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Aplisol (Tuberculin) - Drug Interactions, Contraindications, Overdosage, etc



In patients who are receiving corticosteroids or immunosuppressive agents, reactivity to the test may be depressed or suppressed. This reduced reactivity may be present for as long as 5-6 weeks after discontinuation of therapy (see PRECAUTIONS -- General). 9

The reactivity to PPD may be temporarily depressed by certain live virus vaccines. Therefore, if a tuberculin test is to be performed, it should be administered either before or simultaneously with the use of oral polio and/or injection of measles, mumps and rubella vaccines in combined form or as separate antigens, or testing should be postponed for 4-6 weeks. 10


Aplisol is contraindicated in patients with known hypersensitivity or allergy to Aplisol or any of its components. Aplisol should not be administered to persons who have previously experienced a severe reaction (e.g., vesiculation, ulceration, or necrosis) because of the severity of reactions that may occur at the test site.


1 Seibert, F.B.: Am Rev Tuberc, 30:713, 1934

2 Seibert, F.B., and Glenn, J.T.: Am Rev Tuberc, 44:9, 1941

3 MMWR, 1995:44 RR-11

4 MMWR, 1996:45 RR-4

5 Huebner RE, Shein MF, Bass JB, The Tuberculin Skin Test, Clin Infect Dis, 1993;17:968-75

6 AHFS Drug Information, 1997, 36:84 pp 1962-1968

7 American Thoracic Society: Diagnostic Standards and classification of tuberculosis, 1990 Am Rev Respir Dis, 142:725-735

8 Am Rev Respir Dis, 1985;886

9 Brickman HF et.Al., The Timing of Tuberculin Tests in Relation to Immunization with Live Viral Vaccines, Pediatrics ; 1975;55:392

10 Red Book Report of the Committee on Infectious Disease, (1994)

11 Landi S, Held HR, Stability of a dilute solution of tuberculin purified derivative at extreme temperatures, J Biol Stand, 1981; 9:195

12 Diagnosis of TB Infection and TB Disease, Centers For Disease Control and Prevention(CDC), March 21, 1996, Doc# 2250102

13 Sewell E.M., O'Hare, D., and Kendig, E.L., Jr.: The Tuberculin Test, Pediatrics, Vol.54, No. 5, Nov.1974.

14 Advisory Committee of Elimination of Tuberculosis (ACET/CDC: Prevention and control of tuberculosis in facilities providing long-term care to the elderly, 1990. MMWR 39(10): 7-13,15.

15 ACET(CDC): The use of preventative therapy for tuberculosis infection in the United States, 1990. MMWR 39(8):9-12.

16 ACET(CDC): Screening for tuberculosis and tuberculosis infection in high risk populations. Recommendations of the ACET, 1990, MMWR 39(8):1-7.

Rx only.

Prescribing Information as of May 2002



Manufactured by:

Parkedale Pharmaceuticals, Inc.

Rochester, MI 48307


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