FOR USE IN NERVE AGENT AND INSECTICIDE POISONING ONLY
CAUTION! PRIMARY PROTECTION AGAINST EXPOSURE TO CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING IS THE WEARING OF PROTECTIVE GARMENTS INCLUDING MASKS DESIGNED SPECIFICALLY FOR THIS USE.
INDIVIDUALS SHOULD NOT RELY SOLELY UPON ANTIDOTES SUCH AS ATROPINE AND PRALIDOXIME TO PROVIDE COMPLETE PROTECTION FROM CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING.
SEEK IMMEDIATE MEDICAL ATTENTION AFTER INJECTION WITH ATROPEN®.
A STERILE SOLUTION FOR INTRAMUSCULAR USE ONLY
Each prefilled auto-injector provides a dose of the antidote atropine in a self-contained unit, specially designed for self or caregiver administration. Four strengths of AtroPen® are available; they are AtroPen® 0.25 mg, AtroPen® 0.5 mg, AtroPen® 1 mg, and AtroPen® 2 mg.
The AtroPen® Auto-Injector is indicated for the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides. The AtroPen ® Auto-Injector should be used by persons who have had adequate training in the recognition and treatment of nerve agent or insecticide intoxication. Pralidoxime chloride may serve as an important adjunct to atropine therapy.
The AtroPen ® is intended as an initial treatment of the muscarinic symptoms of insecticide or nerve agent poisonings (generally breathing difficulties due to increased secretions); definitive medical care should be sought immediately. The AtroPen® Auto-Injector should be administered as soon as symptoms of organophosphorous or carbamate poisoning appear (usually tearing, excessive oral secretions, wheezing, muscle fasciculations, etc.). In moderate to severe poisoning, the administration of more than one AtroPen® may be required until atropinization is achieved (flushing, mydriasis, tachycardia, dryness of the mouth and nose). (See DOSAGE AND ADMINISTRATION) In severe poisonings, it may also be desirable to concurrently administer an anticonvulsant if seizure is suspected in the unconscious individual since the classic tonic-clonic jerking may not be apparent due to the effects of the poison. In poisonings due to organophosphorous nerve agents and insecticides it may also be helpful to concurrently administer a cholinesterase reactivator such as pralidoxime chloride.
Media Articles Related to Atropen Auto-Injector (Atropine)
Nearsightedness progression in children slowed down by medicated eye drops
Source: Eye Health / Blindness News From Medical News Today [2015.11.17]
Researchers present findings on five-year clinical trial of low-dose atropine for myopia at AAO 2015, the American Academy of Ophthalmology's annual meeting.
Published Studies Related to Atropen Auto-Injector (Atropine)
Risk factors for progressive myopia in the atropine therapy for myopia study. 
DESIGN: Retrospective cohort study... CONCLUSIONS: Doctors and parents need to be aware that there is a small group of
Atropine for the treatment of childhood myopia: changes after stopping atropine
0.01%, 0.1% and 0.5%. 
DESIGN: Prospective randomized double-masked clinical trial... CONCLUSION: There was a myopic rebound after atropine was stopped, and it was
Intrathecal atropine to prevent postoperative nausea and vomiting after Cesarean section: a randomized, controlled trial. [2011.08]
BACKGROUND: Postoperative nausea and vomiting (PONV) is a common adverse effect of intrathecal morphine, especially after Cesarean section. This randomized controlled trial investigated the effects of intrathecal administration of a small-dose of atropine on postoperative nausea and vomiting after Cesarean section... CONCLUSION: Intrathecal atropine had a significant antiemetic effect, making it a useful adjunct for intrathecal opioid-related PONV.
Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses. [2011.05]
REASONS FOR PERFORMING STUDY: Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia. HYPOTHESIS: Hyoscine would induce positive chronotropism of shorter duration than atropine, without adversely impairing intestinal motility in detomidine sedated horses... CONCLUSION: Hyoscine is a shorter acting positive chronotropic agent than atropine, but does not potentiate the impairment in intestinal motility induced by detomidine. Because of severe hypertension, routine use of anticholinergics combined with detomidine is not recommended. POTENTIAL RELEVANCE: Hyoscine may represent an alternative to atropine for treating bradycardia. (c) 2010 EVJ Ltd.
Addition of atropine to submaximal exercise stress testing in patients evaluated for suspected ischaemia with SPECT imaging: a randomized, placebo-controlled trial. [2011.02]
PURPOSE: To evaluate the effects of the addition of atropine to exercise testing in patients who failed to achieve their target heart rate (HR) during stress myocardial perfusion imaging with single-photon emission computed tomography (SPECT)... CONCLUSION: The addition of atropine at the end of exercise testing is more effective than placebo in raising HR to adequate levels, without additional risks of complications. The use of atropine in patients who initially failed to achieve their maximal predicted HR is associated with a higher probability of achieving a diagnostic myocardial perfusion study.
