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Atacand (Candesartan Cilexetil) - Summary

 
 



WARNING: FETAL TOXICITY

  • •When pregnancy is detected, discontinue ATACAND as soon as possible.
  • •Drugs that directly on the renin-angiotensin system can cause injury and death to the developing fetus.
 

ATACAND SUMMARY

ATACAND (candesartan cilexetil), a prodrug, is hydrolyzed to candesartan during absorption from the gastrointestinal tract. Candesartan is a selective AT1 subtype angiotensin II receptor antagonist.

Hypertension

ATACAND is indicated for the treatment of hypertension in adults and children 1 to < 17 years of age. It may be used alone or in combination with other antihypertensive agents.

Heart Failure

ATACAND is indicated for the treatment of heart failure (NYHA class II-IV) in adults with left ventricular systolic dysfunction (ejection fraction ≤ 40%) to reduce cardiovascular death and to reduce heart failure hospitalizations [see CLINICAL STUDIES]. ATACAND also has an added effect on these outcomes when used with an ACE inhibitor.


See all Atacand indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Atacand (Candesartan Cilexetil)

Combination Therapy Improves Pulmonary Hypertension Outcomes
Source: Medscape Medical News Headlines [2016.05.20]
Combination therapy reduces the risk of clinical worsening in idiopathic and connective-tissue-associated pulmonary arterial hypertension better than monotherapy, according to a new meta-analysis.
Medscape Medical News

Hypertension in Pregnancy Ups Intellectual Disability, ASD Risk
Source: Medscape Psychiatry & Mental Health Headlines [2016.05.19]
Children born of mothers who have any form of hypertension during pregnancy are at elevated risk for intellectual disability and autism.
Medscape Medical News

American Society of Hypertension (ASH) 2016 Annual Scientific Meeting
Source: theheart.org | Medscape Cardiology Headlines [2016.05.17]
Read clinically focused news coverage of key developments from ASH 2016.
theheart.org on Medscape

Around-the-clock monitoring may unmask hypertension in African-Americans
Source: Hypertension News From Medical News Today [2016.05.17]
Ambulatory blood pressure monitoring, a device which measures blood pressure around-the-clock may help identify African Americans who have "masked" or undetected high blood pressure.

High Blood Pressure (Hypertension): Warning Signs, Risks, Medications
Source: MedicineNet Nosebleed Specialty [2016.05.13]
Title: High Blood Pressure (Hypertension): Warning Signs, Risks, Medications
Category: Slideshows
Created: 3/9/2011 12:10:00 PM
Last Editorial Review: 5/13/2016 12:00:00 AM

more news >>

Published Studies Related to Atacand (Candesartan Cilexetil)

Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I-II essential hypertension: a randomized, double-blind clinical study. [2012]
Azilsartan is a novel angiotensin receptor blocker being developed for hypertension treatment. This 16-week, multicenter, randomized, double-blind study compared the efficacy and safety of azilsartan (20-40 mg once daily by forced titration) and its ability to provide 24-h blood pressure (BP) control, with that of candesartan cilexetil (candesartan; 8-12 mg once daily by forced titration) in 622 Japanese patients with grade I-II essential hypertension.

Efficacy and safety of combination therapy with candesartan cilexetil and pioglitazone hydrochloride in patients with hypertension and type 2 diabetes mellitus. [2011]
hypertension and type 2 diabetes mellitus... CONCLUSION: CC/PIO combination therapy improved BP/glycemic control and was well

Efficacy, safety and pharmacokinetics of candesartan cilexetil in hypertensive children from 1 to less than 6 years of age. [2010.05]
CONCLUSION: Candesartan cilexetil dose-dependently decreases blood pressure and albuminuria in hypertensive infants and is generally well tolerated.

Candesartan improves blood pressure control and reduces proteinuria in renal transplant recipients: results from SECRET. [2010.03]
BACKGROUND: Hypertension is a risk factor for the two leading causes of death in renal transplant recipients: cardiovascular disease (CVD) and graft failure. Despite this, the optimum medication for post-transplant hypertension is unclear... CONCLUSIONS: SECRET provides insights into the design and conduct of studies in this area and evidence for the utility of candesartan, which showed good safety and tolerability, improved BP control and decreased proteinuria in renal transplant recipients.

Effect of telmisartan, valsartan and candesartan on mycophenolate mofetil pharmacokinetics in Japanese renal transplant recipients. [2009.12]
OBJECTIVE: The aim of this study was to elucidate the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activating angiotensin receptor blocker (ARB) telmisartan and the non-PPAR-gamma activating ARB valsartan and candesartan on mycophenolic acid (MPA) pharmacokinetics in renal transplant recipients... CONCLUSIONS: The degree of drug interaction between MPA and telmisartan was significantly greater than that between MPA and valsartan or candesartan. Uridine diphosphate-glucuronosyltransferase (UGT) 1A9 has been identified as a PPAR-gamma target gene. UGT induction by telmisartan might stimulate MPA glucuronidation. A combination of telmisartan and mycophenolate mofetil might require periodic monitoring of MPA.

more studies >>

Clinical Trials Related to Atacand (Candesartan Cilexetil)

CKD-330 Drug-Drug Interaction Study (Candesartan) [Completed]
The purpose of this study is to evaluate a pharmacokinetic drug interaction and safety of Candesartan between free combination of Candesartan and Amlodipine and Candesartan monotherapy.

