Media Articles Related to Apokyn (Apomorphine)
Study links Parkinson's disease to gut bacteria
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2014.12.12]
A new study finds that people with Parkinson's disease have a different mix of gut bacteria to healthy counterparts, suggesting this might be useful for diagnosis or treatment.
Parkinson's disease-related weight and eating habits
Source: Depression News From Medical News Today [2014.11.25]
Patients affected by Parkinson's disease often show marked changes in body weight: they may gain or lose a lot of weight depending on the stage of the disease, or they may put on up to ten kilos...
'Medium' daily exercise tied to lower risk of Parkinson's disease
Source: Sports Medicine / Fitness News From Medical News Today [2014.11.19]
A new study finds medium amounts of daily physical exercise from doing chores, commuting and leisure pursuits is associated with a reduced risk of developing Parkinson's disease.
The inhibition of a mitochondrial fission protein shows promise as a potential treatment for Parkinson's disease
Source: Huntingtons Disease News From Medical News Today [2014.11.08]
A study led by a researcher from Plymouth University in the UK, has discovered that the inhibition of a particular mitochondrial fission protein could hold the key to potential treatment for...
Source: MedicineNet levodopa-carbidopa Specialty [2013.12.04]
Title: Parkinson's Disease
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 12/4/2013 12:00:00 AM
Published Studies Related to Apokyn (Apomorphine)
Randomized, placebo-controlled trial of trimethobenzamide to control nausea and
vomiting during initiation and continued treatment with subcutaneous apomorphine
may not be needed, although this has not been systematically studied... CONCLUSION: Our data suggest that trimethobenzamide helps reduce nausea/vomiting
Sustained efficacy of apomorphine in Japanese patients with advanced Parkinson's
apomorphine rescue treatment... CONCLUSIONS: Our results indicate that a 3-month use of intermittent apomorphine
Apomorphine effect on pain threshold in Parkinson's disease: a clinical and positron emission tomography study. [2011.01]
Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain-induced cerebral activity in 25 patients with PD...
Comparison of apomorphine and levodopa infusions in four patients with Parkinson's disease with symptom fluctuations. [2009.05]
BACKGROUND: Motor fluctuations in patients with advanced Parkinson's disease may be successfully treated with subcutaneous apomorphine infusion or intraduodenal levodopa/carbidopa infusion. No comparative trials of these two alternatives were performed. AIMS OF THE STUDY: We present a subanalysis from a randomized crossover clinical trial where levodopa infusion as monotherapy was compared with any other combination of pharmacotherapy in fluctuating patients. Four patients used apomorphine infusion and oral levodopa in the comparator arm. The results of these four patients are presented in detail... CONCLUSIONS: Monotherapy with duodenal infusion of levodopa was more efficacious and brought greater QoL than combination therapy with apomorphine infusion in these fluctuating patients.
Apomorphine nodules in Parkinson's disease: best practice considerations. [2008.10]
Apomorphine hydrochloride infusion therapy is used by approximately 1000 people with advanced Parkinson's disease in the UK (Britannia Pharmaceuticals Ltd, 2008).
Clinical Trials Related to Apokyn (Apomorphine)
Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT) [Recruiting]
Comparison of Continuous and Pulsatile Apomorphine in Parkinson's Disease [Recruiting]
The purpose of this study is to compare the effects of apomorphine, given by two different
methods, to determine how best to manage dyskinesias.
Safety/Efficacy of Tigan´┐Ż to Control Nausea/Vomiting Experienced During Apokyn´┐Ż Initiation and Treatment [Recruiting]
The purposes of the study are to determine:
i. To assess the efficacy of Tigan« (trimethobenzamide) in preventing nausea and vomiting
when initiating therapy with Apokyn« (apomorphine)
ii. To determine the optimal duration for continuation of Tigan« following initiation of
iii. To assess the safety of Tigan« in combination with Apokyn«
iv. To characterize the pharmacokinetic (PK) profile of apomorphine in subjects treated
concomitantly with and without Tigan┬«
Continued Efficacy and Safety of Apomorphine in Patients With Late-Stage Parkinsons Disease [Completed]
Apomorphine Effect on Nociceptive Perception in Parkinson's: a Clinical and Imaging Study [Completed]
Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations.
We suppose that painful symptoms could be related to the neurotransmitter deficit of PD. So,
we would like to evaluate the involvement of dopaminergic system in nociceptive processing in
PD patients. The objectives of this study is to assess and to compare the effect of a
dopamine agonist administration on the nociceptive threshold and on the cerebral activity
using positrons emission tomography (PET scan) in two groups of PD patients (in 16 painful PD
patients and in 16 pain free PD patients). We hypothesise that dopamine agonist could
normalise nociceptive threshold and cerebral activity which were both abnormal in PD
patients. Moreover, we think that painful PD patients could be more improved by dopamine
agonist than pain free PD patients.
Reports of Suspected Apokyn (Apomorphine) Side Effects
Condition Aggravated (2),
Atrial Fibrillation (2),
Malabsorption From Injection Site (2), more >>