ARICEPT® (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase.
ARICEPT® is indicated for the treatment of mild to moderate dementia of the Alzheimer's type.
Media Articles Related to Aricept (Donepezil)
ARICEPT (Donepezil) effective for severe Alzheimer's disease
Source: The Doctors Lounge - Neurology
Donepezil reverses some aspects of cognitive deterioration seen in severe Alzheimer's disease.
Link between sleep disturbance and amyloid in brain areas affected by Alzheimer's disease
Source: Seniors / Aging News From Medical News Today [2014.12.12]
Healthy, elderly research participants who report being more sleepy and less rested have higher levels of amyloid deposition in regions of the brain that are affected in Alzheimer's disease...
Researchers at Mainz University explore new approach for treating Alzheimer's disease
Source: Neurology / Neuroscience News From Medical News Today [2014.12.09]
It is estimated that about 35 million people worldwide currently suffer from dementia and it is expected that the number will increase to 135 million by the year 2050.
Breakdown in brain connection identified in early Alzheimer's disease
Source: MRI / PET / Ultrasound News From Medical News Today [2014.12.02]
Changes in brain connections visible on MRI could represent an imaging biomarker of Alzheimer's disease, according to a new study presented at the annual meeting of the Radiological Society of North...
Laying siege to beta-amyloid, the key protein in Alzheimer's disease
Source: Huntingtons Disease News From Medical News Today [2014.10.06]
The peptide - a small protein - beta-amyloid is strongly associated with Alzheimer's disease; however, researchers are still looking for unequivocal proof that this peptide is the causal agent of the...
Published Studies Related to Aricept (Donepezil)
Evaluation of an 8-item Severe Impairment Battery (SIB-8) vs. the full SIB in
moderate to severe Alzheimer's disease patients participating in a donepezil
explored the SIB-8 scale with respect to its validity and sensitivity... CONCLUSIONS: In this post hoc analysis, similar treatment effects were measured
Ventricular enlargement and its clinical correlates in the imaging cohort from
the ADCS MCI donepezil/vitamin E study. 
We analyzed the baseline and 3-year T1-weighted magnetic resonance imaging data
of 110 amnestic mild cognitive impairment (MCI) participants with minimal
hippocampal atrophy at baseline from the Alzheimer's Disease Cooperative Study
group MCI Donepezil/Vitamin E trial... Executive
decline was associated with right frontal and left temporal horn enlargement.
Donepezil and memantine for moderate-to-severe Alzheimer's disease. 
disease... CONCLUSIONS: In patients with moderate or severe Alzheimer's disease, continued
Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. [2011.11]
OBJECTIVES: To determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair... CONCLUSION: Participants randomized to donepezil had no significant improvement in delirium presence or severity but experienced more side effects. Overall, sufficient evidence was not found from this pilot study to warrant a definitive Phase III trial. (c) 2011, Copyright the Authors Journal compilation (c) 2011, The American Geriatrics Society.
Combination treatment in Alzheimer's disease: results of a randomized, controlled trial with cerebrolysin and donepezil. [2011.08]
Treatment with neurotrophic agents might enhance and/or prolong the effects of cholinesterase inhibitors (ChEIs) in Alzheimer's disease (AD)...
Clinical Trials Related to Aricept (Donepezil)
Aricept to Improve Functional Tasks in Vascular Dementia [Recruiting]
Medications for memory improvement are available but they may not actually improve the
ability to do real world tasks. The purpose of this research study is to determine if a
medicine used to treat memory problems donepezil(Aricept) enhances the ability to remember
steps of functional tasks and the actual ability to perform tasks relevant to real-life
independence. Aricept is an FDA approved medication for the treatment of Alzheimer's
disease. Aricept is an investigational drug for the purposes of this study, and is not
approved for this purpose.
Double-blind Study of E2020 in Patients With Dementia With Lewy Bodies - Phase II [Recruiting]
The purpose of this study is to evaluate the efficacy and safety of E2020 in patients with
Dementia with Lewy Bodies (DLB).
