ANUSOL HC SUMMARY
Anusol-HC® 2.5%
(Hydrocortisone Cream, USP)
The topical corticosteroids constitute a class of primarily synthetic steroids used as antiinflammatory and antipruritic agents. Anusol-HC 2.5% (Hydrocortisone Cream, USP) is a topical corticosteroid with hydrocortisone 2.5% (active ingredient) in a water-washable cream containing the following inactive ingredients: benzyl alcohol, petrolatum, stearyl alcohol, propylene glycol, isopropyl myristate, polyoxyl 40 stearate, carbomer 934, sodium lauryl sulfate, edetate disodium, sodium hydroxide to adjust the pH, and purified water.
Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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NEWS HIGHLIGHTS
Published Studies Related to Anusol HC (Hydrocortisone Topical)
Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. [2008.11]
BACKGROUND: Vitiligo is a pigmentary disorder which may have disfiguring consequences. Its treatment remains a challenge. OBJECTIVES: We designed a parallel-group randomized controlled trial to compare the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in patients with vitiligo unresponsive to previous treatment with topical steroids or narrow-band ultraviolet (UV) B phototherapy... CONCLUSIONS: Recalcitrant vitiligo of the face and neck may benefit from the combination of excimer laser phototherapy with topical hydrocortisone 17-butyrate cream.
Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. [2008.08.19]
Background Vitiligo is a pigmentary disorder which may have disfiguring consequences... Conclusions Recalcitrant vitiligo of the face and neck may benefit from the combination of excimer laser phototherapy with topical hydrocortisone 17-butyrate cream.
1% Hydrocortisone ointment is an effective treatment of pruritus ani: a pilot randomized controlled crossover trial. [2007.12]
BACKGROUND: Pruritus ani (PA) is a common condition which is difficult to treat in the absence of obvious predisposing factors. There is paucity of evidence-based guidelines on the treatment of this condition. We examined whether 1% hydrocortisone ointment is an effective treatment for PA... CONCLUSION: A short course of mild steroid ointment is an effective treatment for PA.
The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. [2007.02]
BACKGROUND: While many studies have demonstrated the efficacy and safety of tacrolimus ointment in the treatment of atopic dermatitis (AD), only a few have investigated the effects of tacrolimus on inflammatory cells and their cytokine gene expression in patients with AD. OBJECTIVES: To characterize further the immunophenotype of infiltrating cells and the production of certain cytokines before and after treatment with topical tacrolimus and hydrocortisone butyrate... CONCLUSIONS: Tacrolimus not only inhibits T-lymphocyte proliferation and cytokine production, but also plays an important role in the IL-12-induced shift from a T-helper (Th) 2 to a Th1 cytokine profile that characterizes the development of chronic AD. Tacrolimus also demonstrates wider pharmacodynamic effects than hydrocortisone.
Expression of adhesion molecules in atopic dermatitis is reduced by tacrolimus, but not by hydrocortisone butyrate: a randomized immunohistochemical study. [2006.11]
Topical tacrolimus represents an effective and well-tolerated treatment for atopic dermatitis (AD). Its known effects include reduced production of proinflammatory cytokines and reduced chemokine gradient...
Clinical Trials Related to Anusol HC (Hydrocortisone Topical)
Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis [Recruiting]
Efficacy Study of Low-Dose Hydrocortisone Treatment for Fibromyalgia [Completed]
This study is based on clinical findings that some patients with fibromyalgia have a tendency
towards lower levels of the stress hormone cortisol. The hypothesis to be tested in this
study is that the administration of a very low-dose of cortisol which has no side effects
corrects this deficiency and results in an improvement of symptoms
Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure [Completed]
Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects
of physiological cortisol substitution and withdrawal is studied and related to the clinical
syndrome of adrenal insufficiency.
Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants [Recruiting]
The purpose of this study is to investigate the early use of hydrocortisone in hypotensive
very low birth weight infants.
Based on the observations that:
- hypotension is a common problem in very low birthweight infants and is associated with
brain injury and poor neurological outcomes;
- some infants are refractory to standard treatment (volume expansion and vasopressors),
which is not exempt of adverse effects;
- relative adrenal insufficiency has been described in this population; we hypothesize
that hydrocortisone is effective in the treatment of hypotension in this population and
reduce the need for vasopressors.
Hydrocortisone in Patients of Out-of-Hospital Cardiac Arrest [Recruiting]
Out-of-hospital cardiac arrest (OHCA) is an important issue for the emergency physicians and
co-workers. How to improve the return of spontaneous circulation (ROSC) rate and prognosis
of these patients challenges the emergency team. When encounters stress, the hypothalamus of
human releases corticotropin releasing hormone, which in turn stimulates the pituitary gland
to release ACTH. Then ACTH acts on the adrenal gland to release glucocorticoid to against
stress. Foley PJ et al found the dogs with bilateral adrenalectomy had lower ROSC rate
during resuscitation than those without surgery[1]. Karl H. Linder et al showed OHCA
patients had high serum vasopressin and ACTH level but low serum cortisol level. Besides,
the serum cortisol level had a negative correlation with collapse duration (no CPR
duration)[2]. Studies also revealed the successfully resuscitated patients had higher serum
ACTH and cortisol level than non-resuscitated ones[2,3]. In addition, the serum cortisol
level was found to be correlated with short term survival rate and hemodynamic status in
resuscitated OHCA patients[3]. Animal study also showed mice receiving higher dosage of
hydrocortisone had higher ROSC rate and lower epinephrine requirement than those receiving
lower dosage of hydrocortisone or normal saline.
1. Foley PJ, Tacker WA, Wortsman J, Frank S, Cryer PE.;“ Plasma catecholamine and serum
cortisol responses to experimental cardiac arrest in dogs.”Am J Physiol 1987;253: E283-9
2. Lindner KH, Strohmenger HU, Ensinger H, Hetzel WD, Ahnefeld FW, Georgieff M.;” Stress
hormone response during and after cardiopulmonary resuscitation.”Anesthesiology
1992;77: 662-8
3. Schultz CH, Rivers EP, Feldkamp CS, Goad EG, Smithline HA, Martin GB, Fath JJ, Wortsman
J, Nowak RM.;“A characterization of hypothalamic-pituitary-adrenal axis function during
and after human cardiac arrest.”Crit Care Med 1993;21: 1339-47
4. Smithline H, Rivers E, Appleton T, Nowak R.;”Corticosteroid supplementation during
cardiac arrest in rats.”Resuscitation 1993;25: 257-64
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