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Atropine (Atropine Sulfate) - Side Effects and Adverse Reactions



Most of the side effects of atropine are directly related to its antimuscarinic action. Dryness of the mouth, blurred vision, photophobia and tachycardia commonly occur with chronic administration of therapeutic doses. Anhidrosis also may occur and produce heat intolerance or impair temperature regulation in persons living in a hot environment. Constipation and difficulty in micturition may occur in elderly patients. Occasional hypersensitivity reactions have been observed, especially skin rashes which in some instances progressed to exfoliation.

Adverse effects following single or repeated injections of atropine are most often the result of excessive dosage. These include palpitation, dilated pupils, difficulty in swallowing, hot dry skin, thirst, dizziness, restlessness, tremor, fatigue and ataxia. Toxic doses lead to marked palpitation, restlessness and excitement, hallucinations, delirium and coma. Depression and circulatory collapse occur only with severe intoxication. In such cases, blood pressure declines and death due to respiratory failure may ensue following paralysis and coma.


Below is a sample of reports where side effects / adverse reactions may be related to Atropine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Atropine side effects / adverse reactions in 63 year old male

Reported by a physician from France on 2011-10-03

Patient: 63 year old male

Reactions: Shock

Adverse event resulted in: life threatening event

Suspect drug(s):
    Start date: 2011-08-19
    End date: 2011-08-19

    Start date: 2011-08-19
    End date: 2011-08-19

    Start date: 2011-08-19
    End date: 2011-08-19

    Start date: 2011-08-19
    End date: 2011-08-19

Possible Atropine side effects / adverse reactions in 80 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-17

Patient: 80 year old female weighing 55.0 kg (121.0 pounds)

Reactions: Torsade DE Pointes, Ventricular Arrhythmia

Suspect drug(s):
    Indication: Maintenance of Anaesthesia

Rocuronium Bromide
    Indication: Induction of Anaesthesia

    Dosage: 0.5 mug/sup-1/min/sup-1/
    Indication: Induction and Maintenance of Anaesthesia

    Indication: Product Used FOR Unknown Indication

    Indication: Induction of Anaesthesia

Other drugs received by patient: Oxygen

Possible Atropine side effects / adverse reactions in 59 year old male

Reported by a pharmacist from United States on 2011-10-19

Patient: 59 year old male weighing 64.4 kg (141.7 pounds)

Reactions: Hallucination, Delirium, Delusion

Adverse event resulted in: hospitalization

Suspect drug(s):
    Dosage: 2 drops tid sublingual
    Indication: Salivary Hypersecretion
    Start date: 2011-07-14

Carbidopa and Levodopa
    Dosage: 1 tab other po
    Administration route: Oral
    Indication: Parkinson's Disease
    Start date: 2003-05-23
    End date: 2011-07-19

See index of all Atropine side effect reports >>

Drug label data at the top of this Page last updated: 2006-09-08

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