Antivert (Meclizine HCl) - Summary

ANTIVERT SUMMARY

Antivert® (meclizine HCl) is an antihistamine.

Based on a review of this drug by the National Academy of Sciences-National Research Council and/or other information, FDA has classified the indications as follows:

Effective: Management of nausea and vomiting, and dizziness associated with motion sickness.

Possibly Effective: Management of vertigo associated with diseases affecting the vestibular system.

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NEWS HIGHLIGHTS

Published Studies Related to Antivert (Meclizine)

Meclizine for prevention of nausea associated with use of emergency contraceptive pills: a randomized trial. [2000.02]
OBJECTIVE: We conducted a randomized trial to determine whether pretreatment with meclizine reduces the incidence of nausea and vomiting associated with the Yuzpe regimen of emergency contraception... CONCLUSION: Meclizine is effective for preventing nausea and vomiting associated with the Yuzpe regimen of emergency contraceptive pills. Women using this drug should be cautioned to anticipate drowsiness.

Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. [1992.11]
Relative daytime drowsiness and performance impairment produced by meclizine and dimenhydrinate was assessed in 24 healthy male volunteers. Subjects received either dimenhydrinate, 100 mg, at 8:00 AM, 12:00 PM, and 4:00 PM; meclizine, 50 mg, at 8:00 AM, with placebo at 12:00 PM and 4:00 PM; or placebo at all three times in this randomized, double-blind, three-way crossover study...

Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population. [2007.02]
Postoperative nausea and vomiting (PONV) is prevalent in surgical patients with known risk factors: general anesthesia, female, nonsmoker, motion sickness history, and PONV history. Common treatment involves ondansetron; however, the effects are short-lived, and supplemental medication may be required.

Physiological and behavioral effects of an antivertigo antihistamine in adults. [1999.06]
12 neurologically normal adults were tested before and after administration of meclizine, an over-the-counter medication for motion sickness. A battery of four tests was used: (1) distortion-product otoacoustic emissions, (2) the Repeated Evoked Potentials version of the Auditory Brainstem Response, (3) quantitative electroencephalography measured over the left and right sides of the auditory cortex, and (4) a hand-eye coordination task.

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Clinical Trials Related to Antivert (Meclizine)

The Vertigo Study: Comparison Between Convention Therapy and Vestibular Rehabilitation for Benign Paroxysmal Positional Vertigo (BPPV) in Emergency Department (ED) Patients [Enrolling by invitation]
Benign Paroxysmal Positional Vertigo (BPPV) is a common complaint of emergency department patients. The importance of early diagnosis and treatment can lead to a much improved quality of life for patients afflicted by this ailment. It is the purpose of this study to evaluate and examine two methods of treatment. Patients will be randomized to receive the more common conventional medication therapy versus the canalith repositioning technique. All patients enrolled into this study are emergency department patients who have been diagnosed with BPPV via a positive Dix-Hallpike Maneuver. The hypothesis of this study is that vestibular rehabilitation will allow for resolution of symptoms without the use of conventional medication therapy in the acute management of BPPV in the emergency department patient.

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PATIENT REVIEWS / RATINGS / COMMENTS

Antivert review by 45 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		Labyrinthitis
Dosage & duration:		25mg taken every 8 hours for the period of 3-4 days around the clock
Other conditions:		none
Other drugs taken:		Multivitamin
		Reported Results
Benefits:		Decreased the vertigo almost immediately; no further vomiting; I was able to walk and move my head without the awful spinning.
Side effects:		Sedation--I almost the entire time I took the medication...I'm not sure I could have taken this and gone to work.
Comments:		My doctor said the Labyrinthitis is usually preceded by a cold and fluid collects in the inner portion of the ear and causes the dizziness/vomiting. The treatment was symptom relief (using the Meclizine) and the fluid gradually absorbs.