ARICEPT SUMMARY
ARICEPT® (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase.
ARICEPT® is indicated for the treatment of mild to moderate dementia of the Alzheimer's type.
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NEWS HIGHLIGHTSMedia Articles Related to Aricept (Donepezil)
Generic Aricept Approved for Alzheimer's Dementia
Source: MedicineNet donepezil Specialty [2009.12.16]
Title: Generic Aricept Approved for Alzheimer's Dementia
Category: Health News
Created: 12/15/2009 4:10:00 PM
Last Editorial Review: 12/16/2009
ARICEPT (Donepezil) effective for severe Alzheimer's disease
Source: The Doctors Lounge - Neurology
Donepezil reverses some aspects of cognitive deterioration seen in severe Alzheimer's disease.
African-Americans And Hispanics More Likely To Have Alzheimer's Disease And Dementia Than Whites
Source: Mental Health News From Medical News Today [2010.03.09]
According to the Alzheimer's Association's® 2010 Alzheimer's Disease Facts and Figures, African-Americans are about two times more likely and Hispanics are about one and one-half times more likely than their white counterparts to have Alzheimer's and other dementias...
Alzheimer's Disease More Prevalent in Blacks, Hispanics
Source: MedPage Today Neurology [2010.03.09]
WASHINGTON (MedPage Today) -- African Americans and Hispanics are much more likely than whites to develop Alzheimer's disease and other dementias, according to new figures from the Alzheimer's Association.
Alzheimer's Disease Pictures Slideshow: A Caregiver's Guide
Source: MedicineNet Dementia Specialty [2010.02.17]
Title: Alzheimer's Disease Pictures Slideshow: A Caregiver's Guide
Category: Slideshows
Created: 2/16/2010 2:51:00 PM
Last Editorial Review: 2/17/2010
Published Studies Related to Aricept (Donepezil)
The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality. [2009.09]
CONCLUSION: Earlier NH admission of Australian compared to U.K. and U.S. subjects may be due to differences in health care, NH systems, availability, and affordability.
Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation. [2009.08.01]
STUDY OBJECTIVES: We investigated if donepezil, a long-acting orally administered cholinesterase inhibitor, would reduce episodic memory deficits associated with 24 h of sleep deprivation... CONCLUSIONS: Donepezil reduced decline in recognition performance in individuals vulnerable to the effects of sleep deprivation. Additionally, our findings demonstrate the utility of combined fMRI-behavior evaluation in psychopharmacological studies.
The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome. [2009.08]
The objective of our study was to assess the efficacy and safety of donepezil in young adults with Down syndrome (DS) but no evidence of Alzheimer disease (AD). A 12-week, randomized, double-blind, placebo-controlled study with a 12-week, open-label extension was conducted...
DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT. [2009.07.24]
BACKGROUND: Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has been widely prescribed, often in the later stages of AD...
Rates of Cognitive Change in Alzheimer Disease: Observations Across a Decade of Placebo-controlled Clinical Trials With Donepezil. [2009.06.25]
Treatment success in Alzheimer disease (AD) trials is generally based on benefits over placebo-treated controls...
Clinical Trials Related to Aricept (Donepezil)
Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer’s Disease [Completed]
Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to
moderate Alzheimer’s disease (AD). Aricept has been shown to improve the memory and thinking
abilities, activities of daily living and global function in patients. The purpose of the
study is to further investigate the effectiveness and safety of donepezil in patients with
severe Alzheimer’s disease.
Donepezil is thought to work in the brain by increasing the levels of an important brain
chemical called acetylcholine. This chemical helps a person’s memory to work better.
A Study of the Efficacy and Safety of Aricept in Patients With Severe Alzheimer's Disease Who Are Living in Skilled Nursing Homes [Completed]
The purpose of the study is to evaluate the efficacy and safety of Aricept in nursing home
patients with severe Alzheimer's disease.
