Apresoline (Hydralazine Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse reactions with Apresoline are usually reversible when dosage is reduced. However, in some cases it may be necessary to discontinue the drug.

      The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency.

Common

Headache, anorexia, nausea, vomiting, diarrhea, palpitations, tachycardia, angina pectoris.

Less Frequent

Digestive: constipation, paralytic ileus.  

Cardiovascular : hypotension, paradoxical pressor response, edema.

Respiratory : dyspnea.

Neurologic : peripheral neuritis evidenced by paresthesia, numbness, and tingling, dizziness: tremors; muscle cramps; psychotic reactions characterized by depression, disorientation, or anxiety.

Genitourinary: difficulty in urination.  

Hematologic: blood dyscrasias, consisting of reduction in hemoglobin and red cell count, leukopenia, agranulocytosis, purpura, lymphadenopathy; splenomegaly.

Hypersensitive Reactions: rash, urticaria, pruritus, fever, chills, arthralgia, eosinophilia, and, rarely, hepatitis.

Other: nasal congestion, flushing, lacrimation, conjunctivitis .

REPORTS OF SUSPECTED APRESOLINE SIDE EFFECTS / ADVERSE REACTIONS

Possible Apresoline side effects / adverse reactions in 60 year old male

Reported by a consumer/non-health professional from Brazil on 2011-10-03

Patient: 60 year old male

Reactions: Movement Disorder, Wrong Technique in Drug Usage Process, Lung Disorder, Urinary Tract Infection, Cerebrovascular Accident, Prostatic Disorder

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Diovan
    Dosage: 1 df, bid
    Indication: Hypertension

Apresoline
    Dosage: 50 mg (half tablets 3 times/day)

Apresoline
    Dosage: 25 mg, tid
    Indication: Hypertension

Possible Apresoline side effects / adverse reactions in 35 year old female

Reported by a individual with unspecified qualification from Japan on 2011-10-06

Patient: 35 year old female weighing 64.0 kg (140.8 pounds)

Reactions: Phaeochromocytoma, Drug Ineffective, Maternal Exposure During Pregnancy, Tachycardia, Loss of Consciousness, Hypertensive Crisis, Circulatory Collapse, Ventricular Fibrillation

Adverse event resulted in: death

Suspect drug(s):
Labetalol HCL
    Dosage: 35 mg, unk
    Indication: Hypertensive Crisis

Apresoline
    Dosage: 10 mg, unk

Apresoline
    Dosage: 5 mg, unk

Nicardipine HCL
    Dosage: 1 mg, unk
    Indication: Hypertension

Nicardipine HCL
    Dosage: 2 mg, unk

Other drugs received by patient: Dopamine HCL

Possible Apresoline side effects / adverse reactions in 60 year old male

Reported by a individual with unspecified qualification from United Kingdom on 2011-10-28

Patient: 60 year old male

Reactions: Movement Disorder, Wrong Technique in Drug Usage Process, Pneumonia, Urinary Tract Infection, Cerebrovascular Accident, Prostatic Disorder, Nosocomial Infection, Lung Disorder, Urinary Tract Infection Bacterial, Prostatomegaly, Urinary Retention, Infarction

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Apresoline
    Dosage: 25 mg, tid
    Indication: Hypertension

Apresoline
    Dosage: 50 mg (half tablets 3 times/day)

Diovan
    Dosage: 1 df, bid
    Indication: Hypertension

Other drugs received by patient: Amlodipine; Seroquel; Clonidine Hydrochloride; Enalapril Maleate; Aspirin; Lipitor; Macrodantin