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Astramorph (Morphine Sulfate Epidural) - Summary

 
 



ASTRAMORPH SUMMARY

ASTRAMORPH/PF™
(morphine sulfate injection, USP) Preservative-Free CS-ll

Morphine is the most important alkaloid of opium and is a phenanthrene derivative.

ASTRAMORPH (Morphine EPIDURAL) is indicated for the following:

Astramorph/PF is a systemic narcotic analgesic for administration by the intravenous, epidural or intrathecal routes. It is used for the management of pain not responsive to non-narcotic analgesics. Astramorph/PF, administered epidurally or intrathecally, provides pain relief for extended periods without attendant loss of motor, sensory or sympathetic function.


See all Astramorph indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Astramorph (Morphine Epidural)

Pain, Papular Lesions, a Trip to Pakistan: Crack the Case
Source: Medscape Infectious Diseases Headlines [2015.08.19]
Dr Paget discusses one of his recent patients who returned from a trip to Pakistan 5 years ago and since then has never been the same.
Medscape Rheumatology

NeuroBreak: OxyContin for Kids, Singing Away the Pain
Source: MedPage Today Neurology [2015.08.18]
(MedPage Today) -- News and commentary from the world of neurology and neuroscience

Florida Laws May Help Lower Abuse of Prescription Painkillers
Source: MedicineNet Chronic Pain Specialty [2015.08.18]
Title: Florida Laws May Help Lower Abuse of Prescription Painkillers
Category: Health News
Created: 8/17/2015 12:00:00 AM
Last Editorial Review: 8/18/2015 12:00:00 AM

25 Million U.S. Adults Struggle With Daily Pain
Source: MedicineNet Chronic Pain Specialty [2015.08.18]
Title: 25 Million U.S. Adults Struggle With Daily Pain
Category: Health News
Created: 8/18/2015 12:00:00 AM
Last Editorial Review: 8/18/2015 12:00:00 AM

Yeast's New Use: Making Narcotic Painkillers
Source: MedicineNet Chronic Pain Specialty [2015.08.14]
Title: Yeast's New Use: Making Narcotic Painkillers
Category: Health News
Created: 8/13/2015 12:00:00 AM
Last Editorial Review: 8/14/2015 12:00:00 AM

more news >>

Published Studies Related to Astramorph (Morphine Epidural)

Evaluation of a single-dose, extended-release epidural morphine formulation for pain control after lumbar spine surgery. [2014]
DepoDur, an extended-release epidural morphine, has been used effectively for postoperative pain control following many orthopaedic and general surgery procedures and has provided prolonged analgesia when compared with Duramorph. The goal of this article was to compare the safety and analgesic efficacy of DepoDur versus Duramorph after lumbar spine surgery...

Transversus abdominis plane block versus perioperative intravenous lidocaine versus patient-controlled intravenous morphine for postoperative pain control after laparoscopic colorectal surgery: study protocol for a prospective, randomized, double-blind controlled clinical trial. [2014]
BACKGROUND: Despite the laparoscopic approach becoming the standard in colorectal surgery, postoperative pain management for minimally invasive surgery is still mainly based on strategies that have been established for open surgical procedures... DISCUSSION: Recognizing the importance of a multimodal approach for perioperative pain management, we aim to investigate whether a transversus abdominis plane block delivers superior pain control in comparison to perioperative intravenous lidocaine and patient-controlled intravenous analgesia with morphine alone.

Transversus abdominis plane block reduces morphine consumption in the early postoperative period following microsurgical abdominal tissue breast reconstruction: a double-blind, placebo-controlled, randomized trial. [2014]
in a randomized controlled trial... CONCLUSION: Following abdominally based breast reconstruction, transversus

Ropivacaine Continuous Wound Infusion Versus Epidural Morphine for Postoperative Analgesia After Cesarean Delivery: A Randomized Controlled Trial. [2011.10.24]
Background:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Methods:Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study...

Prior epidural lidocaine alters the pharmacokinetics and drug effects of extended-release epidural morphine (DepoDur(R)) after cesarean delivery. [2011.08]
BACKGROUND: A potential physicochemical interaction between epidural local anesthetics and extended-release epidural morphine (EREM) could negate the sustained release. In this study, we sought to determine the pharmacokinetic and drug effects of prior epidural lidocaine administration on EREM... CONCLUSION: A large dose of epidural lidocaine 1 hour before EREM administration alters the pharmacokinetics and drug effects of EREM. Clinicians must apply caution when EREM is administered even 1 hour after an epidural lidocaine "top-up" for cesarean delivery.

more studies >>

Clinical Trials Related to Astramorph (Morphine Epidural)

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for treating moderate to severe chronic pain over a 12 week period.

INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX) and intravenously conducted in patients in a hospice care setting or through a palliative care medicine setting. In this within-patient controlled study, each eligible study patient receives a single injection by each of the three methods of morphine administration, sequentially on three consecutive days, according to the order specified by a randomization schedule.

Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be blinded, the two SC injections will be double-blinded, using the same volume of normal saline (0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.

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Page last updated: 2015-08-19

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