NEWS HIGHLIGHTS
Published Studies Related to Atrovent HFA (Ipratropium Cation Inhalation)
Ipratropium bromide HFA. [2005]
Ipratropium bromide is a nonselective antagonist of the muscarinic receptors located on airway smooth muscle, and is delivered via a metered-dose inhaler (MDI). Because of the requirement to phase out chlorofluorocarbon (CFC)-propelled MDIs, the ipratropium bromide inhalation aerosol MDI has been redesigned with a hydrofluoroalkane as the propellant (ipratropium bromide HFA)...
Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. [2010.02.01]
Ipratropium bromide, an anticholinergic drug used for the treatment of asthma and chronic obstructive pulmonary disease, has low oral bioavailability, but systemic exposure, superior to oral administration, can be achieved by inhalation. Therefore, we investigated the pulmonary absorption mechanism of ipratropium using human bronchial epithelial BEAS-2B cells...
Clinical Trials Related to Atrovent HFA (Ipratropium Cation Inhalation)
Effectiveness of Ipratropium Bromide in Preventing Exercise-induced Bronchoconstriction in Athletes [Not yet recruiting]
Exercise-induced asthma (EIA) is common and often unrecognized among endurance athletes.
The mechanisms of asthma appear to be different between athletes and non-athletes, in that
the occurrence of asthma is higher among endurance athletes and seems to be promoted by
training. This suggests that factors inherent to athleticism, such as the parasympathetic
nervous system, which has been shown to change with endurance training and is known to lead
to narrowing of the airways, may be involved with the development of asthma in athletes.
Although asthma mechanisms and treatments have been extensively studied in classic
asthmatics, there is very limited data in athletes.
This will be a double-blind placebo-controlled study in which we plan to study 40
competitive endurance athletes. We will conduct an exercise test to evaluate maximal oxygen
uptake and 2 exercise challenge tests to provoke EIA. Prior to the exercise challenge tests
the athletes will randomly receive inhaled placebo or inhaled ipratropium bromide. We will
compare the athletes' airway response to the exercise challenge with and without the active
drug. We will also obtain a blood sample from all athletes to test for allergies and
evaluate whether our results are affected by atopic predisposition.
If ipratropium bromide proves to prevent EIA in athletes, this drug may be more appropriate
and effective than the currently used beta-2 agonists to target EIA in this population. The
results of this study may lead to improved clinical management of athletes with asthma.
A Study to Look at Day to Day Changes in Lung Function in COPD Subjects Taking Albuterol/Salbutamol and Ipratropium [Recruiting]
The objective of this study is to assess the daily variation in bronchodilator response to
an inhaled short acting beta2-agonist (albuterol/salbutamol) and an inhaled short acting
anticholinergic (ipratropium) individually and when used in combination in subjects with
COPD.
Acute Bronchodilator Response of a Single Dose of Atrovent or Berotec on Top of Pharmacodynamic Steady State of Spiriva [Completed]
To evalute acute effect of single dose of ipratropium (Atrovent) or fenoterol (Berotec) in
comparison to placebo when given to COPD patients on pharmacodynamic steady state of
tiotropium (Spiriva)
Effect of Ipratropium on Acute Bronchitis in Subjects Without Underlying Lung Disease [Completed]
ABSTRACT CONTEXT: Inappropriate antibiotic prescriptions for acute bronchitis is a major
public health concern because of antibiotic resistance. Effective therapies for managing the
symptoms of acute bronchitis are lacking, however.
OBJECTIVE: Determine if patients with acute bronchitis have better symptom control when
treated with inhaled ipratropium.
DESIGN, SETTING, PARTICIPANTS: COUGH STOP was a randomized, double blind, placebo controlled
trial comparing ipratropium with placebo in acute bronchitis. Subjects were referred by
their primary care provider or from urgent care clinics at a single institution. Subjects
had been diagnosed with acute bronchitis and had no significant co-morbidities.
INTERVENTION: Subjects received ipratropium or placebo inhalers, administering 2 puffs four
times daily. A structured telephone interview took place 2, 4, and 8 days after enrollment.
Medical records were reviewed at 60 days.
OUTCOME: The primary endpoint was improvement in cough symptomology; secondary endpoints
included subsequent antibiotic prescriptions and “well being. ” RESULTS: The ipratropium arm
improved significantly (better: 57. 6% day-2, 68. 3% day-4, 91. 9% day-8; c2 (1) = 21. 24, p <
.01) across the 8 days of the telephone survey. This score improved over the same time
period in the placebo arm, however the change was smaller and the difference was not
significant (better: 64. 8% day-2, 74. 6% day-4, 79. 7% day-8; c2 (1) = 4. 69, p =.321). More
than twice as many subjects in the placebo arm received subsequent antibiotic prescriptions
compared to the ipratropium arm (12 vs. 5 respectively), this trend did not meet the
threshold of significance (c2 (1) = 2. 84, p =.076).
CONCLUSION: Patients with acute bronchitis who are otherwise healthy have a more rapid
improvement in their cough symptom score when they are treated with ipratropium, and may be
at decreased risk of unnecessary antibiotic exposure.
Tiotropium Inhalation Capsules and Atrovent MDI Comparison Trial in Taiwan [Completed]
The objective of this study is to compare the bronchodilator efficacy and safety of
tiotropium inhalation capsules (18 mcg once daily) and Atrovent MDI (2 puffs of 20 mcg
q. i.d.) in patients with chronic obstructive pulmonary disease (COPD)
Reports of Suspected Atrovent HFA (Ipratropium Cation Inhalation) Side Effects
Death (3),
Dizziness (3),
Dyspnoea (3),
Dysgeusia (3),
Fear (2),
Oropharyngeal Pain (2),
Oral Discomfort (2),
Drug Effect Decreased (2),
Tremor (2),
Oral Pain (2), more >>
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