Vaspect Study - An Open-Label Trial Of Donepezil in Vascular and Mixed Dementia [Completed]
To document effectiveness, safety, and tolerability of donepezil in patients with mixed
AD/VaD, and to further document the effectiveness, safety, and tolerability of donepezil in
patients with VaD. The effects of donepezil on executive functioning, behavior, general
cognition, ADLs and global functioning will be assessed.
EARTH 413: A Study of Aricept in Hispanic Patients With Mild to Moderate Alzheimer's Disease (AD) [Completed]
12-week, open-label study to evaluate the effectiveness and safety of donepezil hydrochloride
in Hispanic patients with mild to moderate Alzheimer's Disease (AD) in the U. S.
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17 [Not yet recruiting]
The purpose of this study is to determine the efficacy and safety of donepezil hydrochloride
(Aricept) in the treatment of the cognitive dysfunction shown by children with Down syndrome,
aged 11 to 17.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 7 ratings/reviews, Aricept has an overall score of 4.57. The effectiveness score is 5.43 and the side effect score is 6.29. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Aricept review by care giver of 69 year old male patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Alzheimers |
| Dosage & duration: | | 5g for one month rising to 10g (dosage frequency: daily) for the period of 3 months total - and on-going |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | Only moderate improvements noted on the 5g dosage.
Improvements much more noticeable at 10g - or after 30 days of taking medication. Less confusion, more awareness in social surroundings, more outward and positive in attitude. |
| Side effects: | | So far no negative noted |
| Comments: | | Take one pill in the morning.
Also vitamin supplements (Multi-vitamin, brain-booster vitamin, and homo-cysteine level reducer) |
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| | Aricept review by care giver of 80 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Alzheimer's disease |
| Dosage & duration: | | 10 mg taken once daily for the period of 6 months |
| Other conditions: | | hernia, teeth problems |
| Other drugs taken: | | Tamasapan | | |
Reported Results |
| Benefits: | | We could not identify any benefits at all. The behavior and memory problems remained unchanged or worsened over time. Anxiety continued to increase and the dementia progressed systematically. Disorientation continued to increase and the patient became more and more difficult to manage. It appeared that irritability increased and the patient became more agitated more easily. |
| Side effects: | | There was some indication that there was at least some increase nausa as well as some infrequent but increased bouts of diarrhea. There were a few episodes of vomiting, but it might be attributed to other factors for this one side effect. There was definitely increased insomnia as well as loss of appetite, but it can not be definitively stated that the drug alone contributed to these although it did occur after the drug was begun. |
| Comments: | | The patient was given a daily dose. After transfer to a care facility, the regimentation in taking the dose was firmly set in place. Staff medical personnel on site did not observe any benefits, and as a result, after about 6 months the prescription was terminated. During the time the drug was used, there was a patient review every other week to ascertain whether there seemed to be any improvement in the patient. Memory tests were administered and one-on-one interviews were executed by medical personnel. The results of the memory testing showed no net improvement nor was there any identifiable changes that might be considered positive. Ultimately her psychiatrist in consultation with the family decided that the drug did not seem to provide any net gain. |
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| | Aricept review by care giver of 77 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | alzheimer's/dementia |
| Dosage & duration: | | started at 5mg taken everyday for the period of 2 weeks |
| Other conditions: | | asthma, high blood pressure |
| Other drugs taken: | | drugs for the above conditions | | |
Reported Results |
| Benefits: | | none!!!! |
| Side effects: | | Within 1 week of taking this drug my Grandmother almost died. She started hearing voices talking to her telling her they were gona kill her & her family she stopped eating/going to the bathroom, she tried running away 2x. etc....She was admitted to the hospital and taken off of the aricept it has been 1 week in the hospital she would just lay there looking like she wasnt even alive still talking to the voices she heard.... & just yesterday she started coming back to reality/her normal self, i would NOT recommend this drug to anyone it almost killed her. |
| Comments: | | stated off with 5mg & gradually increased |
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Page last updated: 2010-03-09
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