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Atenolol and Chlorthalidone (Atenolol / Chlorthalidone) - Indications and Dosage



Atenolol and chlorthalidone tablets are indicated in the treatment of hypertension. This fixed dose combination drug is not indicated for initial therapy of hypertension. If the fixed dose combination represents the dose appropriate to the individual patient’s needs, it may be more convenient than the separate components.


DOSAGE MUST BE INDIVIDUALIZED (SEE INDICATIONS AND USAGE): Chlorthalidone is usually given at a dose of 25 mg daily; the usual initial dose of atenolol is 50 mg daily. Therefore, the initial dose should be one atenolol and chlorthalidone 50 mg-25 mg tablet given once a day. If an optimal response is not achieved, the dosage should be increased to one atenolol and chlorthalidone 100 mg-25 mg tablet given once a day.

When necessary, another antihypertensive agent may be added gradually beginning with 50% of the usual recommended starting dose to avoid an excessive fall in blood pressure.

Since atenolol is excreted via the kidneys, dosage should be adjusted in cases of severe impairment of renal function. No significant accumulation of atenolol occurs until creatinine clearance falls below 35 mL/min/1.73 m2 (normal range is 100-150 mL/min/1.73 m2); therefore, the following maximum dosages are recommended for patients with renal impairment.

Creatinine ClearanceAtenolol Elimination
(mL/min/1.73 m2)Half-life (hrs)Maximum Dosage
15-3516-2750 mg daily
<15>2750 mg every other day


Atenolol and Chlorthalidone Tablets USP, 50 mg-25 mg are 10/32”, scored, round, white tablets imprinted DAN 5782 supplied in bottles of 100.

Atenolol and Chlorthalidone Tablets USP, 100 mg-25 mg are 12/32”, unscored, round, white tablets imprinted DAN 5783 supplied in bottles of 100.

Dispense in a well-closed, light-resistant container with a child-resistant closure.

Store at 20°-25°C (68°-77°F). [See USP controlled room temprature.]

Protect from heat, light and moisture.

Watson Laboratories, Inc.
Corona, CA 92880 USA

Revised: June 2006

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