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Aricept (Donepezil Hydrochloride) - Summary

 
 



ARICEPT SUMMARY

ARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1 H -inden-1-one hydrochloride. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020.

ARICEPT is indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's disease.


See all Aricept indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Aricept (Donepezil)

ARICEPT (Donepezil) effective for severe Alzheimer's disease
Source: The Doctors Lounge - Neurology
Donepezil reverses some aspects of cognitive deterioration seen in severe Alzheimer's disease.

Medical News Today: Fat deposits in brain may hasten Alzheimer's disease
Source: Featured Health News from Medical News Today [2015.08.28]
New research suggests that abnormal fat deposits found in the brains of people who died from Alzheimer's disease could trigger or accelerate the condition.

Fat deposits in brain may hasten Alzheimer's disease
Source: Biology / Biochemistry News From Medical News Today [2015.08.28]
New research suggests that abnormal fat deposits found in the brains of people who died from Alzheimer's disease could trigger or accelerate the condition.

Waterford research on Alzheimer's disease suggests that measuring macular pigment offers potential as a biomarker of cognitive health
Source: Eye Health / Blindness News From Medical News Today [2015.08.25]
Results to be showcased internationally in the Journal of Alzheimer's DiseaseOngoing European Research Council-funded research at Waterford Institute of Technology's (WIT) Macular Pigment...

UNMC statewide study to test new model for caregivers of those with Alzheimer's disease, dementia
Source: Caregivers / Homecare News From Medical News Today [2015.08.20]
The responsibility of caring for loved ones with Alzheimer's disease or dementia can be overwhelming - physically, mentally and financially.

more news >>

Published Studies Related to Aricept (Donepezil)

The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial. [2014]
This double-blind, placebo-controlled, 3-period cross-over, 4-treatment option, incomplete block study (ClinicalTrials.gov number NCT01485185), with an adaptive design for sample size re-estimation, was designed to evaluate gabapentin plus donepezil in an established experimental model of electrical hyperalgesia...

Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: a systematic review and meta-analysis. [2014]
rivastigmine, and memantine for the treatment of AD... CONCLUSIONS: Cholinesterase inhibitors and memantine are able to stabilize or

Evaluation of an 8-item Severe Impairment Battery (SIB-8) vs. the full SIB in moderate to severe Alzheimer's disease patients participating in a donepezil study. [2013]
explored the SIB-8 scale with respect to its validity and sensitivity... CONCLUSIONS: In this post hoc analysis, similar treatment effects were measured

Ventricular enlargement and its clinical correlates in the imaging cohort from the ADCS MCI donepezil/vitamin E study. [2013]
We analyzed the baseline and 3-year T1-weighted magnetic resonance imaging data of 110 amnestic mild cognitive impairment (MCI) participants with minimal hippocampal atrophy at baseline from the Alzheimer's Disease Cooperative Study group MCI Donepezil/Vitamin E trial... Executive decline was associated with right frontal and left temporal horn enlargement.

Donepezil and memantine for moderate-to-severe Alzheimer's disease. [2012]
disease... CONCLUSIONS: In patients with moderate or severe Alzheimer's disease, continued

more studies >>

Clinical Trials Related to Aricept (Donepezil)

Aricept to Improve Functional Tasks in Vascular Dementia [Active, not recruiting]
Medications for memory improvement are available but they may not actually improve the ability to do real world tasks. The purpose of this research study is to determine if a medicine used to treat memory problems donepezil(Aricept) enhances the ability to remember steps of functional tasks and the actual ability to perform tasks relevant to real-life independence. Aricept is an FDA approved medication for the treatment of Alzheimer's disease. Aricept is an investigational drug for the purposes of this study, and is not approved for this purpose.

A Double-blind Study of E2020 (Donepezil Hydrochloride) in Patients With Dementia With Lewy Bodies (DLB) (Study E2020-J081-431) [Completed]
The purpose of this study is to evaluate the efficacy and safety of E2020 in patients with Dementia with Lewy Bodies (DLB).