Efficacy and Safety of Aricept in the Treatment of Severe Alzheimerâs Disease [Completed]
Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to
moderate Alzheimer’s disease (AD). Aricept has been shown to improve the memory and thinking
abilities, activities of daily living and global function in patients. The purpose of the
study is to further investigate the effectiveness and safety of donepezil in patients with
severe Alzheimer’s disease.
Donepezil is thought to work in the brain by increasing the levels of an important brain
chemical called acetylcholine. This chemical helps a person’s memory to work better.
Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease [Recruiting]
The purpose of this study is to compare 23 mg donepezil sustained release to the currently
marketed formulation of 10 mg donepezil immediate release in patients with severe
Multi-centre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated With Parkinson's Disease [Not yet recruiting]
To demonstrate the superiority of donepezil over placebo in improving cognitive function,
neuropsychiatric burden and functional ability in people with Parkinson's disease and mild
dementia after 24 months of treatment.
To demonstrate the superiority of donepezil over placebo in improving patient and carer
quality of life and to establish the cost-effectiveness of donepezil.
Reports of Suspected Aricept (Donepezil) Side Effects
Electrocardiogram QT Prolonged (26),
Drug Interaction (24),
Altered State of Consciousness (21),
Loss of Consciousness (18), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 9 ratings/reviews, Aricept has an overall score of 4.67. The effectiveness score is 5.56 and the side effect score is 6.44. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Aricept review by care giver of 69 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Considerably Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Alzheimers|
|Dosage & duration:|| || 5g for one month rising to 10g (dosage frequency: daily) for the period of 3 months total - and on-going|
|Other conditions:|| || None|
|Other drugs taken:|| || None|
|Benefits:|| || Only moderate improvements noted on the 5g dosage.
Improvements much more noticeable at 10g - or after 30 days of taking medication. Less confusion, more awareness in social surroundings, more outward and positive in attitude. |
|Side effects:|| || So far no negative noted|
|Comments:|| || Take one pill in the morning.
Also vitamin supplements (Multi-vitamin, brain-booster vitamin, and homo-cysteine level reducer) |
Aricept review by care giver of 80 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || Alzheimer's disease|
|Dosage & duration:|| || 10 mg taken once daily for the period of 6 months|
|Other conditions:|| || hernia, teeth problems|
|Other drugs taken:|| || Tamasapan|
|Benefits:|| || We could not identify any benefits at all. The behavior and memory problems remained unchanged or worsened over time. Anxiety continued to increase and the dementia progressed systematically. Disorientation continued to increase and the patient became more and more difficult to manage. It appeared that irritability increased and the patient became more agitated more easily.|
|Side effects:|| || There was some indication that there was at least some increase nausa as well as some infrequent but increased bouts of diarrhea. There were a few episodes of vomiting, but it might be attributed to other factors for this one side effect. There was definitely increased insomnia as well as loss of appetite, but it can not be definitively stated that the drug alone contributed to these although it did occur after the drug was begun.|
|Comments:|| || The patient was given a daily dose. After transfer to a care facility, the regimentation in taking the dose was firmly set in place. Staff medical personnel on site did not observe any benefits, and as a result, after about 6 months the prescription was terminated. During the time the drug was used, there was a patient review every other week to ascertain whether there seemed to be any improvement in the patient. Memory tests were administered and one-on-one interviews were executed by medical personnel. The results of the memory testing showed no net improvement nor was there any identifiable changes that might be considered positive. Ultimately her psychiatrist in consultation with the family decided that the drug did not seem to provide any net gain.|
Aricept review by care giver of 67 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || short term memory loss|
|Dosage & duration:|| || 5 mg taken once for the period of once|
|Other conditions:|| || severe head pain, feel like throwing up|
|Other drugs taken:|| || welbutrin|
|Benefits:|| || none, only took one pill and found that the side effects do not warrant continued use.|
|Side effects:|| || severe head pain, feel like throwing up, felt lousy for 12 hours after taking first pill.|
|Comments:|| || Will not take pill again. The side effects of loosing a nights sleep, having severe head pain, and feeling like throwing up will result in not taking another pill as this drug does not agree with patient. |
Page last updated: 2014-12-12