IV (Trimethoprim and Sulfamethoxazole)
Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole [Recruiting]
First study to test the validity of the treatment of idiopathic pulmonary fibrosis, which
causes inflammation and fibrosis (scarring) of the lung tissue, with cotrimoxazole.
Cotrimoxazole may improve the clinical course of the disease through eradication of
Pneumocystis jiroveci colonization and other mechanisms as inhibiting the activation of
alveolar macrophages and producing alterations in the surfactant system which favours the
persistent activation of the inflammatory response and the development of pulmonary
Safety of Cotrimoxazole in HIV- and HAART-exposed Infants [Completed]
PK of Clindamycin and Trimethoprim-sulfamethoxazole in Infants and Children [Not yet recruiting]
Developmental changes in physiology during childhood influence drug dosing. Failure to
account for these changes leads to improper dosing, which is associated with decreased drug
efficacy and safety in children. Population physiologically-based pharmacokinetic (PBPK)
modeling offers the opportunity to predict optimal drug dosing based on physiologic
parameters adjusted for developmental changes.
PBPK models are mathematical constructs that incorporate physiologic processes with drug
characteristics and genetic variances to characterize the dose-exposure relationship across
the age continuum. These models integrate drug-specific (e. g., metabolism, protein binding)
and systems-specific (e. g., organ size, blood flow) information to predict the effect of
different factors (e. g., age, genetic variants, disease) on drug exposure. By accounting
for these factors and using data from clinical trials to confirm the modeling, PBPK models
can reduce the number of children needed for clinical trials while maximizing dose-based
efficacy and safety.
This trial will evaluate a platform to prospectively validate population PBPK models in
children. The study drugs, clindamycin and Bactrim (aka TMP-SMX), are ideal candidates to
evaluate population PBPK models in children due to their differing physico-chemical
properties and elimination pathways. In addition, a trial of clindamycin and TMP-SMX has
broad clinical applicability, as both drugs are among the most commonly used agents to treat
gram-positive infections in infants and children.
Cotrimoxazole Versus Amoxicillin in the Treatment of Community Acquired Pneumonia in Children Aged 2-59 Months [Completed]
The investigators hypothesized that Oral amoxicillin (25mg/kg/dose bid) given to children
aged 2-59 months with pneumonia, would lead to better clinical outcome on day three in
89. 9% of the children compared to 77. 0% of children receiving oral cotrimoxazole (8
mg/kg/dose trimethoprim, 40 mg/kg/dose sulphamethoxazole). A double blind randomized
controlled trial was conducted in the Assessment Center of Mulago Hospital. Children with
non-severe pneumonia were randomized to receive either oral amoxicillin (25 mg/kg/dose) or
cotrimoxazole (trimethoprim 8 mg/kg and sulphamethoxazole 40 mg/kg) and followed up on day 3
and 5 of treatment. The primary outcome measures were normalization of respiratory rate by
day 3 of treatment. Secondary outcome measures were antimicrobial susceptibility to
cotrimoxazole and amoxicillin.
Study of New Antibiotic Regimen for the Treatment of Uncomplicated Cellulitis in Emergency Department Patients [Completed]
The primary aim of this study is to quantify the effectiveness of Bactrim as additional
therapy for the treatment of uncomplicated cellulitis in adults, by comparing: standard
therapy plus Bactrim, versus standard therapy plus placebo.
The primary hypothesis of this study is that, in light of increasing CA-MRSA prevalence,
subjects treated with standard therapy plus Bactrim will have higher cure rates than those
treated with standard therapy plus placebo.
Page last updated: 2015-08-10