Media Articles Related to Atenolol and Chlorthalidone (Atenolol / Chlorthalidone)
EHRs Take Center Stage in Battle to Control Hypertension
Source: MedPageToday.com - medical news plus CME for physicians [2015.03.27]
(MedPage Today) -- "Home-grown" electronic health record largely credited for better BP control.
Hypertension Becoming More Deadly?
Source: MedPage Today Cardiovascular [2015.03.26]
(MedPage Today) -- Cited more often as a factor on death certificates.
Vitamin D 'ineffective as treatment for hypertension'
Source: Cardiovascular / Cardiology News From Medical News Today [2015.03.19]
Researchers report that vitamin D supplementation does not work as an antihypertensive agent and cannot be recommended to control high blood pressure.
ACC: Folate Supplements Cut Strokes in Hypertension
Source: MedPage Today Neurology [2015.03.19]
(MedPage Today) -- Hypertensive patients with low blood folate levels gain big benefit.
Expanding blood pressure screenings beyond primary care can improve hypertension detection
Source: Hypertension News From Medical News Today [2015.03.16]
Expanding blood pressure screenings to non-primary care settings can help identify more patients with high blood pressure, commonly called hypertension, and could contribute to better hypertension...
Published Studies Related to Atenolol and Chlorthalidone (Atenolol / Chlorthalidone)
Antihypertensive therapy with verapamil SR plus trandolapril versus atenolol plus chlorthalidone on glycemic control. [2003.05]
BACKGROUND: There is evidence that diuretics and beta blockers impair glucose tolerance, whereas calcium channel blockers and angiotensin converting enzyme blockers lack this metabolic effect. We compared the effect of a combination therapy with a nondihydropyridine calcium channel blocker plus an angiotensin converting enzyme inhibitor and a beta blocker plus a diuretic on hemoglobin A(1c) (Hb A(1c)) in patients with type 2 diabetes and mild-to- moderate hypertension... CONCLUSIONS: HbA(1c) and other parameters of short- and long-term glycemic control were in a more favorable range after antihypertensive treatment with verapamil SR plus trandolapril as compared with atenolol plus chlorthalidone.
Effect of atenolol and reserpine on selected events in the systolic hypertension in the elderly program (SHEP). [1995.12]
The effect of atenolol and reserpine on incidence of strokes, coronary heart disease (CHD), cardiovascular disease (CVD), and mortality was assessed in 4736 persons aged 60 years and older with isolated systolic hypertension. Participants were randomized to either chlorthalidone (2371), with step-up to atenolol, or reserpine if needed, or placebo (2365)...
Randomised double-blind comparative study of efficacy and safety of hydroflumethiazide and reserpine and chlortalidone and atenolol in the treatment of mild to moderate hypertension in black patients. [1993.10]
This randomised, double-blind study compared the efficacy and safety of a fixed combination of hydroflumethiazide 50 mg and reserpine 0.125 mg (H-R) and chlortalidone 12.5 mg and atenolol 50 mg (C-A) in adult black patients with mild to moderate hypertension (a resting supine diastolic blood pressure (DBP) between 95 and 115 mmHg after a two week placebo washout period)...
Comparative effects of enalapril, atenolol and chlorthalidone on blood pressure and kidney function of diabetic patients affected by arterial hypertension and persistent proteinuria. 
Arterial hypertension and proteinuric nephropathy are common features in diabetic patients. In streptozotocin-diabetic rats, it has been possible to reduce the blood pressure and proteinuria by converting enzyme inhibitors, and so slowing the decline of kidney function... According to these results we can hypothesize that the inhibition of tissue angiotensin formation and its related change on the glomerular permeability, rather than renal and systemic hemodynamic features, seem to be the common mechanisms by which both enalapril as well as atenolol decrease the albuminuria in our patients.
[A comparative study of atenolol (Tenormin) and the combined preparation atenolol/chlorthalidone (Tenoretic Mite) in essential hypertension. A randomized double-blind study from general practice] [1990.04.09]
Two hundred and ninety-two hypertensive patients from general practice who had previously been treated with a diuretic with insufficient effect participated in a randomised trial for a period of three months. A total of 115 patients completed treatment with 50 mg atenolol (Tanormin) and 121 were treated with the combined preparation consisting of 50 mg atenolol and 12.5 mg chlothalidone (Tenoretic Mite) while 56 patients defected from the trial.
Clinical Trials Related to Atenolol and Chlorthalidone (Atenolol / Chlorthalidone)
Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome [Recruiting]
Marfan syndrome is an inherited connective tissue disorder with morbidity and mortality from
aortic dilation and dissection. The degree of aortic dilation and response to beta-blockade
(standard of care) vary in adults with Marfan syndrome. However, aortic stiffness is often
present, and can be a predictor of aortic dilation and cardiovascular complications. In
addition, adults with Marfan syndrome develop left ventricular diastolic dysfunction, which
can progress to heart failure. Aortic stiffness and diastolic dysfunction are important and
logical therapeutic targets in adults with Marfan syndrome.
