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Ativan (Lorazepam) - Summary

 
 



ATIVAN SUMMARY

ATIVAN (lorazepam) Injection
CIV
Rx only

Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2 H -1, 4-benzodiazepin-2-one.

Status Epilepticus

ATIVAN Injection is indicated for the treatment of status epilepticus.

Preanesthetic

ATIVAN Injection is indicated in adult patients for preanesthetic medication, producing sedation (sleepiness or drowsiness), relief of anxiety, and a decreased ability to recall events related to the day of surgery. It is most useful in those patients who are anxious about their surgical procedure and who would prefer to have diminished recall of the events of the day of surgery (see PRECAUTIONS, Information for Patients).


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NEWS HIGHLIGHTS

Published Studies Related to Ativan (Lorazepam)

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. [2014]
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus...

Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety. [2014]
vertigo reduction compared with lorazepam in ED patients... CONCLUSION: Our study demonstrated the evidence that promethazine is superior to

A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal. [2013]
withdrawal in a double blind design... CONCLUSION: Lorazepam is more effective than chlordiazepoxide in alcohol

RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. [2011.10]
Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting has been shown to be associated with improved outcomes. However, an increasing number of Emergency Medical System (EMS) protocols use an intramuscular (IM) route because it is faster and consistently achievable...

Lorazepam effects on Word Memory Test performance: a randomized, double-blind, placebo-controlled, crossover trial. [2011.07]
The Word Memory Test (WMT) is a common measure of symptom validity. To investigate the effects of acute benzodiazepines on WMT scores, oral lorazepam 2 mg (LOR) and placebo were administered 1 week apart in a randomized, double-blind, placebo-controlled, crossover study.

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Clinical Trials Related to Ativan (Lorazepam)

Fasting Study of Lorazepam Tablets 2 mg and Ativan Tablets 2 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's lorazepam 2 mg tablets to Wyeth's Ativan 2 mg tablets following a single, oral 2 mg (1 x 2 mg) dose administered under fasting conditions.

Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2) [Recruiting]
Children with seizures are frequently seen in the emergency department. The drug lorazepam, which is commonly used, is not labeled by the US Food and Drug Administration for children for this use. The FDA, under the Best Pharmaceuticals for Children Act, has requested that a study comparing diazepam, a drug that is labeled by the FDA for this indication, with lorazepam be performed. The study will show whether one drug is more effective and safe than the other.

Lorazepam Sedation for Critically Ill Children [Suspended]
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs. The purpose of this study is to make sure that lorazepam, when given to children who are very sick in the Intensive Care Unit and who are on a breathing machine, is safe and works as well as a drug called midazolam. Midazolam is already approved by the FDA for this use, but lorazepam is not, even though both drugs are commonly used for sedation.

Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Patients With Nausea [Recruiting]
This randomized clinical trial studies lorazepam, diphenhydramine hydrochloride, and haloperidol gel in patients with nausea. Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting.

Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers [Not yet recruiting]
RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting. PURPOSE: This clinical trial studies lorazepam, diphenhydramine hydrochloride, and haloperidol gel in healthy volunteers.

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Reports of Suspected Ativan (Lorazepam) Side Effects

Amnesia (30)Chronic Obstructive Pulmonary Disease (28)Emphysema (23)Bedridden (21)Muscle Spasms (16)Insomnia (13)Confusional State (12)Abdominal Pain (11)Drug Hypersensitivity (11)Feeling Abnormal (11)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 17 ratings/reviews, Ativan has an overall score of 6. The effectiveness score is 8.24 and the side effect score is 6.59. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Ativan review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Anxiety
Dosage & duration:   2mg taken as needed for the period of as needed
Other conditions:   N/A
Other drugs taken:   None
  
Reported Results
Benefits:   It really help me to cope with the anxiety
Side effects:   Make you tired.
Comments:   Had to take one when not feeling good. Or if anxiety issue to go to the doctor, take one, one hour prior apt

 

Ativan review by 30 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   anxiety
Dosage & duration:   1mg at night taken once a day for the period of one weeks
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   It helped relieve anxiety because it made me sleep. I found that prior to taking this medication, I could not sleep and that I was not eating properly. My overall health was suffering.
Side effects:   It made me so sleepy and sluggish that I could not function properly the next day. While it did resolve sleep issues, it led to many other issues.
Comments:   moderate anxiety.

 

Ativan review by 67 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Anxiety from a reaction
Dosage & duration:   .o5 3 x daily as needed (dosage frequency: 3 x daily) for the period of 10 months then I found out
Other conditions:   None docs looking for cancer... None!
Other drugs taken:   None
  
Reported Results
Benefits:   Became addictive .. Docs never told anything that it should only be used very short term, less then two weeks! The then become addictive. Not only that, the told me nothing of side affects, nor tolerance withdrawals, nor, you need to withdraw slowly. These are very dangerous drugs, you my think it helps, but you will pay he'll being on any benzodizapines. If you don,t believe this, go towww.benzo.org read dr (prof) ashton,s Manuel. You will suffer the depth of he'll if you don,t get off these. .
Side effects:   Read the above, no info..
Comments:   No comment.

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Page last updated: 2014-11-30

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