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Atarax (Hydroxyzine Hydrochloride) - Summary

 

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ATARAX SUMMARY

ATARAX®
hydroxyzine hydrochloride
TABLETS AND SYRUP

Hydroxyzine hydrochloride is designated chemically as 1-(p-chlorobenzhydryl) 4-[2-(2-hydroxyethoxy)-ethyl] piperazine dihydrochloride.

Atarax (hydroxyzine) is indicated for the following:

For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested.

Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus.

As a sedative when used as premedication and following general anesthesia, Hydroxyzine may potentiate meperidine (Demerol®) and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent.

The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient.

ATARAX NEWS HIGHLIGHTS

Published Studies Related to Atarax (Hydroxyzine)

Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial. [2007.04]

[Hydroxyzine premedication does not alter bispectral index changes following etomidate induction of general anaesthesia] [2007.03]

Histamine H1 Blocker Hydroxyzine Improves Sleep in Patients With Cirrhosis and Minimal Hepatic Encephalopathy: A Randomized Controlled Pilot Trial. [2007.01.11]

Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. [2007]

A prospective study of 2 sedation regimens in children: chloral hydrate, meperidine, and hydroxyzine versus midazolam, meperidine, and hydroxyzine. [2006.09]

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Clinical Trials Related to Atarax (Hydroxyzine)

Comparative Effects of Rupatadine 10 mg, Hydroxyzine 50 mg and Placebo on Actual Driving Performance [Terminated]

A Bioequivalence Study of Docetaxel for Injectable Emulsion (ANX-514) in Patients With Advanced Cancer [Recruiting]

POWS: Palonosetron/Ondansetron Opioid Withdrawal Study [Recruiting]

Neurocognitive Functioning Following The PROMETA® Treatment Protocol In Subjects With Alcohol Dependence [Recruiting]

A Bioequivalence Study of Vinorelbine Tartrate Injectable Emulsion in Patients With Advanced Cancer. [Completed]

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Page last updated: 2007-10-18

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