DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Antivert (Meclizine HCl) - Summary

 
 



ANTIVERT SUMMARY

Antivert® (meclizine HCl) is an antihistamine.

Based on a review of this drug by the National Academy of Sciences-National Research Council and/or other information, FDA has classified the indications as follows:

Effective: Management of nausea and vomiting, and dizziness associated with motion sickness.

Possibly Effective: Management of vertigo associated with diseases affecting the vestibular system.
See all Antivert indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Antivert (Meclizine)

Biphasic dosing regimen of meclizine for prevention of postoperative nausea and vomiting in a high-risk population. [2010.02]
The purpose of this study was to determine if giving 50 mg of meclizine the night before and on the day of surgery would effectively reduce postoperative nausea and vomiting (PONV) for the entire 24 hours after surgery in patients identified as being at high risk for PONV Subjects were randomly assigned to receive either 50 mg of oral meclizine (experimental group) or a placebo (control group) the night before and the day of surgery...

Meclizine for prevention of nausea associated with use of emergency contraceptive pills: a randomized trial. [2000.02]
OBJECTIVE: We conducted a randomized trial to determine whether pretreatment with meclizine reduces the incidence of nausea and vomiting associated with the Yuzpe regimen of emergency contraception... CONCLUSION: Meclizine is effective for preventing nausea and vomiting associated with the Yuzpe regimen of emergency contraceptive pills. Women using this drug should be cautioned to anticipate drowsiness.

Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. [1992.11]
Relative daytime drowsiness and performance impairment produced by meclizine and dimenhydrinate was assessed in 24 healthy male volunteers. Subjects received either dimenhydrinate, 100 mg, at 8:00 AM, 12:00 PM, and 4:00 PM; meclizine, 50 mg, at 8:00 AM, with placebo at 12:00 PM and 4:00 PM; or placebo at all three times in this randomized, double-blind, three-way crossover study...

Biphasic dosing regimen of meclizine for prevention of postoperative nausea and vomiting in a high-risk population. [2010]
The purpose of this study was to determine if giving 50 mg of meclizine the night before and on the day of surgery would effectively reduce postoperative nausea and vomiting (PONV) for the entire 24 hours after surgery in patients identified as being at high risk for PONV Subjects were randomly assigned to receive either 50 mg of oral meclizine (experimental group) or a placebo (control group) the night before and the day of surgery...

Withdrawal symptoms after discontinuation of transdermal scopolamine therapy: treatment with meclizine. [2009.11.15]
CONCLUSION: Withdrawal symptoms experienced after removal of a transdermal scopolamine patch were successfully treated with oral meclizine.

more studies >>

Clinical Trials Related to Antivert (Meclizine)

Meclizine as a Potential Smoking Cessation Treatment [Recruiting]
The purpose of this study is to evaluate whether meclizine, an antihistamine used to prevent or treat motion sickness, can help smokers quit smoking. This study will also investigate the potential relationship between genes you have inherited and success in quitting smoking.

The Vertigo Study: Comparison Between Convention Therapy and Vestibular Rehabilitation for Benign Paroxysmal Positional Vertigo (BPPV) in Emergency Department (ED) Patients [Enrolling by invitation]
Benign Paroxysmal Positional Vertigo (BPPV) is a common complaint of emergency department patients. The importance of early diagnosis and treatment can lead to a much improved quality of life for patients afflicted by this ailment. It is the purpose of this study to evaluate and examine two methods of treatment. Patients will be randomized to receive the more common conventional medication therapy versus the canalith repositioning technique. All patients enrolled into this study are emergency department patients who have been diagnosed with BPPV via a positive Dix-Hallpike Maneuver. The hypothesis of this study is that vestibular rehabilitation will allow for resolution of symptoms without the use of conventional medication therapy in the acute management of BPPV in the emergency department patient.

more trials >>

Reports of Suspected Antivert (Meclizine) Side Effects

Depression (7)Blood Cholesterol Abnormal (6)Dizziness (6)Blood Pressure Fluctuation (6)Asthma (5)Drug Hypersensitivity (4)Hypersensitivity (3)Cardiac Disorder (3)Gastrooesophageal Reflux Disease (3)Anxiety (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Antivert has an overall score of 8.33. The effectiveness score is 8.67 and the side effect score is 6.67. The scores are on ten point scale: 10 - best, 1 - worst.
 

Antivert review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Labyrinthitis
Dosage & duration:   25mg taken every 8 hours for the period of 3-4 days around the clock
Other conditions:   none
Other drugs taken:   Multivitamin
  
Reported Results
Benefits:   Decreased the vertigo almost immediately; no further vomiting; I was able to walk and move my head without the awful spinning.
Side effects:   Sedation--I almost the entire time I took the medication...I'm not sure I could have taken this and gone to work.
Comments:   My doctor said the Labyrinthitis is usually preceded by a cold and fluid collects in the inner portion of the ear and causes the dizziness/vomiting. The treatment was symptom relief (using the Meclizine) and the fluid gradually absorbs.

 

Antivert review by 28 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   B.P.P.V. (benign proxysmal positional vertigo)
Dosage & duration:   25 mg taken when i felt dizzy for the period of One prescription... about 4 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   It helped with the dizziness only because it made me so sleepy I couldn't stay up to notice the dizziness!
Side effects:   Sometimes it would make my heart race so fast I wouldn't be able to sleep at night. This happened about 1 out of ever 5 times I took it.
Comments:   It had sedative effects so it just made me want to sleep. It wouldn't have been good for me at treating my dizzy spells while I was at work or in the middle of running errands because I would get much too tired to function safely.

 

Antivert review by 28 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   B.P.P.V. (benign proxysmal positional vertigo)
Dosage & duration:   25 mg taken when i felt dizzy for the period of One prescription... about 4 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   It helped with the dizziness only because it made me so sleepy I couldn't stay up to notice the dizziness!
Side effects:   Sometimes it would make my heart race so fast I wouldn't be able to sleep at night. This happened about 1 out of ever 5 times I took it.
Comments:   It had sedative effects so it just made me want to sleep. It wouldn't have been good for me at treating my dizzy spells while I was at work or in the middle of running errands because I would get much too tired to function safely.

See all Antivert reviews / ratings >>

Page last updated: 2013-02-10

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2014