Nephrotoxicity: Bacitracin in parenteral (intramuscular) therapy may cause renal failure due to tubular and glomerular necrosis. Its use should be restricted to infants with staphylococcal pneumonia and empyema when due to organisms shown to be susceptible to bacitracin. It should be used only where adequate laboratory facilities are available and when constant supervision of the patient is possible.
Renal function should be carefully determined prior to and daily during therapy. The recommended daily dose should not be exceeded and fluid intake and urinary output should be maintained at proper levels to avoid kidney toxicity. If renal toxicity occurs the drug should be discontinued. The concurrent use of other nephrotoxic drugs, particularly streptomycin, kanamycin, polymyxin B, polymyxin E (colistin), neomycin, and vancomycin, should be avoided.
The vial content of Bacitracin for Injection USP is sterile. The therapeutic class of the drug is antibacterial and is intended for intramuscular use.
BACiiM (Bacitracin) is indicated for the following:
In accord with the statements in the “ Warning Box ” the use of intramuscular bacitracin is limited to the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of bacitracin and other antibacterial drugs, bacitracin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Media Articles Related to Baciim (Bacitracin)
Liver plays role in pneumonia, sepsis susceptibility
Source: Respiratory / Asthma News From Medical News Today [2015.07.31]
New evidence highlights the importance of the liver in immunity against bacterial pneumonia.
An Optimal Therapy for Community-Acquired Pneumonia?
Source: Medscape Critical Care Headlines [2015.07.30]
Dr Andrew Shorr reviews a recent trial that seeks to find an optimal treatment for patients who have been hospitalized with community-acquired pneumonia.
Medscape Pulmonary Medicine
Aerosolized Colistin for Ventilator-Associated Pneumonia
Source: Medscape Pharmacists Headlines [2015.07.30]
What is the optimal dosing regimen for nebulized colistin in patients with multidrug-resistant ventilator-associated pneumonia?
New CDC study highlights burden of pneumonia hospitalizations among US adults
Source: Respiratory / Asthma News From Medical News Today [2015.07.15]
When U.S. adults are hospitalized with pneumonia, viruses are more often to blame than bacteria.
Pneumonia investment doesn't match mortality burden
Source: Respiratory / Asthma News From Medical News Today [2015.07.15]
Research spend still relatively low, despite recent risesUK investment in pneumonia research is lacking when compared to spending on influenza and tuberculosis, according to a new study by...
Published Studies Related to Baciim (Bacitracin)
Effects of feeding diets containing bacitracin methylene disalicylate to heat-stressed finishing pigs. [2011.06]
The objective of this study was to evaluate the effects of heat stress and dietary bacitracin methylene disalicylate (BMD) on growth performance, carcass characteristics, and immunological responses in finishing pigs. Four groups of 32 finishing pigs (n = 128) with initial BW between 80 to 90 kg were used...
Effects of dietary mannan oligosaccharide, bacitracin methylene disalicylate, or both on the live performance and intestinal microbiology of turkeys. [2004.07]
Hybrid male turkeys were fed to 18 wk of age in a completely randomized design with 10 replicate pens (18 birds each) per treatment to compare growth promoters. Four dietary treatments were used: negative control (CON), bacitracin methylene disalicyate (BMD) at 55 mg/kg to 6 wk and 27.5 mg/kg thereafter, mannan oligosaccharide (MOS) at 0.1% to 6 wk and 0.05% thereafter, and BMD and MOS at concentrations listed above...
The efficacy of bacitracin methylene disalicylate when fed in combination with narasin in the management of necrotic enteritis in broiler chickens. [2003.03]
The efficacy of bacitracin methylene disalicylate (BMD) in the management of necrotic enteritis (NE) when fed in combination with narasin was investigated in a floor-pen study of 2,000 broiler chickens using a Clostridium perfringens inoculum challenge model.
Evaluation of zinc bacitracin capsules versus placebo for enteric eradication of vancomycin-resistant Enterococcus faecium. [2001.08.15]
Patients who are colonized with enteric vancomycin-resistant Enterococcus faecium (VREF) are a major reservoir for transmission of and infection with this organism. In a randomized, controlled study to assess the effectiveness of high-dose bacitracin in the eradication of enteric VREF, 12 patients who were colonized with VREF were randomized to receive placebo (n=6) or orally administered zinc bacitracin (n=6) for 10 days...
Bacitracin versus mupirocin for Staphylococcus aureus nasal colonization. [1999.05]
We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S...
Clinical Trials Related to Baciim (Bacitracin)
Clinical Evaluation of Bacitracin [Completed]
The Relationship of Hemoglobin A1c and Diabetic Wound Healing [Not yet recruiting]
The purpose of this study is to investigate the relationship of hemoglobin A1c in diabetic
wound healing. Additionally, a comparison of two wound dressings, AmeriGel® (Amerx Health
Care Corp., Clearwater, FL) and Bacitracin, with and without vitamin C supplementation, will
be done to evaluate impact on time to wound closure.
Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge [Recruiting]
This study will evaluate the efficacy of a nasopore sponge dressing soaked in Bacitracin VS
a sponge soaked in Saline / and the administration of oral antibiotics.
Nasospore Stent For Use in Enodscopic Sinus Surgery [Recruiting]
The purpose of this study is to evaluate a stenting material called Nasopore. This is a
synthetic material approved by FDA for use as a stent in postoperative sinus surgery
patients. This study will compare the Nasopore stent to other approved stenting materials.
Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients [Not yet recruiting]
This study will investigate how the use of Tranexamic acid and Bacitracin applied to the
bleeding site after the hemodialysis fistula needle is removed will affect skin wound
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Baciim has an overall score of 5. The effectiveness score is 2 and the side effect score is 4. The scores are on ten point scale: 10 - best, 1 - worst.
Baciim review by care giver of 28 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || simple laceration|
|Dosage & duration:|| || ointment (dosage frequency: topically applied once) for the period of once|
|Other conditions:|| || NONE KNOWN|
|Other drugs taken:|| || NONE|
|Benefits:|| || THIS IS A WIDELY USED COMMON ANTIBIOTIC OINTMENT FOR SUPERFICIAL LACERATIONS|
|Side effects:|| || A FULMINATING ALLERGIC REACTION|
|Comments:|| || YOUNG MALE WORKING IN A FACTORY CAME TO HEALTH CLINIC WITH A SUPERFICIAL LACERATION ON HIS FINGER - AFTER CLEANSING THE AREA WITH SOAP WATER PEROXIDE BACITRACIN AND A CLEAN DRY DRESSING APPLIED. WORKER CAME BACK THE FOLLOWING DAY WITH THE FINGER SWOLLEN 2XS AND NOW WOUND ENLARGED AND DRAINING. SENT TO ER FOR F/UP TX OF STEROIDS.|
Page last updated: 2015-07-31