TGF-beta mediates disease pathogenesis in Marfan syndrome and contributes to aortic
stiffness. The angiotensin receptor blocker, losartan, inhibits TGF-beta activity and
reverses aortic wall pathology in a Marfan mouse model. Losartan also decreases aortic
stiffness and improves diastolic function in hypertension, renal disease and hypertrophic
This trial is a randomized, double-blind trial of 50 adults with Marfan syndrome, treated
with 6 months of atenolol vs. losartan. Arterial tonometry for aortic stiffness and
echocardiography for diastolic function will be performed at the beginning and end of
treatment. A blood draw for serum markers of extracellular matrix turnover and inflammation
will also be performed at 0 and 6 months. We plan to determine whether losartan decreases
aortic stiffness and left ventricular diastolic dysfunction significantly more than
A Randomized Controlled Study to Assess the Effects of Bisoprolol and Atenolol on Resting Heart Rate and Sympathetic Nervous System's Activity in Subjects With Essential Hypertension [Recruiting]
This is a phase IV, prospective, multi-centric and randomized controlled study to compare
the effects of bisoprolol and atenolol on resting heart rate (RHR) and sympathetic nervous
system's (SNS) activity in subjects with essential hypertension. A total of 192 subjects are
planned to be enrolled in various centers in China.
Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Plaques [Recruiting]
Nebivolol is a novel blood pressure lowering drug with an additional effect on the inner
lining of blood vessels to release a compound called nitric oxide that can relax blood
vessels. Atenolol is a blood pressure reducing agent without the ability to release nitric
oxide and effect additional blood vessel relaxation.
The goal of this proposal is to compare Nebivolol and Atenolol with respect to the following
- Plaque within arteries supplying the heart in terms of its volume and composition as
assessed by ultrasound within these arteries.
- Ability of small arteries in the heart to open up and deliver an enhanced blood supply
in response to drug called Adenosine (routinely used in the cardiac catheterization
laboratory) as assessed by pressure and flow detecting catheters within these arteries.
- Ability of the inner lining of arteries that supply the heart to release a relaxing
compound called nitric oxide in response to injection of Acetylcholine (also used in
the cardiac catheterization laboratory) as assessed by squirting dye into these
- Local forces that affect blood flow in the arteries supplying the heart as assessed by
superimposing the above data into complex maps created offline at Georgia Institute of
It is likely that Nebivolol causes the plaque within arteries supplying the heart to change
from the 'vulnerable' type to the 'stable' type plaque. There are several features of
"vulnerable plaques" that can be detected in arteries of the heart using intravascular
ultrasound (a small ultrasound camera that goes in the arteries of the heart). The
investigators hypothesis is that Nebivolol will prove superior to Atenolol in reducing
'vulnerable plaques', improve blood flow within the small arteries and the health of inner
lining of these arteries at the 1 year time point. The investigators plan to enroll 20
patients into the study (26 patient including dropouts) who will be randomized in a 1: 1
manner to Nebivolol Vs Atenolol for 1 year and repeat evaluation at that time point.
A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function [Recruiting]
This is a randomized, double-blind, placebo-controlled study comparing the efficacy of
nebivolol and atenolol at improving small artery elasticity and reducing cardiovacular
disease risk in subjects with early vascular disease. Approximately 75 subjects with
borderline/elevated blood pressures and impaired endothelial function, as measured by
arterial elasticity scores, will be recruited and assigned to treatment groups using a block
randomization scheme. Patients will be randomly allocated to nebivolol, atenolol or
placebo, and then followed for 9 months.
Effect of Carvedilol Controlled-Release (CR) and Atenolol on Central Blood Pressure [Recruiting]
The purpose of this research study is to determine whether atenolol or controlled release
carvedilol lower blood pressure in the body as effectively as in the arm. Blood pressure
measured in the aorta, a large blood vessel carrying blood away from the heart, may be a
better measure of the harmful effects of high blood pressure on the body's organs. In the
past, blood pressure has only been measured in the arms. However, blood pressure in the
arms may not accurately reflect the blood pressure in the aorta and thus may mislead doctors
treating high blood pressure. For this reason, we are testing whether two different
medications for blood pressure, both in a class called beta blockers, have similar effects
on blood pressure in the arm and aorta.
Reports of Suspected Atenolol and Chlorthalidone (Atenolol / Chlorthalidone) Side Effects
Drug Ineffective (7),
Acute Myocardial Infarction (5),
Coronary Artery Disease (5),
Chest Pain (4),
Cough (4), more >>