ATARAX SUMMARY
ATARAX®
hydroxyzine hydrochloride
TABLETS AND SYRUP
Hydroxyzine hydrochloride is designated chemically as 1-(p-chlorobenzhydryl) 4-[2-(2-hydroxyethoxy)-ethyl] piperazine dihydrochloride.
Atarax (hydroxyzine) is indicated for the following:
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested.
Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus.
As a sedative when used as premedication and following general anesthesia, Hydroxyzine may potentiate meperidine (Demerol®) and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent.
The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient.
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ATARAX NEWS HIGHLIGHTS
Published Studies Related to Atarax (Hydroxyzine)
Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments. [2008.12]
Peripheral anti-H1 and central nervous system (CNS) activities after single (day 1) and repeated (day 7) administrations of increasing doses of bilastine (BIL) were assessed in 20 healthy volunteers throughout a crossover, randomized, double-blind, placebo (PLA)-controlled study. Repeated doses of BIL 20, 40, or 80 mg and hydroxyzine [generic for Atarax] 25 mg (HYD) as positive standard were administered on 7 consecutive days...
Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. [2008.12]
Pharmacokinetic parameters of hydroxyzine [generic for Atarax] and its active metabolite cetirizine were determined after oral and intravenous administration of 2 mg kg(-1) of hydroxyzine to six healthy dogs. Plasma drug levels were determined with high-pressure liquid chromatography... Pharmacodynamic modelling predicted that maximal antihistamine effect would occur with twice daily oral administration of hydroxyzine at 2 mg kg(-1).
Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial. [2007.04]
OBJECTIVES: Sleep difficulty is common in minimal hepatic encephalopathy (HE) and the mechanisms are not fully elucidated. Dysregulated histamine neurotransmission is associated with an altered circadian rhythmicity that is partially restored following central histamine H1 receptor blockade in cirrhotic animals. We studied the effects of the histamine H1 blocker hydroxyzine [generic for Atarax] in sleep alterations in patients with cirrhosis in a double-blind, randomized controlled fashion... CONCLUSIONS: In contrast to placebo, hydroxyzine 25 mg at bedtime improved sleep behavior (subjectively and using wrist actigraphy) in patients with cirrhosis and minimal HE. The risk of precipitating overt HE warrants some caution when prescribing this drug.
[Hydroxyzine premedication does not alter bispectral index changes following etomidate induction of general anaesthesia] [2007.03]
OBJECTIVE: Various drugs including hydroxyzine [generic for Atarax] are preoperatively administered to facilitate the induction of general anaesthesia. We investigated the effect of hydroxyzine premedication on BIS-based etomidate induction of general anaesthesia... CONCLUSION: Oral weight-related hydroxyzine premedication does not alter BIS-based etomidate induction of GA.
Histamine H1 Blocker Hydroxyzine Improves Sleep in Patients With Cirrhosis and Minimal Hepatic Encephalopathy: A Randomized Controlled Pilot Trial. [2007.01.11]
OBJECTIVES: Sleep difficulty is common in minimal hepatic encephalopathy (HE) and the mechanisms are not fully elucidated. Dysregulated histamine neurotransmission is associated with an altered circadian rhythmicity that is partially restored following central histamine H1 receptor blockade in cirrhotic animals. We studied the effects of the histamine H1 blocker hydroxyzine [generic for Atarax] in sleep alterations in patients with cirrhosis in a double-blind, randomized controlled fashion... CONCLUSIONS: In contrast to placebo, hydroxyzine 25 mg at bedtime improved sleep behavior (subjectively and using wrist actigraphy) in patients with cirrhosis and minimal HE. The risk of precipitating overt HE warrants some caution when prescribing this drug. (Am J Gastroenterol 2007;102:1-10).
Clinical Trials Related to Atarax (Hydroxyzine)
Comparative Effects of Rupatadine 10 mg, Hydroxyzine 50 mg and Placebo on Actual Driving Performance [Terminated]
The primary objective of this study is to measure and compare the acute effects of rupatadine
10 mg, relative to placebo and hydroxyzine 50 mg as an active control on healthy volunteers’
performance on a standard over-the-road driving test and a car-following test.
A Bioequivalence Study of Docetaxel for Injectable Emulsion (ANX-514) in Patients With Advanced Cancer [Recruiting]
The purpose of this study is to compare an injectable emulsion form of docetaxel to Taxotere
in patients with advanced cancer.
POWS: Palonosetron/Ondansetron Opioid Withdrawal Study [Recruiting]
Opioid medications are commonly used for pain relief. When given over time, physical
dependence can occur. This results in unpleasant side effects--such as agitation and
nausea--if opioid medications are suddenly stopped. We are interested in knowing if a
medication named Ondansetron can help ease or prevent symptoms associated with opioid
withdrawal. We are also interested in knowing if a similar (but more potent FDA-approved
drug, palonosetron) can more effectively treat withdrawal symptoms with or without
combination with an antihistamine called hydroxyzine (vistaril).
A Bioequivalence Study of Vinorelbine Tartrate Injectable Emulsion in Patients With Advanced Cancer. [Completed]
This study is a randomized, single dose crossover comparison of the investigational product
with a Reference Product (vinorelbine tartrate injection, NAVELBINE®). The primary objective
is to demonstrate the equivalence of ANX-530 and the Reference Product, NAVELBINE.
A Clinical Trial of CoFactor Formulations and Leucovorin Administered Intravenously in Healthy, Adult Subjects. [Recruiting]
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ATARAX PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Atarax has an overall score of 1. The effectiveness score is 2 and the side effect score is 5. The scores are on ten point scale: 10 - best, 1 - worst.
| | Atarax review by 28 year old male patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Ineffective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | anxiety |
| Dosage & duration: | | 25mg taken 3 times a day for the period of 2 months |
| Other conditions: | | insomnia |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | oh there was benefits, I did not have allergys and my my heart rate was down. |
| Side effects: | | There was dry mouth and some insomnia.. I also felt I was having anxiety attacks |
| Comments: | | Well, it all started back when I was fishing for jims and johns google which nothing seemed static relativity bound night train into fox holes stuck like glue into a world of hybrid horses, far from the eye can see in marlboro land once before the blue moon on the buildings outer limit limo taxi service system. |
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| | Atarax review by 54 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | Hives |
| Dosage & duration: | | don't remember (dosage frequency: every day) for the period of a week |
| Other conditions: | | thyroid |
| Other drugs taken: | | synthroid | | |
Reported Results |
| Benefits: | | Synthroid aggravated my hives, tremendously. |
| Side effects: | | The front of my legs were hot, swollen, and rashy. |
| Comments: | | Atarax was prescribed for my hives, and the second day, I started having a bad reaction! |
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Page last updated: 2009-02-07
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