AZELEX SUMMARY
Allergan
AZELEX®
(azelaic acid cream) 20%
AZELEX® (azelaic acid cream) 20% contains azelaic acid, a naturally occurring saturated dicarboxylic acid.
AZELEX® Cream is indicated for the topical treatment of mild-to-moderate inflammatory acne vulgaris.
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NEWS HIGHLIGHTSMedia Articles Related to Azelex (Azelaic Acid Topical)
Health Tip: What's Triggering My Acne?
Source: MedicineNet Acne Specialty [2009.06.24]
Title: Health Tip: What's Triggering My Acne?
Category: Health News
Created: 6/24/2009 7:00:00 AM
Last Editorial Review: 6/24/2009
New Laser Combo Therapy Zaps Acne
Source: MedicineNet Acne Specialty [2009.03.09]
Title: New Laser Combo Therapy Zaps Acne
Category: Health News
Created: 3/7/2009 2:00:00 AM
Last Editorial Review: 3/9/2009
Acne Cream Not Linked to Raised Death Risk
Source: MedicineNet tretinoin Specialty [2009.01.26]
Title: Acne Cream Not Linked to Raised Death Risk
Category: Health News
Created: 1/24/2009 2:00:00 AM
Last Editorial Review: 1/26/2009
FDA OKs New Acne Gel Epiduo
Source: MedicineNet adapalene Specialty [2009.01.07]
Title: FDA OKs New Acne Gel Epiduo
Category: Health News
Created: 1/7/2009
Last Editorial Review: 1/7/2009
Acne (Pimples)
Source: MedicineNet Boils Specialty [2008.07.16]
Title: Acne (Pimples)
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 7/16/2008
Published Studies Related to Azelex (Azelaic Acid Topical)
A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy. [2009.07]
This two-phase, multicenter study was undertaken to examine the safety and efficacy of combination therapy with oral doxycycline and topical azelaic acid (AzA) 15% gel in moderate-to-severe papulopustular rosacea and to determine the effect of subsequent maintenance monotherapy with AzA 15% gel alone...
Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea. [2008.06]
BACKGROUND: Twice-daily azelaic acid (AzA) is the conventional regimen for papulopustular rosacea, but once-daily AzA may be equally effective, with greater convenience and dosing flexibility. In order to test this hypothesis, an exploratory study was conducted... CONCLUSION: Based on these findings and those of prior studies, once-daily AzA 15% gel can therefore be utilized as a safe, effective, and economical dosing option for the treatment of mild-to-moderate papulopustular rosacea. Once-daily dosing of AzA 15% gel was well accepted by patients and can offer considerable dosing flexibility and convenience for the patient as well as for the dermatologist.
Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15%. [2007.04]
Topical therapy for rosacea aims to reduce inflammatory lesions and decrease erythema but can carry side effects such as stinging, pruritus, and burning... Metronidazole gel 1% had a similar profile to white petrolatum.
Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. [2006.08]
CONCLUSIONS: Azelaic acid in 20% cream and 15% gel formulations appears to be effective in the treatment of papulopustular rosacea, particularly in regard to decreases in mean inflammatory lesion count and erythema severity. Compared with metronidazole, azelaic acid appears to be an equally effective, if not better, treatment option.
Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. [2006.04]
Rosacea is an inflammatory dermatologic disorder characterized by the presence of facial erythema, visible blood vessels, papules, and pustules... On average, the efficacy (including reduction in erythema) of the once-daily application of metronidazole 1% gel and twice-daily applications of azelaic acid 15% gel were similar.
Clinical Trials Related to Azelex (Azelaic Acid Topical)
Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma [Recruiting]
The purpose of this prospective, randomized, controlled, single-blinded investigation is to
study the efficacy, tolerability and safety of azelaic acid iontophoresis (AAI) versus
topical treatment with azelaic acid cream in female patients with melasma.
Azelaic Acid Versus Hydroquinone in Melasma [Recruiting]
Exploratory Study of Azelaic Acid 15% Foam Compared to Vehicle in Patients With Papulopustular Rosacea [Active, not recruiting]
This exploratory study is being performed to determine whether a new form formulation of
azelaic acid 15% is effective in the treatment of papulopustular rosecea.
A Study of Azelaic Acid (AzA) 15% in Topical Treatment of Mild to Moderate Perioral Dermatitis [Completed]
A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied Twice Daily Versus Once Daily [Completed]
To assess the efficacy and tolerability of azelaic acid 15% gel applied once daily versus
twice daily in the treatment of patients with papulopustular rosacea.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Azelex has an overall score of 5.50. The effectiveness score is 5 and the side effect score is 5. The scores are on ten point scale: 10 - best, 1 - worst.
| | Azelex review by 62 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | twice daily application to skin (dosage frequency: twice daily) for the period of 2 years |
| Other conditions: | | HTN |
| Other drugs taken: | | Hydrochlorothiazide | | |
Reported Results |
| Benefits: | | Significant reduction in acne lesions. The size, frequency and severity of the lesions was reduced in the first week of use. |
| Side effects: | | Drying, flaking, peeling of the skin where the cream was applied. These side effects were reduced by using the product only at night time. |
| Comments: | | I noticed reduction in frequency and severity of acne lesions during the first week of use. Application was done on clean dry skin and a non-oily moisturizer was applied after the product had absorbed. Sunscreen was applied for daytime use. |
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| | Azelex review by 44 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne |
| Dosage & duration: | | 20% Cream (dosage frequency: once daily) for the period of 2 weeks |
| Other conditions: | | hyperpigmentation |
| Other drugs taken: | | Synthroid and Cytomel | | |
Reported Results |
| Benefits: | | I was not able to use the cream long enough because of the side effects. |
| Side effects: | | The cream itched and burned severely to the point of being nearly intolerable for the first week. The burning subsided in the second week, but not to the point of being usable on a daily basis. |
| Comments: | | Application of cream nightly 15 minutes after washing. Product information advised waiting, but it still burned and itched when applying it after waiting. it had no real visible effect during the time I used it. I gave it a 2 instead of 1 because I felt a very subjective glimmer of potential improvement at the end of the period, but not enough to overcome the pain. |
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Page last updated: 2009-10-20
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