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Antizol (Fomepizole) - Published Studies


Antizol Related Published Studies

Well-designed clinical trials related to Antizol (Fomepizole)

Fomepizole as an antidote for ethylene glycol poisoning. [2002.06]

Well-designed clinical trials possibly related to Antizol (Fomepizole)

Evaluation of 4-methylpyrazole as a potential therapeutic dark adaptation inhibitor. [2007.10]

Increased plasma fatty acid ethyl ester levels following inhibition of oxidative metabolism of ethanol by 4-methylpyrazole treatment in human subjects. [2006.07]

Testosterone increases in men after a low dose of alcohol. [2003.04]

Ethanol, acetaldehyde, acetate, and lactate levels after alcohol intake in white men and women: effect of 4-methylpyrazole. [2002.02]

Effect of 4-methylpyrazole on endogenous plasma ethanol and methanol levels in humans. [2001.04]

Kinetic interactions between 4-methylpyrazole and ethanol in healthy humans. [1996.08]

Comparison of ethanol and 4-methylpyrazole as treatments for ethylene glycol intoxication in cats. [1994.12]

Non-linear kinetics of 4-methylpyrazole in healthy human subjects. [1989]

4-Methylpyrazole and the cutaneous vascular sensitivity to alcohol in Orientals. [1988.08]

4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses. [1988.08]

Other research related to Antizol (Fomepizole)

Medication errors associated with the use of ethanol and fomepizole as antidotes for methanol and ethylene glycol poisoning. [2011.06]

Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole. [2010.08]

Fomepizole fails to prevent progression of acidosis in 2-butoxyethanol and ethanol coingestion. [2010.07]

Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. [2010.06]

Protective effects of fomepizole on 2-chloroethanol toxicity. [2010.06]

Massive ethylene glycol ingestion treated with fomepizole alone-a viable therapeutic option. [2010.06]

Safety and efficacy of high-dose fomepizole compared with ethanol as therapy for ethylene glycol intoxication in cats. [2010.04.01]

Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. [2009.04]

Fomepizole: a critical assessment of current dosing recommendations. [2009.02]

Bradycardia and hypotension associated with fomepizole infusion during hemodialysis. [2008.07]

Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning. [2008.07]

Oral administration of fomepizole produces similar blood levels as identical intravenous dose. [2008.03]

The management of severe toxic alcohol ingestions at a tertiary care center after the introduction of fomepizole. [2007.09]

Ethylene glycol ingestion treated only with fomepizole. [2007.09]

Compliance with poison center fomepizole recommendations is suboptimal in cases of toxic alcohol poisoning. [2006.11]

Fomepizole may change indication for hemodialysis in methanol poisoning: prospective study in seven cases. [2005.09]

Fomepizole as a therapeutic strategy in paediatric methanol poisoning. A case report and review of the literature. [2005.03]

Methanol and formate kinetics during treatment with fomepizole. [2005]

Fomepizole alone for severe infant ethylene glycol poisoning. [2004.09]

Inhalational methanol toxicity in pregnancy treated twice with fomepizole. [2003.02]

Antidote review: fomepizole for methanol poisoning. [2003.01]

Fomepizole therapy for reversal of visual impairment after methanol poisoning: a case documented by visual evoked potentials investigation. [2002.12]

[Severe ethylene glycol poisoning treated wtih fomepizole (4-methylpyrazole)] [2002.10.20]

Role of fomepizole in the management of ethylene glycol toxicity. [2002.03]

Treatment of a 1,4-butanediol poisoning with fomepizole. [2002]

Childhood methanol ingestion treated with fomepizole and hemodialysis. [2001.10]

Treatment of acute methanol poisoning with fomepizole. [2001.08]

Fomepizole for the treatment of methanol poisoning. [2001.02.08]

Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole. [2001]

Treatment of methanol and isopropanol poisoning with intravenous fomepizole. [2001]

Fomepizole treatment of ethylene glycol poisoning in an infant. [2000.12]

Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. For the Methylpyrazole for Toxic Alcohols Study Group. [2000.08]

Childhood diethylene glycol poisoning treated with alcohol dehydrogenase inhibitor fomepizole and hemodialysis. [2000.05]

Nystagmus secondary to fomepizole administration in a pediatric patient. [2000]

Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. [1999.03.18]

Fomepizole (4-methylpyrazole) in fatal methanol poisoning with early CT scan cerebral lesions. [1999]

Other possibly related research studies

[Acute methanol intoxication: physiopathology, prognosis and treatment] [2006]

Update on antidotes for pediatric poisoning. [2006.11]

New and novel antidotes in pediatrics. [2006.07]

