AQUASOL A SUMMARY
AQUASOL A ® Parenteral (water-miscible vitamin A Palmitate) provides 50,000 USP Units of vitamin A per mL as retinol (C20H30O) in the form of vitamin A palmitate, a light yellow to amber oil.
Vitamin A injection is effective for the treatment of vitamin A deficiency.
The parenteral administration is indicated when the oral administration is not feasible as in anorexia, nausea, vomiting, pre- and postoperative conditions, or it is not available as in the Malabsorption Syndrome with accompanying steatorrhea.
Vitamin A treatment for deficiency states has been recognized as an especially effective and important therapy in the pediatric population.
Vitamin A supplementation for deficiency states in this population has been addressed by the Committee on Clinical Practice Issues of the American Society for Clinical Nutrition, by the American Society for Parenteral and Enteral Nutrition, and by the World Health Organization.
Published Studies Related to Aquasol A (Vitamin A Palmitate)
Efficacy of early neonatal supplementation with vitamin A to reduce mortality in
infancy in Haryana, India (Neovita): a randomised, double-blind,
placebo-controlled trial. 
with vitamin A to reduce mortality between supplementation and 6 months of age... INTERPRETATION: The findings of this study, done in a population in which vitamin
Effect of early neonatal vitamin A supplementation on mortality during infancy in
Ghana (Neovita): a randomised, double-blind, placebo-controlled trial. 
present the findings of the Neovita trial in Ghana... INTERPRETATION: The results of this trial do not support inclusion of newborn
Effect of neonatal vitamin A supplementation on mortality in infants in Tanzania
(Neovita): a randomised, double-blind, placebo-controlled trial. 
and 180 days (6 months)... INTERPRETATION: Neonatal vitamin A supplementation did not result in any
A double blind randomized controlled trial in neonates to determine the effect of
vitamin A supplementation on immune responses: The Gambia protocol. 
BACKGROUND: Vitamin A supplementation significantly reduces all-cause mortality
when given between 6-59 months of age, but has a null or detrimental effect when
given between 1-5 months... Combined these trials, in
addition to the existing trials, will inform policy.
The effect of vitamin A supplementation on disease progression, cytokine levels
and gene expression in multiple sclerotic patients: study protocol for a
randomized controlled trial. 
Multiple Sclerosis (MS) is a chronic inflammatory disease that leads to
degeneration of the brain and spinal tissue... According to
the difference between the epidemiological and clinical data on the relationship
between vitamin A and immune system regulation, this study of the first time
assesses Immune function as well as gene expression and progression of the
disease following administration of vitamin A supplement.
Clinical Trials Related to Aquasol A (Vitamin A Palmitate)
Efficacy of Newborn Vitamin A Supplementation in Improving Immune Function [Completed]
Vitamin A supplementation at birth may increase survival of infants through one year of age
by reducing mortality from infectious diseases, though current studies are not conclusive on
this point. The goal of our study is to determine if supplementation of newborn infants
with 50,000 IU of vitamin A improves aspects of immune function that may be impaired by
vitamin A deficiency. Our underlying assumption is that supplementation may thus decrease
risk of death by improving immune function and the ability to survive infections. This
project will be limited to the examination of the impact of vitamin A on immune function and
will not aim to determine the impact on morbidity or mortality, which would require larger
sample sizes. The hypotheses addressed by this study are as follows: Provision of vitamin A
supplements to newborns at risk of vitamin A deficiency will (1) improve functioning of the
thymus (the source of T lymphocytes, cells of the immune system that are important in
response to infection and immunization); (2) enhance T lymphocyte-mediated responses to
standard vaccines given at birth and early in infancy; and (3) improve gut barrier function
(i. e., ability to prevent bacterial infection across the epithelial barrier), relative to
provision of a placebo.
Vitamin A and Very Low Birthweight Babies (VitAL) [Completed]
Vitamin A is important for the development of healthy eyes and lungs. Very low birth weight
premature babies have low body stores of vitamin A and are prone to diseases of the eye and
lungs. Previous work has shown that intramuscular (IM) vitamin A reduces the number of
babies who require prolonged oxygen therapy, and may also reduce the number of babies
affected by retinopathy of prematurity (ROP)). There is also some evidence that the
conjunctiva shows signs of deficiency of vitamin A in premature infants, particularly those
who develop ROP. Our own work here in Glasgow suggests that, compared to babies born at
full term, premature babies' eyes are less sensitive to light and we believe that this may
reflect shortage of vitamin A in the eye. This study will examine the effects upon the eye
of giving extra intramuscular vitamin A to very low birth weight, premature infants. We
will also measure blood levels of vitamin A and calculate liver stores of this nutrient.
Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome [Not yet recruiting]
To research the effect of vitamin A to newborn respiratory distress syndrome by
intratracheal administration with surfactant.
Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit [Recruiting]
The purpose of this study is to evaluate the effect of post-partum maternal vitamin A
supplementation on breast milk bioactive compounds and immune status, growth and morbidity
of children in the first four months of life.
Determination of Changes in Total Body Stores of Vitamin A in Response to Orange Maize Consumption by Zambian Children [Completed]
Determination of liver stores of vitamin A will be determined before and after consumption
of high pro-vitamin A orange maize, compared to low provitamin A white maize.
Page last updated: 2015-08-10