Media Articles Related to Atacand HCT (Candesartan Cilexetil / Hydrochlorothiazide)
Pharmacists help patients with hypertension
Source: Hypertension News From Medical News Today [2015.07.31]
If you have hypertension, it pays to include a pharmacist in a medical care team.
Food container plastics linked to hypertension
Source: Hypertension News From Medical News Today [2015.07.09]
Plastic food containers and wraps containing phthalates were associated with hypertension and insulin resistance in two new studies investigating the chemicals.
Hypertension, high cholesterol, other heart disease risk factors increasing In Asia
Source: Cholesterol News From Medical News Today [2015.07.07]
Research efforts, data collection vital to improved treatmentThe prevalence of cardiovascular risk factors like hypertension, high cholesterol, and diabetes have been decreasing in the United...
Two new studies on the connection between hypertension and cognitive decline
Source: Hypertension News From Medical News Today [2015.07.03]
With the number of individuals affected by cognitive decline expected to rise over the next few decades, investigating its potential causes is of major public health interest.
Source: MedicineNet Cirrhosis Specialty [2015.05.29]
Title: Portal Hypertension
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 5/29/2015 12:00:00 AM
Published Studies Related to Atacand HCT (Candesartan Cilexetil / Hydrochlorothiazide)
Effects of candesartan cilexetil on carotid remodeling in hypertensive diabetic patients: the MITEC study. 
In hypertension and diabetes, early structural changes of the arterial wall precede or support atherosclerosis... The results of this study show that CC and AML treatments may alter identically the natural progression of carotid IMT in hypertensive type 2 diabetic patients.
Combination therapy with candesartan cilexetil 32 mg and hydrochlorothiazide 25 mg provides the full additive antihypertensive effect of the components: A randomized, double-blind, parallel-group study in primary care. 
BACKGROUND AND OBJECTIVE: Fixed-combination tablets of candesartan (orally administered as the pro-drug candesartan cilexetil and hereafter referred to as candesartan) and hydrochlorothiazide (HCTZ) 8/12.5 mg and 16/12.5 mg are effective and well tolerated. However, some patients require higher doses to attain target blood pressure, and combination tablets containing candesartan and HCTZ at the upper end of their respective dose ranges are now being developed. This study aimed to assess the antihypertensive effect and tolerability of the combination of candesartan 32 mg and HCTZ 25 mg versus candesartan 32 mg monotherapy, HCTZ 25 mg monotherapy, and placebo... CONCLUSION: The antihypertensive effect of candesartan/HCTZ 32/25 mg represents fully additive contributions from each of its components, and is generally well tolerated in patients with mild to moderate primary hypertension. This combination adds to the treatment options for improving blood pressure control in patients with hypertension.
Antihypertensive efficacy and tolerability of candesartan-hydrochlorothiazide 32/12.5 mg and 32/25 mg in patients not optimally controlled with candesartan monotherapy. [2008.12]
AIM: To evaluate the efficacy and tolerability of candesartan cilexetil 32 mg in combination with hydrochlorothiazide (HCT) 12.5 mg or 25 mg in hypertensive patients not optimally controlled with candesartan monotherapy... CONCLUSION: Candesartan-HCT 32/12.5 mg and candesartan-HCT 32/25 mg are highly effective and provide improved blood pressure reduction and blood pressure control relative to candesartan 32 mg monotherapy, with maintained tolerability, in hypertensive patients whose blood pressure is not optimally controlled with candesartan monotherapy. Furthermore, candesartan-HCT 32/25 mg is more effective than candesartan-HCT 32/12.5 mg in this population.
[Investigations of the antihypertensive long-term action of candesartan cilexetil in different dosages under the influence of therapy-free intervals] 
INTRODUCTION: In a randomized, phase IV clinical study with 4 parallel treatment arms, the long-lasting treatment effect of candesartan cilexetil (CAS 145040-37-5, CC, Blopress) was to be demonstrated for a repeated therapy-free interval of 48 h in the dosages 8 and 16 mg with or without hydrochlorothiazide 12.5 mg (CAS 58-93-5, HCT; 4 groups totally). The reason for this design was the known possibility of missed tablet doses in the patients' daily practice leading to a not always sufficient lowering of blood pressure in essential hypertension. Therefore, the intake of the daily tablet dose was intentionally omitted twice (after 6 and 8 weeks) during the 8-week study treatment period... CONCLUSIONS: The objectives of the present study were completely met by confirming statistically and clinically the assumption of a clear, long-lasting, safe and metabolically neutral action of CC both for low and high dosages with or without HCT. The intended lowering of blood pressure is effective and well tolerable also repeatedly during the 48-h, therapy-free interval (missed dose trial) which corresponds to a frequent omission of the daily tablet dose and thus well reflects the daily practice in antihypertensive therapeutic regimens.
