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Arava (Leflunomide) - Published Studies

 
 



Arava Related Published Studies

Well-designed clinical trials related to Arava (Leflunomide)

Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients. [2011]

The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants. [2010.08.03]

Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome. [2010.08]

Comparison of combination therapies in the treatment of rheumatoid arthritis: leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha. [2010.05]

Pharmacokinetics and the antiplatelet effect of a new clopidogrel formulation, clopidogrel besylate, in healthy subjects. [2010.04]

[A comparison of leflunomide and subcutaneous methotrexate in the treatment of rheumatoid arthritis: an approximation based on the number needed to treat]. [2009.03]

Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis. [2007.07]

Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis. [2007.05.22]

Safety and efficacy of Leflunomide in primary Sjogren's syndrome - A phase II pilot study. [2007.01.12]

Randomised controlled trial of leflunomide in the treatment of immunoglobulin A nephropathy. [2006.04]

Combination of cyclosporine and leflunomide versus single therapy in severe rheumatoid arthritis. [2006.03]

Leflunomide improves psoriasis in patients with psoriatic arthritis: an in-depth analysis of data from the TOPAS study. [2006]

Double blind, randomised, placebo controlled study of leflunomide in the treatment of active ankylosing spondylitis. [2005.12]

Leflunomide or methotrexate for juvenile rheumatoid arthritis. [2005.04.21]

When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide? [2005.01]

Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis. [2004.09]

Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial. [2004.08]

Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo-controlled clinical trial. [2004.06]

Efficacy and safety of leflunomide 10 mg versus 20 mg once daily in patients with active rheumatoid arthritis: multinational double-blind, randomized trial. [2004.06]

Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus. [2004]

Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trial. [2003.08]

Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. [2003.08]

The efficacy and safety of leflunomide in patients with active rheumatoid arthritis: a five-year followup study. [2003.06]

Leflunomide for the treatment of rheumatoid arthritis: a systematic review and metaanalysis. [2003.06]

Cost effectiveness of adding leflunomide to a 5-year strategy of conventional disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. [2002.12.15]

Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial. [2002.11.05]

The effects of disease-modifying anti-rheumatic drugs on the Health Assessment Questionnaire score. Lessons from the leflunomide clinical trials database. [2002.08]

Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging. [2002.02]

Economic comparison of leflunomide and methotrexate in patients with rheumatoid arthritis: an evaluation based on a 1-year randomised controlled trial. [2002]

Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine. [2001.10]

Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. [2001.09]

Improved functional ability in patients with rheumatoid arthritis--longterm treatment with leflunomide versus sulfasalazine. European Leflunomide Study Group. [2001.09]

A randomized, controlled, single-blind trial of leflunomide in the treatment of rheumatoid arthritis. [2001]

Slowing of disease progression in rheumatoid arthritis patients during long-term treatment with leflunomide or sulfasalazine. [2001]

Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers. [2000.08]

Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. [2000.07]

A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. [2000.06]

Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group. [2000.03]

Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. [1999.11.22]

Function and health-related quality of life: results from a randomized controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group. [1999.09]

Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group. [1999.01.23]

Leflunomide versus methotrexate: a comparison of the European and American experience. [1999]

Leflunomide improves quality of life in rheumatoid arthritis. [1999]

Efficacy and safety of the new DMARD leflunomide: comparison to placebo and sulfasalazine in active rheumatoid arthritis. [1999]

Disease modification in rheumatoid arthritis with leflunomide. [1999]

Leflunomide and malononitrilamides. [1997.05]

Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis. [1996.11]

Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study. [1995.11]

Well-designed clinical trials possibly related to Arava (Leflunomide)

Teriflunomide, an inhibitor of dihydroorotate dehydrogenase for the potential oral treatment of multiple sclerosis. [2010.11]

Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 Study. [2010.04]

Teriflunomide, an inhibitor of dihydroorotate dehydrogenase for the potential oral treatment of multiple sclerosis. [2010]

Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 Study. [2010]

Providing patients with information about disease-modifying anti-rheumatic drugs: Individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction. [2009.06]

Review article: Progress of treatment in ANCA-associated vasculitis. [2009.02]

Providing patients with information about disease-modifying anti-rheumatic drugs: Individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction. [2008.09.15]

Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis. [2008]

Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score. [2007.10]

Increased disease activity is associated with a deteriorated lipid profile in patients with ankylosing spondylitis. [2006.11]

A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. [2006.03.28]

Advances in the therapy of Wegener's granulomatosis. [2006.01]

Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: randomized controlled trials overestimate treatment response and effectiveness. [2005.12]

Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies. [2005.10]

Lefunomide in combination therapy. [2004.06]

An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in a rheumatoid arthritis clinical trial. [2003.03]

Current treatment of juvenile rheumatoid arthritis. [2002.01]

Etanercept and methotrexate combination therapy. [1999.11]

Contrast enhanced Gd-DTPA magnetic resonance imaging in the evaluation of rheumatoid arthritis during a clinical trial with DMARDs. A prospective two-year follow-up study on hand joints in 31 patients. [1997.03]

Ticks (Acari: Ixodidae) infesting the Arabian camel (Camelus dromedarius) in the Sinai, Egypt with a note on the acaricidal efficacy of ivermectin. [1993.08]

Other research related to Arava (Leflunomide)

Effects of double filtration plasmapheresis, leflunomide, and methotrexate on inflammatory changes found through magnetic resonance imaging in early rheumatoid arthritis. [2012]

Leflunomide in monotherapy of rheumatoid arthritis: meta-analysis of randomized trials. [2012]

Leflunomide for cytomegalovirus: bench to bedside. [2012]

Leflunomide for cytomegalovirus: bench to bedside. [2011.10.09]

Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients. [2011.08]

Effective treatment of Kimura's disease with leflunomide in combination with glucocorticoids. [2011.06]

Leflunomide in renal transplantation. [2011.05]

Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses. [2011.05]

Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011? [2011.05]

Liver toxicity is rare in rheumatoid arthritis patients using combination therapy with leflunomide and methotrexate. [2011.04]

Interstitial lung diseases after leflunomide use in nephropathy: an analysis of reported cases in Chinese literature. [2011.04]

Soft tissue infections with atypical mycobacteria in two patients with inflammatory rheumatic diseases using TNF-inhibitors and/or leflunomide. [2011.03]

Leflunomide in Pakistani patients with rheumatoid arthritis: prospective study in daily rheumatology practice. [2011.02]

Anti-inflammatory and Anti-arthritic Effects of a Novel Leflunomide Analogue, UTL-5b (GBL-5b). [2011.01.01]

Identification and quantification of selected inflammatory genes modulated by leflunomide and prednisone treatment in early rheumatoid arthritis patients. [2011.01]

The effect of ESR1 and ESR2 gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide. [2011.01]

Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients. [2011]

Inhibition of respiratory syncytial virus in vitro and in vivo by the immunosuppressive agent leflunomide. [2011]

Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection. [2010.12.27]

Evaluation of efficacy of combination of methotrexate and hydroxychloroquine with leflunomide in active rheumatoid arthritis. [2010.12]

[Peripheral neuropathy caused by leflunomide. A case reported with a brief review]. [2010.09]

Leflunomide: a drug with a potential beyond rheumatology. [2010.09]

Utility of leflunomide in the treatment of complex cytomegalovirus syndromes. [2010.08.27]

Birth outcomes in women who have taken leflunomide during pregnancy. [2010.05]

Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment. [2010.04]

A rapid and simple high-performance liquid chromatography assay for the leflunomide metabolite, teriflunomide (A77 1726), in renal transplant recipients. [2010.03]

Rituximab and concomitant leflunomide for the treatment of rheumatoid arthritis. [2010.03]

Leflunomide: is a new oral agent in treatment of acute pancreatitis? [2010.03]

Efficacy of leflunomide for treatment of immune-mediated polyarthritis in dogs: 14 cases (2006-2008). [2010.02.01]

Methotrexate plus leflunomide for the treatment of relapsingWegener's granulomatosis. A retrospective uncontrolled study. [2010.01]

Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4+CD25+ regulatory T cells. [2010.01]

Microarray analysis of Leflunomide-induced limb malformations in CD-1 mice. [2010.01]

Influence of long-term leflunomide treatment on serum amyloid concentration in rheumatoid arthritis patients. [2010]

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