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Augmentin XR (Amoxicillin / Clavulanate Potassium) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

AUGMENTIN XR drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Following overdosage, patients have experienced primarily gastrointestinal symptoms including stomach and abdominal pain, vomiting, and diarrhea. Rash, hyperactivity, or drowsiness have also been observed in a small number of patients.

In the case of overdosage, discontinue AUGMENTIN XR, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison control center suggested that overdosages of less than 250 mg/kg of amoxicillin are not associated with significant clinical symptoms and do not require gastric emptying.5

Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with amoxicillin.

Crystalluria, in some cases leading to renal failure, has also been reported after amoxicillin overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of amoxicillin crystalluria.

Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of both amoxicillin and clavulanate. Both amoxicillin and clavulanate are removed from the circulation by hemodialysis (see DOSAGE AND ADMINISTRATION).

CONTRAINDICATIONS

AUGMENTIN XR is contraindicated in patients with a history of allergic reactions to any penicillin. It is also contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with treatment with amoxicillin/clavulanate potassium.

AUGMENTIN XR is contraindicated in patients with severe renal impairment (creatinine clearance < 30 mL/min.) and in hemodialysis patients.

REFERENCES

  1. Clinical and Laboratory Standards Institute (CLSI) (formerly the National Committee for Clinical Laboratory Standards). Performance Standards for Antimicrobial Susceptibility Testing − Twentieth Informational Supplement. CSLI Document M100-S20, Vol. 30, No. 1. CLSI, Wayne, PA, 2010.
  2. Clinical and Laboratory Standards Institute (CLSI) (formerly the National Committee for Clinical Laboratory Standards). Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria − Seventh Edition. Approved Standard CSLI Document M11-A7, Vol. 27, No. 2. CLSI, Wayne, PA, 2007.
  3. Clinical and Laboratory Standards Institute (CLSI) (formerly the National Committee for Clinical Laboratory Standards). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically − Eighth Edition. Approved Standard CLSI Document M7-A8, Vol. 29, No. 2. CLSI, Wayne, PA, 2009.
  4. Clinical and Laboratory Standards Institute (CLSI) (formerly the National Committee for Clinical Laboratory Standards). Performance Standards for Antimicrobial Disk Susceptibility Tests − Tenth Edition. Approved Standard CLSI Document M2-A10, Vol. 29, No. 1. CLSI, Wayne, PA, 2009.
  5. Swanson-Biearman B, Dean BS, Lopez G, Krenzelok EP. The effects of penicillin and cephalosporin ingestions in children less than six years of age. Vet Hum Toxicol 1988; 30: 66-67.




AUGMENTIN XR and AUGMENTIN are registered trademarks of GlaxoSmithKline.

MAALOX is a registered trademark of Novartis Consumer Health, Inc.

GlaxoSmithKline

Research Triangle Park, NC 27709

©2010, GlaxoSmithKline. All rights reserved.

September 2010                    AUX:11PI



Relabeling and Repackaging by:
Physicians Total Care, Inc.
Tulsa, OK        74146

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