Candesartan plus hydrochlorothiazide fixed combination vs previous monotherapy plus diuretic in poorly controlled essential hypertensive patients. [2004.12]
OBJECTIVE: To assess efficacy and tolerability of candesartan cilexetil (CC) plus hydrochlorothiazide (HCTZ) fixed combination vs previous monotherapy (PM) plus HCTZ in hypertension... CONCLUSIONS: CC plus HCTZ fixed combination is an effective and safe alternative to other antihypertensive drugs, given either as monotherapy or in combination when they do not satisfactorily control patient's blood pressure.
Clinical Trials Related to Atacand HCT (Candesartan Cilexetil / Hydrochlorothiazide)
Atacand Dose Ranging in Hypertensive Pediatric Subjects 1 Year to Less Than 6 Years of Age [Active, not recruiting]
This is a dose ranging study of candesartan cilexetil in hypertensive pediatric subjects ages
1 to less than 6 years of age. It employs a double blind, randomized, dose ranging design
intended for conduct as a multicenter trial. There are 3 study 'periods': a 1-week placebo
run-in, a 4-week double blind treatment, and a 52-week open-label, long-term treatment
period. Subjects undergo a screening evaluation, then a 1-week single-blind, placebo run-in,
after which eligible subjects are allocated to receive 1 of 3 dose levels of candesartan
cilexetil (0. 05 mg/kg, or 0. 20 mg /kg or 0. 40 mg /kg), liquid formulation, in a 1: 1:1 ratio
for 4-weeks. At the end of randomized dose allocation (Day 28), blood pressure assessment
will be performed and subjects may begin the 52-week, open-label treatment period of the
Compliance of Patients With Essential Hypertension Treated With Candesartan or Candesartan/Hydrochlorothiazide [Completed]
The CoCa study with at maximum daily dose of 32 mg candesartan or 16/12. 5 mg
candesartan/hydrochlorothiazide has the objective to evaluate under naturalistic conditions,
i. e. under routine medical care conditions, the subject compliance as well as the efficacy
and tolerability of candesartan or candesartan/HCT in subjects suffering from essential
Candesartan and Candesartan/ Hydrochlorothiazide in the Treatment of Patients With Hypertension and LVH [Completed]
The CandLE study with at maximum daily dose of 32 mg candesartan or 16/12. 5 mg
candesartan/hydrochlorothiazide has the objective to evaluate under naturalistic conditions,
i. e. under routine medical care conditions, the impact of the antihypertensive therapy with
candesartan or candesartan/HCT on relevant medical parameters related to the left ventricular
hypertrophy (LVH) as well as the efficacy and tolerability of candesartan or candesartan/HCT
in subjects suffering from essential hypertension..
DIabetic Retinopathy Candesartan Trials. [Active, not recruiting]
The primary objective is to determine whether candesartan, compared to placebo reduces the
progression of diabetic retinopathy in normotensive, normoalbuminuric type 1 diabetic
patients with retinopathy.
The secondary objective is to determine whether candesartan, compared to placebo, reduces
the incidence of clinically significant macular oedema (CSME) and/or proliferative diabetic
retinopathy (PDR) and beneficially influences the rate of change in urinary albumin excretion
This study is part of the DIRECT Programme also including a primary prevention study of
diabetic retinopathy in type 1 diabetes and a secondary prevention study in type 2 diabetes.
The primary objective for all three pooled studies is to determine whether candesartan,
compared to placebo, reduces the incidence of microalbuminuria in type 1 and type 2 diabetic
Antihypertensive Efficacy and Safety of Candesartan/HCT 32/12.5 and 32/25 mg in Comparison With Candesartan 32 mg [Completed]
In this study it is intended to compare the blood pressure lowering effect of the combination
of candesartan cilexetil (candesartan) 32 mg and hydrochlorothiazide (HCT) 25 mg and the
combination of candesartan 32 mg and HCT 12. 5 mg to that of candesartan 32 mg alone in
patients whose blood pressure is not well controlled on candesartan 32 mg monotherapy. The
Primary Objectives are to compare sitting BP lowering effect of candesartan/HCT 32/25 mg and
candesartan/HCT 32/12. 5 mg with that of candesartan 32 mg, respectively.
Reports of Suspected Atacand HCT (Candesartan Cilexetil / Hydrochlorothiazide) Side Effects
Drug Ineffective (77),
Blood Pressure Increased (57),
Drug Dose Omission (44),
Cerebrovascular Accident (25),
Blood Pressure Inadequately Controlled (21),
Oedema Peripheral (21),
Headache (20), more >>