Clinical Trials Related to Atropen Auto-Injector (Atropine)
Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old [Completed]
This study is designed to evaluate the effectiveness of adding a plano lens to weekend
atropine after visual acuity has stabilized with weekend atropine but amblyopia is still
present. Children ages 3 to <8 years with visual acuity of 20/50 to 20/400 in the amblyopic
eye will be enrolled in a run-in phase with weekend atropine until no improvement, followed
by randomization of eligible patients to weekend atropine treatment with a plano lens over
the sound eye versus without a plano lens over the sound eye. The primary objective is to
determine if adding a plano lens to weekend atropine will improve visual acuity in patients
with amblyopia still present after visual acuity has stabilized with initial treatment.
Effectiveness of Atropine and Glycopyrrolate to Reduce Hyper Salivation With Ketamine Sedation [Completed]
The purpose of this study is to determine if the antisialagogues (anti-salivary agents),
Atropine and Glycopyrrolate, are effective in reducing hypersalivation when sedating
patients with Ketamine for procedural sedation in the emergency department or abscess
clinic. The investigators will measure salivary flow rate by collecting oral secretions by
oral suctioning over a 30 minute time period starting with the administration of Ketamine.
The investigators hypothesize that patients who receive either atropine or glycopyrrolate
will have fewer oral secretions than patients who receive placebo.
Heart Rate Response to Atropine Doses Less Than 0.1mg IV to Anesthetized Infants [Completed]
An infants heart rate is very important because it ensures that blood is pumped to all
organs in the body. Heart rate may decrease during anesthesia and surgery, and this is why
the anesthesiologist will often give a medication to prevent this from happening. The most
common drug for this purpose is called atropine. The dose of most drugs given to babies is
based upon the baby's weight, but some believe that the dose of atropine should not be less
than 0. 1mg. However there is no evidence to support this minimum dose. A larger dose of
atropine may cause a very fast heart rate instead. Anesthesiologists routinely dose the
atropine based upon the baby's weight without regard for a minimum dose.
The purpose of the present study is to measure the heart rate after doses of atropine in
neonates and infants who receive less than 0. 1 mg.
0.6 vs. 1.2 mg Atropine Together With Neostigmine 2.5 mg on Heart Rate in Patient Receiving Muscle Relaxant [Completed]
Balanced general anesthesia with neuromuscular blocking agents has been widely used for
surgery.. At the end of surgery, neostigmine has been given for the reversal of
neuromuscular blocking agents with several adverse effects such as bradycardia and profuse
secretion. Atropine has been used to prevent those side effects of neostigmine. The
routine dosages of the two drugs are 2. 5 mg of neostigmine and 1. 2 mg of atropine.
Tribuddharat S ey al. (1) has demonstrated that after giving 0. 9 mg atropine together with
2. 5 mg of neostigmine the mean heart rate during 1-8 minutes after the administration was
increase 2-26 beats/min (bpm). At 9 and 10 minutes after administration of the drugs, the
mean heart rate were decrease 0. 9 and 1. 6 bpm In the control group which receiving 1. 2 mg of
atropine, the mean heart rate during 1-10 minutes after administration was increase 4-32
bpm. However this study did not report the incidence of bradycardia and blood pressure. The
mean heart rate prior to atropine and neostigmine was 74. 43 + 11. 82 bpm.(1)
Salem MG et al. (2) has demonstrated that after receiving 1. 2 mg of atropine and 5 mg of
neostigmine the mean heart rate during 2-110 minutes was decrease 5-29 bpm with the lowest
heart rate at 40 minutes after administration. This study also did not report the blood
The baseline heart rate (HR) before administration of the reversal was associated with the
following heart rate. Heinonen J et al. (3) has demonstrated that 80% of the patients after
receiving 0. 015 mg/kg of atropine 3 minutes before 0. 03 mg of neostigmine for the reversal
of pancuronium experienced bradycardia (heart rate < 50 bpm) compared with none in patients
receiving alcuronium. However, before administration of atropine and neostigmine, the mean
heart rate of patients was significantly lower in the pancuronium group.
Either tachycardia or bradycardia with hypotension causes adverse affect to patient
especially in specific group like patient with coronary artery disease or undergoing
The primary objective of our study is to demonstrate the effect on heart rate (HR) and blood
pressure of 0. 6 mg atropine and 2. 5 mg neostigmine for the reversal of muscle relaxant
compare to 1. 2 mg atropine.
Atropine Versus no Atropine for Neonatal Rapid Sequence Intubation [Recruiting]
The purpose of this study is to compare heart rate in infants who receive atropine as a part
of their medication before intubation to those who do not.
To be able to find out , we need to divided babies into 2 groups;
group 1 : receives atropine + sedation + muscle relaxant group 2 : receives water or saline
( placebo group) + sedation + muscle relaxant
Then we need to compare heart rate during intubation and duration of intubation between the