Avita (Tretinoin) - Summary

AVITA SUMMARY

AVITA^® Cream, a topical retinoid, contains tretinoin 0.025% by weight in a hydrophilic cream vehicle of stearic acid, polyolprepolymer-2, isopropyl myristate, polyoxyl 40 stearate, propylene glycol, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water.

AVITA^® Cream is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of this product in the treatment of other disorders have not been established.

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NEWS HIGHLIGHTS

Published Studies Related to Avita (Tretinoin)

Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. [2014]
CONCLUSION: The combination TR/AVG was well tolerated and significantly more

Tretinoin cyclodextrin complex (RA/CyD) causes less irritation with an equal antiwrinkle effect compared with conventional tretinoin: clinical and histologic studies of photoaged skin. [2012]
the side effects compared with RA treatment alone... CONCLUSION: The findings show that RA and RA/CyD result in the equivalent

A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. [2012]
rosacea after 12 weeks of usage... CONCLUSIONS: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025%

A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. [2012]
Vitamin A and its derivatives (commonly termed retinoids) are widely used in topical anti-aging products. Certain retinoids such as retinol and its esters are available without a prescription, while others such as tretinoin are available only via prescription... Subjects reported >93 percent overall satisfaction with both products at weeks 8 and 12.

Further enhancement of facial appearance with a hydroquinone skin care system plus tretinoin in patients previously treated with botulinum toxin Type A. [2011.07]
BACKGROUND: A hydroquinone (HQ) skin care system has been designed for use in conjunction with nonsurgical procedures. OBJECTIVE: The authors evaluate the efficacy of this system plus tretinoin for improving facial appearance in comparison to a standard skin care regimen in users of botulinum toxin Type A (BoNT-A)... CONCLUSIONS: Adjunctive use of the HQ system plus tretinoin can further enhance the improvements in facial appearance attained with BoNT-A. Applying the HQ system plus tretinoin offers multiple clinical benefits over standard skin care, including significantly greater improvements in fine lines/wrinkles and hyperpigmentation.

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Clinical Trials Related to Avita (Tretinoin)

90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) [Active, not recruiting]
This study is for patients with neuroblastoma or a neuroendocrine tumor who have not been able to have standard therapy or have failed the first-line therapy. The purpose of this study is to assess the safety and effectiveness of the combination of retinoic acid and Onalta (Y-90-DOTA-tyr3-Octreotide) in treating neuroblastoma and neuroendocrine tumors.

Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles [Completed]
The purpose of this study is to assess the comparative efficacy of retinol 1. 0% and tretinoin 0. 02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris [Active, not recruiting]
The purpose of this study is to evaluate whether Cerave lotion followed by Acanya Gel in the morning in combination with Cerave lotion followed by Atralin gel in the evening is safe and effective for the treatment of acne vulgaris.

Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Recruiting]
This phase I trial studies the side effects and best dose of tretinoin when given together with lithium carbonate in treating patients with relapsed or refractory acute myeloid leukemia. Lithium carbonate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Tretinoin may help [type of cancer] cells become more like normal cells, and to grow and spread more slowly. Giving lithium carbonate together with tretinoin may kill more cancer cells

Atralin Gel for the Treatment of Rosacea [Terminated]
Erythematotelangiectatic rosacea is a type of rosacea that causes a red face often with frequent flushing, topical sensitivity and prominent blood vessels. We think that long term damage to skin from the sun (photodamage) may play a role in causing this type of rosacea. Tretinoin is a topical medication that is known to improve photodamage. We want to find out if Atralin (tretinoin 0. 05%) Gel used for up to 46 weeks will improve erythematotelangiectatic rosacea (ETR).

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PATIENT REVIEWS / RATINGS / COMMENTS

Avita review by 46 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		HYPER PIGMENTATION, WRINKLES
Dosage & duration:		0.5% (dosage frequency: nightly) for the period of 2 months - ongoing
Other conditions:		asthma
Other drugs taken:		salbutamol
		Reported Results
Benefits:		After only three days of treatment my partner noticed a reduction in the hyperpigmentation, it took me about a month to notice these effects. Having used tretinoin now for two months the crepiness under my eyes is greatly reduced, there is undoubtedly a marked improvement in the texture of my skin and the hyperpigmentation is getting better every day.
Side effects:		Side effects were minor skin irritation especially in naso labial folds(itching, flaking and redness) and under eye area (slightly swollen on waking), however these symptoms were short lived and in the space of ten days disappeared altogether. There were a couple of occasions where i noticed small dry patches of skin which vanished in a couple of days.
Comments:		very simple really, wash and dry face at night, wait thirty minutes for face to dry completley, apply a pea sized amount of tretinoin avoiding corners of nose and eye lids.

Avita review by 23 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Acne
Dosage & duration:		.025% (dosage frequency: every night) for the period of 6 months
Other conditions:		sensitive skin
Other drugs taken:		none
		Reported Results
Benefits:		There was decrease in my acne and my skin became considerably smoother.
Side effects:		Luckily I did not notice many side effects. I only experienced occasional flaky skin and a very slight stinging sensation.
Comments:		I used Tretinoin every night after cleansing my face. After cleansing, I waited 15-20 minutes (as my doctor had recommended) and applied about a dime size of the medication on my entire face. I made sure to use a sunscreen in the morning because Tretinoin makes the skin sensitive to sunlight.

Avita review by 42 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		anti ageing
Dosage & duration:		daily (dosage frequency: twice a week) for the period of one month
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		Didn't really see any improvements but not sure if I am applying correct amount.
Side effects:		Some dry skin and flaking, which made make-up application difficult. Tried to exfoliate to which gave some improvement. Also, skin sensitivity after the initial peel of skin. Not sure if I will continue to use this product as I cannot see any improvement to fine lines.
Comments:		Daily application caused some irritation, so started to use is twice as week. Not sure if this is why I have seen little improvement.