Nephrotoxicity: Bacitracin in parenteral (intramuscular) therapy may cause renal failure due to tubular and glomerular necrosis. Its use should be restricted to infants with staphylococcal pneumonia and empyema when due to organisms shown to be susceptible to bacitracin. It should be used only where adequate laboratory facilities are available and when constant supervision of the patient is possible.
Renal function should be carefully determined prior to and daily during therapy. The recommended daily dose should not be exceeded and fluid intake and urinary output maintained at proper levels to avoid kidney toxicity. If renal toxicity occurs the drug should be discontinued. The concurrent use of other nephrotoxic drugs, particularly streptomycin, kanamycin, polymyxin B, polymyxin E (colistin), neomycin, and viomycin, should be avoided.
Bacitracin for Injection USP
The vial content of Bacitracin for Injection USP is sterile. The therapeutic class of the drug is antibacterial and is intended for intramuscular use.
BACiiM (Bacitracin) is indicated for the following:
In accord with the statements in the “ Warning Box ” the use of intramuscular bacitracin is limited to the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of bacitracin and other antibacterial drugs, bacitracin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Media Articles Related to Baciim (Bacitracin)
Brazilian study suggests adjustments on the treatment of cancer patients with pneumonia
Source: Respiratory / Asthma News From Medical News Today [2015.04.14]
Cancer patients are more vulnerable to severe pneumonia, but the standard broad-spectrum antibiotic treatment used by physicians worldwide may not be the better choice for this groupCancer...
Simple antibiotic strategy is sufficient for treating pneumonia
Source: Respiratory / Asthma News From Medical News Today [2015.04.09]
Patients with pneumonia can initially be treated with most common antibiotics.
Is Pneumonia Contagious?
Source: MedicineNet Chronic Cough Specialty [2015.04.07]
Title: Is Pneumonia Contagious?
Category: Diseases and Conditions
Created: 4/7/2015 12:00:00 AM
Last Editorial Review: 4/7/2015 12:00:00 AM
Common Class of Drugs May Be Linked to Pneumonia Risk
Source: MedicineNet doxepin Specialty [2015.03.04]
Title: Common Class of Drugs May Be Linked to Pneumonia Risk
Category: Health News
Created: 3/3/2015 12:00:00 AM
Last Editorial Review: 3/4/2015 12:00:00 AM
Viruses Increasingly Behind Child Pneumonia Cases
Source: MedicineNet Chickenpox (Varicella) Specialty [2015.02.26]
Title: Viruses Increasingly Behind Child Pneumonia Cases
Category: Health News
Created: 2/25/2015 12:00:00 AM
Last Editorial Review: 2/26/2015 12:00:00 AM
Published Studies Related to Baciim (Bacitracin)
Effects of feeding diets containing bacitracin methylene disalicylate to heat-stressed finishing pigs. [2011.06]
The objective of this study was to evaluate the effects of heat stress and dietary bacitracin methylene disalicylate (BMD) on growth performance, carcass characteristics, and immunological responses in finishing pigs. Four groups of 32 finishing pigs (n = 128) with initial BW between 80 to 90 kg were used...
Effects of dietary mannan oligosaccharide, bacitracin methylene disalicylate, or both on the live performance and intestinal microbiology of turkeys. [2004.07]
Hybrid male turkeys were fed to 18 wk of age in a completely randomized design with 10 replicate pens (18 birds each) per treatment to compare growth promoters. Four dietary treatments were used: negative control (CON), bacitracin methylene disalicyate (BMD) at 55 mg/kg to 6 wk and 27.5 mg/kg thereafter, mannan oligosaccharide (MOS) at 0.1% to 6 wk and 0.05% thereafter, and BMD and MOS at concentrations listed above...
The efficacy of bacitracin methylene disalicylate when fed in combination with narasin in the management of necrotic enteritis in broiler chickens. [2003.03]
The efficacy of bacitracin methylene disalicylate (BMD) in the management of necrotic enteritis (NE) when fed in combination with narasin was investigated in a floor-pen study of 2,000 broiler chickens using a Clostridium perfringens inoculum challenge model.
Evaluation of zinc bacitracin capsules versus placebo for enteric eradication of vancomycin-resistant Enterococcus faecium. [2001.08.15]
Patients who are colonized with enteric vancomycin-resistant Enterococcus faecium (VREF) are a major reservoir for transmission of and infection with this organism. In a randomized, controlled study to assess the effectiveness of high-dose bacitracin in the eradication of enteric VREF, 12 patients who were colonized with VREF were randomized to receive placebo (n=6) or orally administered zinc bacitracin (n=6) for 10 days...
Bacitracin versus mupirocin for Staphylococcus aureus nasal colonization. [1999.05]
We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S...
Clinical Trials Related to Baciim (Bacitracin)
Clinical Evaluation of Bacitracin [Completed]
The Relationship of Hemoglobin A1c and Diabetic Wound Healing [Not yet recruiting]
The purpose of this study is to investigate the relationship of hemoglobin A1c in diabetic
wound healing. Additionally, a comparison of two wound dressings, AmeriGel® (Amerx Health
Care Corp., Clearwater, FL) and Bacitracin, with and without vitamin C supplementation, will
be done to evaluate impact on time to wound closure.
Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge [Recruiting]
This study will evaluate the efficacy of a nasopore sponge dressing soaked in Bacitracin VS
a sponge soaked in Saline / and the administration of oral antibiotics.
Nasospore Stent For Use in Enodscopic Sinus Surgery [Recruiting]
The purpose of this study is to evaluate a stenting material called Nasopore. This is a
synthetic material approved by FDA for use as a stent in postoperative sinus surgery
patients. This study will compare the Nasopore stent to other approved stenting materials.
Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients [Not yet recruiting]
This study will investigate how the use of Tranexamic acid and Bacitracin applied to the
bleeding site after the hemodialysis fistula needle is removed will affect skin wound