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Atropine (Atropine Sulfate) - Side Effects and Adverse Reactions


Adverse Reactions

Toxic effects from overdosage of atropine are not uncommon, especially in children. Individual tolerance varies greatly, but these systemic doses are likely to produce the following effects.

0.5 mg                   • Slight dryness of nose and mouth; bradycardia.
1 mg                      • Greater dryness of nose and mouth, with thirst; slowing then acceleration of heart; slight mydriasis.
2 mg                      • Very dry mouth; tachycardia with palpitation, mydriasis, slight blurring of near vision; flushed, dry skin.
5 mg                      • Increase in above symptoms plus disturbance of speech; difficulty in swallowing; headache, hot, dry skin; restlessness, with asthenia.
10 mg and over       • Above symptoms to extreme degree, plus ataxia, excitement, disorientation, hallucinations, delirium, and coma.
65 mg                    • May be fatal.

A scarlatiniform rash may occur. Atropine may produce fever, particularly in children, through inhibition of heat loss by evaporation. Although large doses of atropine may cause an alarming
condition, recovery is usual. In the treatment of atropine poisoning, respiratory assistance and symptomatic support are indicated. Pilocarpine is sometimes given but is of limited value.


Below is a sample of reports where side effects / adverse reactions may be related to Atropine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Atropine side effects / adverse reactions in 63 year old male

Reported by a physician from France on 2011-10-03

Patient: 63 year old male

Reactions: Shock

Adverse event resulted in: life threatening event

Suspect drug(s):
    Start date: 2011-08-19
    End date: 2011-08-19

    Start date: 2011-08-19
    End date: 2011-08-19

    Start date: 2011-08-19
    End date: 2011-08-19

    Start date: 2011-08-19
    End date: 2011-08-19

Possible Atropine side effects / adverse reactions in 80 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-17

Patient: 80 year old female weighing 55.0 kg (121.0 pounds)

Reactions: Torsade DE Pointes, Ventricular Arrhythmia

Suspect drug(s):
    Indication: Maintenance of Anaesthesia

Rocuronium Bromide
    Indication: Induction of Anaesthesia

    Dosage: 0.5 mug/sup-1/min/sup-1/
    Indication: Induction and Maintenance of Anaesthesia

    Indication: Product Used FOR Unknown Indication

    Indication: Induction of Anaesthesia

Other drugs received by patient: Oxygen

Possible Atropine side effects / adverse reactions in 59 year old male

Reported by a pharmacist from United States on 2011-10-19

Patient: 59 year old male weighing 64.4 kg (141.7 pounds)

Reactions: Hallucination, Delirium, Delusion

Adverse event resulted in: hospitalization

Suspect drug(s):
    Dosage: 2 drops tid sublingual
    Indication: Salivary Hypersecretion
    Start date: 2011-07-14

Carbidopa and Levodopa
    Dosage: 1 tab other po
    Administration route: Oral
    Indication: Parkinson's Disease
    Start date: 2003-05-23
    End date: 2011-07-19

See index of all Atropine side effect reports >>

Drug label data at the top of this Page last updated: 2014-07-15

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