ARAVA SUMMARY
ARAVA® Tablets
(leflunomide)
10 mg, 20 mg, 100 mg
ARAVA® (leflunomide) is a pyrimidine synthesis inhibitor. The chemical name for leflunomide is N-(4'-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide.
ARAVA is indicated in adults for the treatment of active rheumatoid arthritis (RA):
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to reduce signs and symptoms
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to inhibit structural damage as evidenced by X-ray erosions and joint space narrowing
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to improve physical function.
(see CLINICAL STUDIES)
Aspirin, nonsteroidal anti-inflammatory agents and/or low dose corticosteroids may be continued during treatment with ARAVA (see PRECAUTIONS --
Drug Interactions
--
NSAIDs). The combined use of ARAVA with antimalarials, intramuscular or oral gold, D penicillamine, azathioprine, or methotrexate has not been adequately studied (see WARNINGS --
Immunosuppression Potential/Bone Marrow Suppression).
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