AXSAIN SUMMARY
Axsain contains capsaicin USP, in a patented emollient base containing benzyl alcohol, cetyl alcohol, glyceryl stearate, isopropyl myristate, lidocaine hydrochloride, PEG-100 stearate, purified water; sorbitol solution and white petrolatum.
Axsain is indicated for the temporary relief of neuralgia pain,
including painful diabetic neuropathy (PDN) and postherpetic neuralgia (PHN), when used under the supervision of a physician. Axsain is particularly useful as adjunctive therapy for PDN and PHN patients experiencing incomplete pain relief despite taking oral antiepileptics or tricyclic antidepressants.
|
NEWS HIGHLIGHTS
Published Studies Related to Axsain (Capsaicin / Lidocaine)
The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study. [2009.07]
Adults over 65 years exhibit a prolonged punctate hyperalgesia induced by topical application of capsaicin. The aim of this study was to investigate the role of peripheral afferent input in the slowed resolution of punctate hyperalgesia in older people... The relationship between such age-related changes and the chronicity of pain in older adults should be further explored.
Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. [2009.06]
BACKGROUND & AIMS: Bioactive ingredients have been shown to reduce appetite and energy intake. The magnitude of these effects might depend on energy balance why it was investigated how capsaicin, green tea, CH-19 sweet pepper as well as green tea and capsaicin affect appetite and energy intake during respectively negative and positive energy balance... CONCLUSIONS: Bioactive ingredients had energy intake reducing effects when used in combinations and in positive energy balance. Energy balance did not affect possible treatment induced energy intake, but did affect appetite by supporting negative energy balance. Bioactive ingredients may therefore be helpful in reducing energy intake and might support weight loss periods by relatively sustaining satiety and suppressing hunger.
The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. [2009.06]
BACKGROUND: Addition of capsaicin to the diet has been shown to increase satiety and thermogenesis. The effects of capsaicin on ghrelin, peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), in relation to changes in hunger and satiety are unknown. AIM: To test the acute effects of a lunch containing capsaicin on gut derived hormones (GLP-1, ghrelin, and PYY), energy expenditure (EE), substrate oxidation and satiety at lunch in the postprandial state... CONCLUSIONS: An acute lunch containing capsaicin had no effect on satiety, EE, and PYY, but increased GLP-1 and tended to decrease ghrelin.
Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. [2009.01]
CONCLUSION: In conclusion, the present study found that 5 grams of capsicum presented capsaicin levels that were associated with a decrease in plasma glucose levels and the maintenance of insulin levels. The present result might have clinical implications in the management of type 2 diabetes.
Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin. [2009.01]
The present human study aimed at investigating the effect of subcutaneous administration of Botulinum toxin type A (BoNT/A) on capsaicin-induced trigeminal pain, neurogenic inflammation and experimentally induced cutaneous pain modalities. Fourteen healthy males (26.3+/-2.6 years) were included in this double-blind and placebo-controlled trial...
Clinical Trials Related to Axsain (Capsaicin / Lidocaine)
Sensory Function After Wound Instillation of Capsaicin [Completed]
The use of capsaicin as a potential analgesic drug for postoperative pain relies on the
ability of capsaicin to induce membrane lysis of c-nerve fibers. In a previous randomized
placebo controled blinded study of this effect we found a significant effect of capsaicin
versus placebo. Before surgery all patients were examined by quantitative sensory testing to
evaluate sensory function. In this study an identical sensory testing will examine if
changes to the sensory function in capsaicin treated patients is identical to placebo treated
patients. No new intervention will be performed
Effects of Capsaicin on the Structure, Distribution, and Function of Cutaneous Small Nerve Fibers in Psoriatic Skin [Active, not recruiting]
The purpose of this research study is to examine the role of nerves in the skin in psoriasis
and to better understand the effects of capsaicin in psoriasis. In this study, capsaicin will
be compared to a moisturizer (aquaphor ointment).
Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects [Recruiting]
The purpose of this research is to study how people respond differently to capsaicin in
different racial groups and the effect it has on your pain levels. Capsaicin is a natural
product made from hot chili peppers that is useful for treating the itch symptoms of skin
disease.
Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy [Active, not recruiting]
The purpose of the study is to gain initial information on the tolerability and feasibility
of high-concentration capsaicin patches for the treatment of painful HIV-associated
neuropathy, whether resulting from HIV disease and/or antiretroviral drug exposure. The
study will also provide preliminary safety and efficacy information.
Study of Three Capsaicin Dermal Liquid Formulations on Epidermal Nerve Fiber Immunostaining and Sensory Function [Completed]
The purpose of this study is to evaluate potential changes in epidermal nerve fiber
immunostaining (ENFI) and sensory nerve function in healthy normal volunteers following
single applications of three different investigational topical Capsaicin Dermal Liquids (10%
w/v trans capsaicin), and a comparable control (propylene glycol). In addition, the pain and
tolerability of the application of each formulation will also be assessed. Data from this
clinical study may be used to select a formulation for further clinical evaluation.
|