Pharmacokinetic Comparisons of Two Donepezil Formulations [Completed]
To compare the relative bioavailability and pharmacokinetic characteristics of a newly developed donepezil formulation with a conventional formulation in healthy subjects with a

single dose, randomized, open-label, 2-sequence - 2period crossover study.

Bioequivalence Study for Donepezil Hydrochloride Tablets 10 mg Under Fed Condition [Completed]
This is an open label, balanced, randomized, two-treatment, two-period, two sequence, single dose, crossover, oral bioequivalence study.

Computerized Cognition Testing in Participants With Mild Alzheimer's Disease (AD) Treated With Donepezil (MK-0000-318) [Recruiting]
This study aims to determine whether the Cogstate testing battery can detect improvements in cognitive function in participants with mild AD. The primary hypothesis is that the standard deviation associated with the change from baseline in average One Card Learning (OCL) repeated measurements after 12 weeks of donepezil treatment is =<0. 1

more trials >>

Reports of Suspected Aricept (Donepezil) Side Effects

Syncope (31)Electrocardiogram QT Prolonged (26)Convulsion (25)Drug Interaction (24)Fall (22)Altered State of Consciousness (21)Bradycardia (20)Dementia (19)Vomiting (19)Loss of Consciousness (18)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 9 ratings/reviews, Aricept has an overall score of 4.67. The effectiveness score is 5.56 and the side effect score is 6.44. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Aricept review by care giver of 69 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Alzheimers
Dosage & duration:   5g for one month rising to 10g (dosage frequency: daily) for the period of 3 months total - and on-going
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Only moderate improvements noted on the 5g dosage. Improvements much more noticeable at 10g - or after 30 days of taking medication. Less confusion, more awareness in social surroundings, more outward and positive in attitude.
Side effects:   So far no negative noted
Comments:   Take one pill in the morning. Also vitamin supplements (Multi-vitamin, brain-booster vitamin, and homo-cysteine level reducer)

 

Aricept review by care giver of 80 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Alzheimer's disease
Dosage & duration:   10 mg taken once daily for the period of 6 months
Other conditions:   hernia, teeth problems
Other drugs taken:   Tamasapan
  
Reported Results
Benefits:   We could not identify any benefits at all. The behavior and memory problems remained unchanged or worsened over time. Anxiety continued to increase and the dementia progressed systematically. Disorientation continued to increase and the patient became more and more difficult to manage. It appeared that irritability increased and the patient became more agitated more easily.
Side effects:   There was some indication that there was at least some increase nausa as well as some infrequent but increased bouts of diarrhea. There were a few episodes of vomiting, but it might be attributed to other factors for this one side effect. There was definitely increased insomnia as well as loss of appetite, but it can not be definitively stated that the drug alone contributed to these although it did occur after the drug was begun.
Comments:   The patient was given a daily dose. After transfer to a care facility, the regimentation in taking the dose was firmly set in place. Staff medical personnel on site did not observe any benefits, and as a result, after about 6 months the prescription was terminated. During the time the drug was used, there was a patient review every other week to ascertain whether there seemed to be any improvement in the patient. Memory tests were administered and one-on-one interviews were executed by medical personnel. The results of the memory testing showed no net improvement nor was there any identifiable changes that might be considered positive. Ultimately her psychiatrist in consultation with the family decided that the drug did not seem to provide any net gain.

 

Aricept review by care giver of 67 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   short term memory loss
Dosage & duration:   5 mg taken once for the period of once
Other conditions:   severe head pain, feel like throwing up
Other drugs taken:   welbutrin
  
Reported Results
Benefits:   none, only took one pill and found that the side effects do not warrant continued use.
Side effects:   severe head pain, feel like throwing up, felt lousy for 12 hours after taking first pill.
Comments:   Will not take pill again. The side effects of loosing a nights sleep, having severe head pain, and feeling like throwing up will result in not taking another pill as this drug does not agree with patient.

See all Aricept reviews / ratings >>

Page last updated: 2015-08-28

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