ATRACURIUM SUMMARY
ATRACURIUM BESYLATE INJECTION USP
Atracurium Besylate Injection is an intermediate-duration, nondepolarizing, skeletal muscle relaxant for intravenous administration. Atracurium besylate is designated as 2,2’-[1,5-pentanediylbis[oxy (3-oxo-3,1-propanediyl)]]bis[1-[(3,4 dimethoxyphenyl)methyl]- 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate.
Atracurium Besylate Injection is indicated, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
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NEWS HIGHLIGHTSMedia Articles Related to Atracurium
Abdominal Surgery Without General Anesthesia
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
Need For Emergency Airway Surgery For Hard-to-Intubate Patients Reduced
Source: Respiratory / Asthma News From Medical News Today [2009.11.18]
Be prepared, that old Boy Scout motto, is being applied with great success to operating room patients whose anatomy may make it difficult for physicians to help them breathe during surgery, Johns Hopkins researchers report in a new study. When patients undergo general anesthesia, they stop breathing on their own and anesthesiologists must quickly insert a tube into the airway as a first step in machine-assisted breathing.
New Technique For Injectable Facial Fillers Improves Comfort, Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
Published Studies Related to Atracurium
Clinical predictors of duration of action of cisatracurium and rocuronium administered long-term. [2009.09]
BACKGROUND: The duration of action of neuromuscular blocking drugs (NBDs) varies between individuals and even within individuals in different settings. OBJECTIVES: To define predictors of variance in duration of action of rocuronium and cisatracurium administered long-term... CONCLUSION: Duration of NBD treatment is strongly predictive of the duration of action of rocuronium, and body temperature is predictive of the duration of action of cisatracurium. These data may help decrease the incidence of drug-induced muscle weakness in recovery rooms and surgical intensive care units, particularly if neuromuscular transmission monitoring is not available.
[Rocuronium vs atracurium vs suxamethonium for double-lumen endobronchial tube intubation] [2009.04]
BACKGROUND: Intubation with a double lumen tube requires excellent and stable relaxation, necessary for accurate positioning of the device using a fibre optic scope... DISCUSSION: Although all drugs given in equipotent doses proved to be suitable for the planned procedure, we conclude that suxamethonium could easily be abandoned in routine anaesthesia for elective lung surgery.
Effects of ephedrine on intubating conditions following priming with atracurium: a randomized clinical trial. [2009.03]
BACKGROUND: Priming is a well-known method to accelerate the onset of action of nondepolarizing neuromuscular-blocking agents. It consists of administration of a small dose of neuromuscular blocking agent several minutes before the principal dose is given. Ephedrine has been shown to improve the intubating conditions of rocuronium following its priming with a small dose. However, the potential effects of ephedrine on intubating conditions using atracurium after its priming with a small dose have not yet been studied. Since rocuronium is not available in Iran, atracurium is widely used as an alternative... CONCLUSION: The effects of ephedrine on improving intubating conditions following atracurium priming were not statistically significant. Given the risk of exacerbation of coronary ischemia by tachycardia, and the negative results on intubating conditions in our study, we cannot recommend the use of ephedrine for improving intubating conditions following priming with atracurium.
Comparative study of neuromuscular blocking and hemodynamic effects of rocuronium and cisatracurium under sevoflurane or total intravenous anesthesia. [2009.02]
CONCLUSION: We conclude that the effects of rocuronium and cisatracurium are significantly enhanced during sevoflurane compared with propofol anesthesia and the recovery is lower.
Priming with rocuronium to accelerate the onset time of cisatracurium during intubation. [2009.01]
Background: The priming technique, in which a small dose of nondepolarizing muscle relaxant is administered 3-6 minutes before giving the intubation dose, can speed up the onset of muscle relaxation in patients with paralysis during intubation... Priming with rocuronium for 3 minutes improved the onset time of cisatracurium even more than priming with cisatracurium itself.
Clinical Trials Related to Atracurium
The Comparability of Bispectral Index and Neurosense During Anesthesia [Recruiting]
The assessment of anesthesia depth was based, until recently, on the evolution of
hemodynamic parameters. Nowadays it can be evaluated by several monitoring methods, derived
from electroencephalogram analysis, namely the Bispectral Index (Aspect Medical Systems,
Newton, USA). A new modality is currently under development: the NeuroSENSE (Cleveland
Medical Devices Inc., Cleveland, OH 44103, USA). The goal of this study is to compare both
monitoring modalities during anesthesia.
I-Gel Versus Disposable Laryngeal Mask (LMA) for General Anesthesia (GA) With Controlled Ventilation [Recruiting]
Randomized controlled trial comparing performance of the I-gel and disposable Laryngeal Mask
Airways under controlled ventilation. 200 patients, 100 in each arm. Measurement of peak
airway and sealing pressures. Postoperative questionnaires at 1 and 24hrs.
Hypothesis
There is no difference between the performance* of the I-gel and disposable laryngeal mask
airways for controlled ventilation under general anesthesia.
*as defined by peak airway pressure and sealing pressures.
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