ANUSOL HC SUMMARY
The topical corticosteroids constitute a class of primarily synthetic steroids used as antiinflammatory and antipruritic agents. Anusol-HC 2.5% (Hydrocortisone Cream, USP) is a topical corticosteroid with hydrocortisone 2.5% (active ingredient) in a water-washable cream containing the following inactive ingredients: benzyl alcohol, petrolatum, stearyl alcohol, propylene glycol, isopropyl myristate, polyoxyl 40 stearate, carbomer 934, sodium lauryl sulfate, edetate disodium, sodium hydroxide to adjust the pH, and purified water.
Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Published Studies Related to Anusol HC (Hydrocortisone Topical)
Clobetasol propionate, 0.05%, vs hydrocortisone, 1%, for alopecia areata in
children: a randomized clinical trial. 
IMPORTANCE: Alopecia areata is an idiopathic cause of hair loss with limited
therapeutic repertoire. OBJECTIVE: To compare the efficacy and safety of a high- vs low-potency topical
corticosteroid in pediatric patients...
Randomized, double-blind, split-side, comparison study of moisturizer containing
licochalcone A and 1% hydrocortisone in the treatment of childhood atopic
CONCLUSION: Lic A had a similar result in terms of SCORAD compared to 1%
Randomized, double-blind, split-side comparison study of moisturizer containing
licochalcone vs. 1% hydrocortisone in the treatment of infantile seborrhoeic
hydrocortisone for the treatment of ISD... CONCLUSION: Moisturizer containing 0.025% licochalcone had higher cure rate
Single-blind, randomized controlled trial evaluating the treatment of facial seborrheic dermatitis with hydrocortisone 1% ointment compared with tacrolimus 0.1% ointment in adults. [2011.11.17]
BACKGROUND: Tacrolimus is a topical calcineurin inhibitor with immunomodulatory, anti-inflammatory, and fungicidal properties that may be beneficial in the treatment of facial seborrheic dermatitis. OBJECTIVES: We sought to compare the efficacy and safety of tacrolimus with standard corticosteroid treatment in adults with facial seborrheic dermatitis in a phase II, single-blind, randomized controlled trial... CONCLUSION: Tacrolimus 0.1% ointment required significantly fewer applications compared with hydrocortisone 1% ointment to achieve a comparable clinical response in adults with facial seborrheic dermatitis. Tacrolimus was generally well tolerated. Copyright (c) 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Comparable efficacy of a topical 0.0584% hydrocortisone aceponate spray and oral ciclosporin in treating canine atopic dermatitis. [2011.07.01]
This study compared the efficacy of a 0.0584% hydrocortisone aceponate (HCA) spray (Cortavance((R)) ; Virbac SA) and ciclosporin (Atopica((R)) ; Novartis Animal Health) in canine atopic dermatitis in a single-blind randomized controlled trial. Dogs received HCA (two sprays/100 cm(2) ; n = 24) or ciclosporin (5 mg/kg; n = 21)...
Clinical Trials Related to Anusol HC (Hydrocortisone Topical)
The Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Replacement [Completed]
One postoperative complication following unilateral or bilateral total knee replacement is
thrombosis (blood clot formation). In this prospective, double-blinded randomized controlled
clinical trial, researchers are investigating the effect of steroids on biochemical markers
of thrombosis. Furthermore, elevated cellular markers of thrombosis (specifically IL-6) have
been linked to postoperative depression following total knee replacement surgery. Hence the
investigators are also checking if use of hydrocortisone, a steroid, may help reduce the
incidence of postoperative depression.
Other studies have shown that surgery causes some reaction in the body that is consistent
with inflammation. When the inflammation is extensive, it may affect different parts of the
body. It may also lead to clotting disorders and result in blood clots. In a previous study
by this principal investigator (see reference 22, "Use of low-dose steroids in decreasing
cytokine release during bilateral total knee replacement"), hydrocortisone was administered
over 24 hours following surgery to patients who underwent bilateral total knee replacements.
The investigator found lower levels of cellular markers consistent with inflammation
(specifically the protein, IL-6). Steroid use also showed additional benefits, such as
decreased pain and better range of motion at the knee.
In this study, investigators recruit patients undergoing total knee replacement surgery.
Patients are randomized to receive three 100 mg doses of hydrocortisone or three doses of a
saline placebo. In addition to analyzing patients' blood samples for hydrocortisone's effect
on clotting factors (i. e. IL-6), investigators record patients' pain scores and patients'
oral analgesic use. To assess patients' well-being, patients are contacted one month and 3
months following their surgeries and administered the Patient Health Questionnaire (see
reference 23, "The PHQ-9: validity of a brief depression severity measure.")
Page last updated: 2014-11-30