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Arimidex (Anastrozole) - Summary

 
 



ARIMIDEX SUMMARY

ARIMIDEX®
Anastrozole
TABLETS

ARIMIDEX® (anastrozole) tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor.

ARIMIDEX is indicated for adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer.

The effectiveness of ARIMIDEX in early breast cancer is based on an analysis of recurrence-free survival in patients treated for a median of 31 months (see CLINICAL PHARMACOLOGY -- Clinical Studies subsection). Further follow-up of study patients will be required to determine long-term outcomes.

ARIMIDEX is indicated for the first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer.

ARIMIDEX is indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. Patients with ER-negative disease and patients who did not respond to previous tamoxifen therapy rarely responded to ARIMIDEX.


See all Arimidex indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Arimidex (Anastrozole)

Decoding Breast Cancer Risk: BRCA and Beyond
Source: Medscape Hematology-Oncology Headlines [2014.10.16]
Dr Lidia Schapira talks with Dr Leif Ellisen about the controversy of widespread BRCA testing and the practical issues in assessing a woman's risk of developing breast and ovarian cancer.
Medscape Oncology

New treatment target identified for aggressive breast cancer
Source: Breast Cancer News From Medical News Today [2014.10.16]
One of the first-known oncogenes has a protein partner that helps breast cancer proliferate and when it's blocked, so is the cancer, scientists report.

Study finds potential link between breast cancer genes and salivary gland cancer
Source: Breast Cancer News From Medical News Today [2014.10.16]
The risk of developing cancer in a salivary gland might be higher in people with mutations in either of two genes associated with breast and ovarian cancer, according to a new study by researchers...

Healthy Lifestyle May Boost Breast Cancer Survival
Source: MedicineNet Nutrition Specialty [2014.10.16]
Title: Healthy Lifestyle May Boost Breast Cancer Survival
Category: Health News
Created: 10/16/2014 12:00:00 AM
Last Editorial Review: 10/16/2014 12:00:00 AM

Medicare Subsidy Helps Breast Cancer Patients Afford Treatment
Source: MedicineNet Hormone Therapy Specialty [2014.10.15]
Title: Medicare Subsidy Helps Breast Cancer Patients Afford Treatment
Category: Health News
Created: 10/15/2014 12:00:00 AM
Last Editorial Review: 10/15/2014 12:00:00 AM

more news >>

Published Studies Related to Arimidex (Anastrozole)

Lipid profiles within the SABRE trial of anastrozole with and without risedronate. [2012]
Lipid profiles in women with early breast cancer receiving anastrozole with or without risedronate were examined within an international Phase III/IV study to assess for possible treatment related changes. Postmenopausal women with hormone receptor-positive breast cancer were assigned to 1 of 3 strata by risk of fragility fracture...

Weight change associated with anastrozole and tamoxifen treatment in postmenopausal women with or at high risk of developing breast cancer. [2012]
Weight gain is commonly reported by breast cancer patients on tamoxifen or aromatase inhibitors. Since weight gain may impact on outcome and compliance we have prospectively assessed the effects of these agents on weight change in three randomised trials for the treatment or prevention of breast cancer...

Pharmacokinetic comparison of 2 formulations of anastrozole (1 mg) in healthy Korean male volunteers: a randomized, single-dose, 2-period, 2-sequence, crossover study. [2012]
formulations in healthy male adult volunteers... CONCLUSION: The test and reference formulations had similar PK parameters and

Neoadjuvant anastrozole versus tamoxifen in patients receiving goserelin for premenopausal breast cancer (STAGE): a double-blind, randomised phase 3 trial. [2012]
goserelin for early breast cancer in the neoadjuvant setting... INTERPRETATION: Given its favourable risk-benefit profile, the combination of

Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype--ACOSOG Z1031. [2011.06.10]
PURPOSE: Preoperative aromatase inhibitor (AI) treatment promotes breast-conserving surgery (BCS) for estrogen receptor (ER)-positive breast cancer. To study this treatment option, responses to three AIs were compared in a randomized phase II neoadjuvant trial designed to select agents for phase III investigations... CONCLUSION: Neoadjuvant AI treatment markedly improved surgical outcomes. Ki67 and PEPI data demonstrated that the three agents tested are biologically equivalent and therefore likely to have similar adjuvant activities. LumA tumors were more likely to have favorable biomarker characteristics after treatment; however, occasional paradoxical increases in Ki67 (12% of tumors with > 5% increase after therapy) suggest treatment-resistant cells, present in some LumA tumors, can be detected by post-treatment profiling.

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Clinical Trials Related to Arimidex (Anastrozole)

Iressa (ZD1839) Plus Anastrozole (Arimidex) in Patients With Ovarian Cancer [Completed]
The main purpose of this study is to determine the effects (good and bad) Iressa plus anastrozole has on patients with relapsed ovarian cancer.

Gynecomastia Extension Study [Completed]
The purpose of this study is to look at the effect of anastrozole (ZD1033, Arimidex™) in reducing gynecomastia in pubertal boys treated with placebo in Trial 1033US/0006 (another anastrozole study).

Ax-003/Arimidex (Anastrozole) in the Adjuvant Therapy of Early Breast Cancer [Completed]
The purpose of this study is the initial/followed by 5 year adjuvant therapy with Anastrozole.

Arimidex/Faslodex/Iressa Study: A Trial Using Arimidex, Faslodex and Iressa in Women With Breast Cancer [Active, not recruiting]
The investigators want to know if combining Arimidex and Faslodex with Iressa will be an effective treatment for breast cancer. They also want to know, using special tests on the tumor, the changes that occur with the treatment so they can try to improve their treatment for breast cancer in the future.

Open Label Arimidex in Gynecomastia [Completed]
The purpose of this study is to evaluate the safety, effectiveness, pharmacokinetics and pharmacodynamics of anastrozole (ARIMIDEX™) in the treatment of boys with gynecomastia.

more trials >>

Reports of Suspected Arimidex (Anastrozole) Side Effects

Arthralgia (123)Neoplasm Malignant (113)Malaise (86)Hot Flush (79)Breast Cancer (78)Pain in Extremity (67)Fall (66)Drug Dose Omission (63)Fatigue (58)Alopecia (56)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Arimidex has an overall score of 9. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
 

Arimidex review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   post breast cancer
Dosage & duration:   1mg taken once a day for the period of 5 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Considered beneficial for post menapausal women to prevent the recurrance of breast cancer. It is a hormone blocker that stops the production of estrogen. Many breast cancer tumors are estrogen positive and thrive in the presence of estrogen.
Side effects:   I had no side effects but possible side effects are, constipation, headaches, nausea, diahrea, weight gain.
Comments:   One 1mg pill once a day for five years following treatment of breast cancer in post menapausal women.

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Page last updated: 2014-10-16

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