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Antivert (Meclizine HCl) - Description and Clinical Pharmacology

 
 



ANTIVERT®
Tablets/12.5 mg meclizine HCl

ANTIVERT®/25
Tablets/25 mg meclizine HCl

ANTIVERT®/50
Tablets/50 mg meclizine HCl

DESCRIPTION

Chemically, Antivert® (meclizine HCl) is 1-(p-chloro-(alpha)-phenylbenzyl)-4-(m-methylbenzyl) piperazine dihydrochloride monohydrate.

Antivert_meclizine_SF.gif

Inert ingredients for the tablets are: dibasic calcium phosphate; magnesium stearate; polyethylene glycol; starch; sucrose. The 12.5 mg tablets also contain: Blue 1. The 25 mg tablets also contain: Yellow 6 Lake; Yellow 10 Lake. The 50 mg tablets also contain: Blue 1 Lake; Yellow 10 Lake.

ACTIONS

Antivert is an antihistamine which shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum.

Clinical Pharmacology

No information provided.

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