Media Articles Related to Astramorph (Morphine Epidural)
Europe Again Says HPV Vax Safe, but Petition in Spain
Source: Medscape Hematology-Oncology Headlines [2015.11.20]
Europe has again said that HPV vaccination is safe and that it is not causally linked to chronic syndromes, but some doctors remain unconvinced.
Medscape Medical News
FDA Approves Nasal Spray to Reverse Narcotic Painkiller Overdose
Source: MedicineNet Drug Abuse Specialty [2015.11.20]
Title: FDA Approves Nasal Spray to Reverse Narcotic Painkiller Overdose
Category: Health News
Created: 11/19/2015 12:00:00 AM
Last Editorial Review: 11/20/2015 12:00:00 AM
Ibandronate vs Radiotherapy for Bone Pain in Prostate Cancer
Source: Medscape Orthopaedics Headlines [2015.11.19]
Compare choices for treatment of metastatic prostate cancer related bone pain.
Journal of the National Cancer Institute
Proximal Muscle Rehabilitation for Patellofemoral Pain
Source: Medscape Orthopaedics Headlines [2015.11.19]
How do these rehabilitation protocols for patellofemoral pain compare in terms of pain reduction and improved function?
British Journal of Sports Medicine
Upsurge in Female Opioid Addiction Tied to Prescribed Pain Meds
Source: Medscape Psychiatry & Mental Health Headlines [2015.11.19]
Women are disproportionately affected by opioid addiction from prescription painkillers, new research shows.
Medscape Medical News
Published Studies Related to Astramorph (Morphine Epidural)
Evaluation of a single-dose, extended-release epidural morphine formulation for
pain control after lumbar spine surgery. 
DepoDur, an extended-release epidural morphine, has been used effectively for
postoperative pain control following many orthopaedic and general surgery
procedures and has provided prolonged analgesia when compared with Duramorph. The
goal of this article was to compare the safety and analgesic efficacy of DepoDur
versus Duramorph after lumbar spine surgery...
Transversus abdominis plane block versus perioperative intravenous lidocaine
versus patient-controlled intravenous morphine for postoperative pain control
after laparoscopic colorectal surgery: study protocol for a prospective,
randomized, double-blind controlled clinical trial. 
BACKGROUND: Despite the laparoscopic approach becoming the standard in colorectal
surgery, postoperative pain management for minimally invasive surgery is still
mainly based on strategies that have been established for open surgical
procedures... DISCUSSION: Recognizing the importance of a multimodal approach for perioperative
pain management, we aim to investigate whether a transversus abdominis plane
block delivers superior pain control in comparison to perioperative intravenous
lidocaine and patient-controlled intravenous analgesia with morphine alone.
Transversus abdominis plane block reduces morphine consumption in the early
postoperative period following microsurgical abdominal tissue breast
reconstruction: a double-blind, placebo-controlled, randomized trial. 
in a randomized controlled trial... CONCLUSION: Following abdominally based breast reconstruction, transversus
Ropivacaine Continuous Wound Infusion Versus Epidural Morphine for Postoperative Analgesia After Cesarean Delivery: A Randomized Controlled Trial. [2011.10.24]
Background:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Methods:Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study...
Prior epidural lidocaine alters the pharmacokinetics and drug effects of extended-release epidural morphine (DepoDur(R)) after cesarean delivery. [2011.08]
BACKGROUND: A potential physicochemical interaction between epidural local anesthetics and extended-release epidural morphine (EREM) could negate the sustained release. In this study, we sought to determine the pharmacokinetic and drug effects of prior epidural lidocaine administration on EREM... CONCLUSION: A large dose of epidural lidocaine 1 hour before EREM administration alters the pharmacokinetics and drug effects of EREM. Clinicians must apply caution when EREM is administered even 1 hour after an epidural lidocaine "top-up" for cesarean delivery.
Clinical Trials Related to Astramorph (Morphine Epidural)
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens [Completed]
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery
for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia
has been studied, but up to date no data are available concerning the use of thoracic
epidural patient-controlled analgesia regarding the use of levobupivacaine combined with
morphine in morbidly obese patients. The investigators' aim in this prospective,
randomized, double-blinded study was to compare the analgesic effectiveness, the dose
requirements and side effects of thoracic epidural patient controlled analgesia 0. 1% and
0. 2% levobupivacaine combined with a continuous epidural administration of morphine, with or
without a loading dose, after open gastric bypass for morbid obesity.
The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study [Completed]
The aim of our study is to define the median effective analgesic doses (ED50) of
paracetamol, morphine, and their combination and determination the nature of their
interaction administered IV for postoperative pain after moderate painful surgery using
up-and-down and isobolographic methods.
A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain [Recruiting]
The purpose of this study is to determine whether dexmedetomidine added to morphine is
effective in the treatment of chronic cancer pain.
Ketamine Associated With Morphine PCA After Total Hip Arthroplasty [Completed]
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid
Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that
ketamine administrated separately via a continuous infusion, could induced a better
We will perform a randomised double blind study to determine the best infusion mode of
intravenous ketamine, associated with morphine in PCA syringe or alone in continuous
Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section [Recruiting]
The cesarean section is considered as a painful surgery during the post operative period.
Mothers may need to move immediately after the surgery to take care of their babies. This
may increase the risk of major pain and chronic pain. Thus, excellent postoperative
analgesia is required so that mothers do not experience pain in caring for their baby.
Currently, several techniques have been developed to manage postoperative pain related to
c-section scar such as intrathecal morphine during spinal anesthesia or continuous
pre-peritoneal wound infiltration. The comparison between anesthetic techniques has never
been performed and it is still not know if the combination of intrathecal morphine plus
continuous pre-peritoneal wound infiltration provide a synergistic or additional effect on