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AVC Cream (Sulfanilamide Vaginal) - Summary



AVC® CREAM is a preparation for vaginal administration for the treatment of Candida albicans infections and contains sulfanilamide, an anti-infective agent.

AVC CREAM (SULFANILAMIDE) is indicated for the following:

For the treatment of vulvovaginitis caused by Candida albicans. (See CLINICAL PHARMACOLOGY.)

See all AVC Cream indications & dosage >>


Published Studies Related to AVC Cream (Sulfanilamide Vaginal)

Multicenter comparison of clotrimazole vaginal tablets, oral metronidazole, and vaginal suppositories containing sulfanilamide, aminacrine hydrochloride, and allantoin in the treatment of symptomatic trichomoniasis. [1997.03]
BACKGROUND AND OBJECTIVES: Trichomonas vaginalis is a common vaginal pathogen. Oral metronidazole is the drug of choice for the treatment of trichomoniasis. Oral metronidazole, however, may cause unpleasant side effects and is contraindicated during the first trimester of pregnancy. In vitro studies and preliminary clinical data have suggested that intravaginal clotrimazole may be effective against this pathogen. GOALS: To compare the efficacy of clotrimazole vaginal tablets, oral metronidazole, and vaginal suppositories containing sulfanilamide, aminacrine, and allantoin (AVC suppositories) in the treatment of women with symptomatic trichomoniasis... CONCLUSIONS: Oral metronidazole was more effective in eradicating T. vaginalis than clotrimazole vaginal tablets or AVC vaginal suppositories. All three regimens reduced symptoms; oral metronidazole was more effective in reducing symptoms than either topical preparation.

Methemoglobinemia induced by topical vaginal sulfanilamide cream in a patient with cervical cancer: a case report. [2005.06]
CONCLUSION: Although methemoglobinemia associated with topical anesthetics has been well documented, to our knowledge this is the first reported case of methemoglobinemia induced by exposure to topical sulfanilamide cream. Although patients undergoing intracavitary radiation treatment for cervical cancer are at risk for cyanosis due to the development of deep vein thromboses and pulmonary embolism, methemoglobinemia should be suspected in the setting of acute cyanosis with a normal arterial oxygen pressure.

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Page last updated: 2006-01-31

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