WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS AND NEUROPSYCHIATRIC REACTIONS IN PATIENTS TAKING BUPROPION FOR SMOKING CESSATION
SUICIDALITY AND ANTIDEPRESSANT DRUGS
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of APLENZIN or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber [see Warnings and Precautions
NEUROPSYCHIATRIC REACTIONS IN PATIENTS TAKING BUPROPION FOR SMOKING CESSATION
Serious neuropsychiatric reactions have occurred in patients taking bupropion for smoking cessation [see Warnings and Precautions
]. The majority of these reactions occurred during bupropion treatment, but some occurred in the context of discontinuing treatment. In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking bupropion who continued to smoke. Although APLENZIN is not approved for smoking cessation, observe all patients for neuropsychiatric reactions. Instruct the patient to contact a healthcare provider if such reactions occur [see Warnings and Precautions
Aplenzin (bupropion hydrobromide), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents.
AplenzinÂ™ (bupropion hydrobromide extended-release tablets) is indicated for the treatment of major depressive disorder.
Published Studies Related to Aplenzin (Bupropion)
Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy
3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a popular recreational
drug. The aim of the present study was to explore the role of dopamine in the
psychotropic effects of MDMA using bupropion to inhibit the dopamine and
norepinephrine transporters through which MDMA releases dopamine and
norepinephrine by investigating.
Bupropion in adults with Attention-Deficit/Hyperactivity Disorder: a randomized,
double-blind study. 
Attention-Deficit/Hyperactivity Disorder is one of the most common mental
disorders in childhood, and it continues to adulthood without proper treatment. Stimulants have been used in the treatment of Attention-Deficit/Hyperactivity
Disorder (ADHD) for many years, and the efficacy of methylphenidate in the
treatment of adults with ADHD has been proven to be acceptable according to
SSRI versus bupropion effects on symptom clusters in suicidal depression: post
hoc analysis of a randomized clinical trial. 
CONCLUSIONS: The results require replication but suggest a pathway by which
Bupropion for smoking cessation in patients hospitalized with acute myocardial
infarction: a randomized, placebo-controlled trial. 
patients with acute myocardial infarction (AMI)... CONCLUSIONS: Two-thirds of patients return to smoking by 12 months after AMI.
The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence. 
cognitive-behavioral mood management therapy... CONCLUSIONS: VNTR by treatment interaction differences between these and previous
Clinical Trials Related to Aplenzin (Bupropion)
Bupropion Hydrochloride 300 mg Extended Release Tablets Under Fasting Conditions [Recruiting]
The objective of this study is to evaluate the comparative bioavailability between bupropion
hydrochloride 300 mg extended release tablets (Teva Pharmaceuticals USA) and Wellbutrin XL®
300 mg extended release tablets (Biovail Pharmaceuticals, Inc.) at steady-state in patients
under fasting conditions.
Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial [Recruiting]
Patients who continue to smoke after a heart attack have a 35% increased risk of a recurrent
event or death compared with those who quit. Many patients attempt to stop smoking after a
heart attack, but relapse rates approach 66%. A variety of smoking cessation aids have been
shown to be effective for the general population. However, bupropion is the only
non-nicotine replacement therapy shown to improve abstinence rates in healthy young smokers.
Furthermore, nicotine replacement therapies (NRTs) are contraindicated in the immediate
period following a heart attack because of the undesirable effects of nicotine. Although
bupropion has been successfully used to reduce smoking rates in healthy young populations,
its efficacy and safety in the setting of patients recovering from an ACS is unknown. These
patients, if they continue to smoke, are at exceptionally high risk for recurrent cardiac
events. If bupropion is effective in this population, it will have a major impact on
secondary prevention of recurrent clinical events in patients who suffer a heart attack.
The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior [Recruiting]
The purpose of this study is to examine how smoking cessation medications (varenicline,
bupropion) affect the ability to resist smoking and also subsequent ad-lib smoking in
non-treatment seeking daily smokers.
Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype [Recruiting]
Nicotine replacement therapy (NRT) is a well-tolerated and efficacious smoking cessation
treatment, and yet many smokers fail to quit using NRT. Many of these smokers may benefit
from prescription treatment alternatives, including Zyban or Chantix. In this study, the
investigators propose to develop and evaluate a stepped-care treatment algorithm that would
evaluate whether smokers who receive treatment with NRT should be supplemented with Zyban or
switched to Chantix only based on: 1) their initial response to NRT; and 2) individual
genetic factors found to predict smoking cessation in other studies evaluating these
treatments. This study is a continuation of our previous studies showing that abstinence
rates can be increased by starting nicotine patch therapy two weeks before the quit date.
The investigators will provide pre-cessation NRT to all participants initially. Those who
do not show a favorable response on early indicators of success (e. g., smoking in the first
week after the target quit-smoking date) will receive "rescue" treatment by having their NRT
treatment supplemented with Zyban , by being switched to treatment with Chantix or will
remain on NRT (control).
The investigators hypothesize that "Rescue" treatment with Zyban in combination with NRT or
Chantix will increase success rates over leaving subjects on NRT when they are NRT
insufficient responders, i. e. they have shown an unfavorable response to NRT in the first
week pre-quit or the first week post-quit.
Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 2: Do Varenicline (Chantix) and Bupropion (Zyban) Change Alcohol Drinking? [Recruiting]
The purpose of this study is to examine the effect of smoking cessation medications on
Following 7 days of medication pre-treatment to achieve steady state levels, participants
complete a laboratory session assessing alcohol self-administration behavior and a cue
reactivity session assessing their reactivity to alcohol-related cues. Subjects are
maintained on study medication for 4 weeks after the laboratory session.
The study is subdivided into three studies based on subject population.
Study 1A enrolls heavy drinking smokers (tested under nicotine deprivation). Study 1B
enrolls heavy drinking smokers (not tested under nicotine deprivation), non-daily smokers,
and nonsmokers. Study 1C enrolls smokers (not tested under nicotine deprivation) and
nonsmokers who meet criteria for alcohol use disorders.
In Study 1A, volunteers are administered either varenicline (Chantix), bupropion (Zyban), or
placebo. In Studies 1B and 1C, volunteers are administered either varenicline (Chantix) or
Page last updated: 2015-08-10