Prehospital diagnosis of massive ethylene glycol poisoning and use of an early antidote. [2006.08]

Hyperosmolality: another indication for hemodialysis following acute ethylene glycol poisoning. [2006]

The total antioxidant status in the brain after ethanol or 4-methylpyrazole administration to rats intoxicated with methanol. [2006.07]

Resuscitative treatments on 1,4-butanediol mortality in mice. [2006.02]

Methanol outbreak in Norway 2002-2004: epidemiology, clinical features and prognostic signs. [2005.08]

Current recommendations for treatment of severe toxic alcohol poisonings. [2005.02]

Outcomes following abuse of methanol-containing carburetor cleaners. [2004.10]

Aniline and methanol toxicity after shoe dye ingestion. [2004.11]

Ethylene glycol toxicity. [2004.08]

Treatment of severe pediatric ethylene glycol intoxication without hemodialysis. [2004]

Plasma and tissue determination of 4-methylpyrazole for pharmacokinetic analysis in acute adult and pediatric methanol/ethylene glycol poisoning. [2004.06]

Ethylene glycol intoxication: case report and pharmacokinetic perspectives. [2003.12]

Rethinking the toxic methanol level. [2003]

Methanol ingestion: prevention of toxic sequelae after massive ingestion. [2003.05]

Cinnamic compound metabolism in human skin and the role metabolism may play in determining relative sensitisation potency. [2003.02]

Treatment of ethylene glycol poisoning. [2002.09.01]

Mechanism of superoxide anion production by hepatic sinusoidal endothelial cells and Kupffer cells during short-term ethanol perfusion in the rat. [2002.08]

American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. [2002]

Suppression of the contact hypersensitivity response following topical exposure to 2-butoxyethanol in female BALB/c mice. [2002.03]

Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats. [2002]

Concurrent administration of diethyldithiocarbamate and 4-methylpyrazole enhances ethanol-induced locomotor activity: the role of brain ALDH. [2002.04]

Current management of ethylene glycol poisoning. [2001]

4-Methylpyrazole decreases salivary acetaldehyde levels in aldh2-deficient subjects but not in subjects with normal aldh2. [2001.06]

Severe ethylene glycol ingestion treated without hemodialysis. [2001.01]

Diagnosis and treatment of an unusual cause of metabolic acidosis: ethylene glycol poisoning. [1999.12]

Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. [2000.02.16]

Survey of the stocking of poison antidotes in Alabama hospitals. [1999.12]

Two cases of acute methanol poisoning partially treated by oral 4-methylpyrazole. [1999.05]

Novel therapies for ethylene glycol intoxication. [1999.06]

Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group. [1998]

Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes. [1998.11]

Mechanisms of inactivation of hepatocyte protein kinase C isoforms following acute ethanol treatment. [1998.09]

Ethylene glycol poisoning in a child treated with 4-methylpyrazole. [1998.09]

Ethylene glycol poisoning treated by intravenous 4-methylpyrazole. [1998.07]

Gastroprotection by 4-methylpyrazole against ethanol in humans. [1998.04]

Treatment of methanol poisoning with intravenous 4-methylpyrazole. [1997.12]

Ethylene glycol poisoning: case report of a record-high level and a review. [1997.09]

High-performance liquid chromatographic determination of 4-methylpyrazole in plasma and in dialysate. [1997.08.01]

Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. [1997.02]

Intravenous 4-methylpyrazole as an antidote for diethylene glycol and triethylene glycol poisoning: a case report. [1997.02]

Safety and efficacy of 4-methylpyrazole for treatment of suspected or confirmed ethylene glycol intoxication in dogs: 107 cases (1983-1995). [1996.12.01]

Effect of acetaldehyde generated from ethanol by ADH-transfected CHO cells on their membrane fatty acid profiles. [1996.11]

4-Methylpyrazole and hemodialysis in ethylene glycol poisoning. [1996]

4-methylpyrazole monitoring during haemodialysis of ethylene glycol intoxicated patients. [1995]

4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat. [1994.03]

An in vitro model of ethanol-dependent liver cell injury. [1994.01]

Efficacy of 4-methylpyrazole in ethylene glycol poisoning: clinical and toxicokinetic aspects. [1994.01]

Effects of ethanol on urinary acidification and on gluconeogenesis by isolated renal tubules. [1993.10]

Acute ethanol intoxication stimulates superoxide anion production by in situ perfused rat liver. [1992.05]

[Do antidotes have a future? The example of 4-methylpyrazole and hydroxocobalamin] [1992.02]

NADPH-dependent reduction of amaranch in liver microsomes characterized the quantity of low spin forms of cytochrome P-450. [1991.09.16]

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