Atacand Dose Ranging in Hypertensive Pediatric Subjects 1 Year to Less Than 6 Years of Age [Completed]
This is a dose ranging study of candesartan cilexetil in hypertensive pediatric subjects ages 1 to less than 6 years of age. It employs a double blind, randomized, dose ranging design intended for conduct as a multicenter trial. There are 3 study 'periods': a 1-week placebo run-in, a 4-week double blind treatment, and a 52-week open-label, long-term treatment period. Subjects undergo a screening evaluation, then a 1-week single-blind, placebo run-in, after which eligible subjects are allocated to receive 1 of 3 dose levels of candesartan cilexetil (0. 05 mg/kg, or 0. 20 mg /kg or 0. 40 mg /kg), liquid formulation, in a 1: 1:1 ratio for 4-weeks. At the end of randomized dose allocation (Day 28), blood pressure assessment will be performed and subjects may begin the 52-week, open-label treatment period of the study.

ARIA (Atacand Renoprotection In NephropAthy Pt.) [Completed]
To determine the effective dose of candesartan cilexetil for reduction of urinary protein excretion in hypertensive patients with non-diabetic chronic kidney disease with baseline urinary protein/creatinine ratio between 500mg/g and 5000mg/g, by assessing the change in urinary protein/creatinine ratio from baseline to the end of 28-week treatment

Evaluation of the Pharmacokinetic Interaction Between Candesartan and Felodipine After Ingestion of a Specific Meal [Completed]
The purpose of this study is to evaluate the pharmacokinetic interaction of test formulations of candesartan and felodipine in a combination package comparing with the fasting intake of commercial formulations of both Atacand ® and Splendil®

Antihypertensive Efficacy and Safety of Candesartan/HCT 32/25 mg in Comparison With Individual Components and Placebo [Completed]
The aim is to compare the blood pressure lowering effect of the combination of candesartan cilexetil (candesartan) 32 mg and hydrochlorothiazide (HCT) 25 mg to that of candesartan 32 mg alone, HCT 25 mg alone and placebo in hypertensive adults.

more trials >>

Reports of Suspected Atacand (Candesartan Cilexetil) Side Effects

Hypertension (126)Drug Ineffective (109)Malaise (101)Blood Pressure Increased (94)Drug Dose Omission (81)Dizziness (72)Cerebrovascular Accident (61)Headache (46)Diabetes Mellitus (40)Fall (40)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Atacand has an overall score of 9. The effectiveness score is 8.50 and the side effect score is 8.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Atacand review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   16mg taken once a day for the period of 2 years
Other conditions:   none
Other drugs taken:   no other drugs but on HRT
  
Reported Results
Benefits:   lowered blood pressure
Side effects:   I did experience some bowel changes although the doctor did not seem to think that this would be the result of the drug. I do, however. I experienced constipation.
Comments:   One 16 mg tablet to be taken daily. I had been given other blood pressure medication previously which I did not respond as well to so It took a few tries to get it right. I would like to be able to stop taking the medication and am trying to lose weight and lead a healthier lifestyle but all the literature seems to suggest that I may always need to take the medication.

 

Atacand review by 73 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   8 mg taken once per day for the period of several years
Other conditions:   none
Other drugs taken:   vitamins, folic acid, vit-D3
  
Reported Results
Benefits:   The Atacand worked well for me IF taken consistently without skipping days. I was able to bring my blood pressure to at least 120/80 and at times a bit lower. Note that consistency of medication is a key. Should the 8mg tablet taken once per day not prove as effective as desired, my physician advised that I could take an additional tablet or two per day without problem.
Side effects:   Did not notice any undesirable side effects. The only thing that could be mentioned is that if one embarks on a significant exercise routine such as elleptical stairstep machine for 30+ minutes/day and keeps up the exercise for weeks on end while at the same time taking the Atacand, one may end up with a [not undesirable] blood pressure in the 112/65 range.
Comments:   The Atacand worked well IF taken routinely without skipping days. It takes a while for the regulation to start, ie, you can't begin from scratch taking the Atacand the first morning and expect proper blood pressure regulation that afternoon. Doesn't work that quickly. There is a tendency, after taking the medication consistently and seeing your pressure get well under control, to think that maybe you can stop or at least taper off of the Atacand. One may try this but will find that the best regimen is consistency. It did work well for me and keeps me under 120/80.

 

Atacand review by 73 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   8 mg taken once per day for the period of several years
Other conditions:   none
Other drugs taken:   vitamins, folic acid, vit-D3
  
Reported Results
Benefits:   The Atacand worked well for me IF taken consistently without skipping days. I was able to bring my blood pressure to at least 120/80 and at times a bit lower. Note that consistency of medication is a key. Should the 8mg tablet taken once per day not prove as effective as desired, my physician advised that I could take an additional tablet or two per day without problem.
Side effects:   Did not notice any undesirable side effects. The only thing that could be mentioned is that if one embarks on a significant exercise routine such as elleptical stairstep machine for 30+ minutes/day and keeps up the exercise for weeks on end while at the same time taking the Atacand, one may end up with a [not undesirable] blood pressure in the 112/65 range.
Comments:   The Atacand worked well IF taken routinely without skipping days. It takes a while for the regulation to start, ie, you can't begin from scratch taking the Atacand the first morning and expect proper blood pressure regulation that afternoon. Doesn't work that quickly. There is a tendency, after taking the medication consistently and seeing your pressure get well under control, to think that maybe you can stop or at least taper off of the Atacand. One may try this but will find that the best regimen is consistency. It did work well for me and keeps me under 120/80.

See all Atacand reviews / ratings >>

Page last updated: 2016-05-20

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