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Aralast ( Alpha 1-Antitrypsin) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

ARALAST drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

CONTRAINDICATIONS

Aralast™ is contraindicated in individuals with selective IgA deficiencies (IgA level less than 15 mg/dL) who have known antibody against IgA, since they may experience severe reactions, including anaphylaxis, to IgA which may be present.

REFERENCES

  1. Brantly M, Nukiwa T, Crystal RG. Molecular basis of alpha-1-antitrypsin deficiency. Am J Med 1988 (Suppl 6A);84:13-31.
  2. Data on file at Alpha Therapeutic Corporation.
  3. Crystal RG, Brantly ML, Hubbard RC, Curiel DT, et al. The alpha1-antitrypsin gene and its mutations: Clinical consequences and strategies for therapy. Chest 1989;95:196-208.
  4. Crystal RG. (alpha)1-Antitrypsin deficiency: pathogenesis and treatment. Hospital Practice 1991; Feb.15:81-94.
  5. Hutchison DCS. Natural history of alpha-1-protease inhibitor deficiency. Am J Med 1988;84(Suppl 6A):3-12.
  6. Hubbard RC, Crystal RG. Alpha-1-antitrypsin augmentation therapy for alpha-1-antitrypsin deficiency. Am J Med 1988;84(Suppl 6A):52-62.
  7. Ogushi F, Fells GA, Hubbard RC, et al. Z-Type (alpha)1-antitrypsin as an inhibitor of neutrophil elastase. J Clin Investigation 1987;80:1366-1374.
  8. Buist SA, Burrows B, Cohen A, et al. Guidelines for the approach to the patient with severe hereditary alpha-1-antitrypsin deficiency. Am Rev Respir Dis 1989;140:1494-1497.
  9. Stoller JK, Brantly M, Fleming LE, et al. Formation and current results of a patient-organized registry for (alpha)1-antitrypsin deficiency. Chest 2000; 118(3):843-848.

DATE OF REVISION: January 2003

Manufactured by:

alpha®

THERAPEUTIC CORPORATION

LOS ANGELES, CA 90032 USA

U.S. LICENSE NO. 744

Distributed by:

Baxter

Baxter Healthcare Corporation

One Baxter Way

Westlake Village, CA 91362 USA

© 2002 Alpha Therapeutic Corporation

Printed In USA

08-8127-01

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