CONTRAINDICATIONS
Ischemic or Vasospastic Coronary Artery Disease, or Other Significant Underlying Cardiovascular Disease
Do not use AXERT® (almotriptan malate) in patients with ischemic heart disease (angina pectoris, history of myocardial infarction, or documented silent ischemia), or in patients who have symptoms or findings consistent with ischemic heart disease, coronary artery vasospasm, including Prinzmetal's variant angina, or other significant underlying cardiovascular disease [see Warnings and Precautions].
Cerebrovascular Syndromes
Do not use AXERT® in patients with cerebrovascular syndromes including (but not limited to) stroke of any type as well as transient ischemic attacks [see Warnings and Precautions].
Peripheral Vascular Disease
Do not use AXERT® in patients with peripheral vascular disease including (but not limited to) ischemic bowel disease [see Warnings and Precautions].
Uncontrolled Hypertension
Because AXERT® may increase blood pressure, do not use AXERT® in patients with uncontrolled hypertension [see Warnings and Precautions].
Ergotamine-Containing and Ergot-Type Medications
Do not use AXERT® and ergotamine-containing or ergot-derived medications like dihydroergotamine, ergotamine tartrate, or methysergide within 24 hours of each other [see Drug Interactions].
Concomitant Use With 5-HT Agonists (e.g., Triptans)
AXERT® and other 5-HT1 agonists (e.g., triptans) should not be administered within 24 hours of each other [see Warnings and Precautions and ].
Hemiplegic or Basilar Migraine
Do not use AXERT® in patients with hemiplegic or basilar migraine.
Hypersensitivity
AXERT® is contraindicated in patients with known hypersensitivity to almotriptan or any of its inactive ingredients.
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