Ansaid (Flurbiprofen) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

TABLE 2. Reported adverse events in patients receiving ANSAID or other nonsteroidal anti-inflammatory drugs

Reported in patients treated with ANSAID
Incidence of 1% or greaterfrom clinical trials	Incidence < 1% - Causal Relationship Probable 1	Incidence < 1% - Causal Relationship Unknown	Reported in patients treated with other products but not ANSAID
BODY AS A WHOLE
edema	anaphylactic reaction chills fever		< 1%: death infection sepsis
CARDIOVASCULAR SYSTEM
	congestive heart failure hypertension vascular diseases vasodilation	angina pectoris arrhythmias myocardial infarction	< 1%: hypotension palpitations syncope tachycardia vasculitis
DIGESTIVE SYSTEM
abdominal pain   constipation   diarrhea   dyspepsia/heartburn   elevated liver enzymes   flatulence   GI bleeding   nausea   vomiting	bloody diarrhea esophageal disease gastric/peptic ulcer disease gastritis jaundice (cholestatic and noncholestatic) hematemesis hepatitis stomatitis/glossitis	appetite changes cholecystitis colitis dry mouth exacerbation of inflammatory bowel disease periodontal abscess small intestine inflammation with loss of blood and protein	> 1%: GI perforation GI ulcers (gastric/duodenal) < 1%: eructation liver failure pancreatitis
HEMIC AND
LYMPHATIC SYSTEM	aplastic anemia (including agranulocytosis or pancytopenia) decrease in hemoglobin and hematocrit ecchymosis/purpura eosinophilia hemolytic anemia iron deficiency anemia leukopenia thrombocytopenia	lymphadenopathy	> 1%: anemia increased bleeding time < 1%: melena rectal bleeding
METABOLIC AND NUTRITIONAL SYSTEM
body weight changes	hyperuricemia	hyperkalemia	< 1%: hyperglycemia
NERVOUS SYSTEM
headache   nervousness and other manifestations of central nervous system (CNS) stimulation (eg, anxiety, insomnia, increased reflexes, tremor)   symptoms associated with CNS inhibition (eg, amnesia, asthenia, depression, malaise, somnolence)	ataxia cerebrovascular ischemia confusion paresthesia twitching	convulsion cerebrovascular accident emotional lability hypertonia meningitis myasthenia subarachnoid hemorrhage	< 1%: coma dream abnormalities drowsiness hallucinations
RESPIRATORY SYSTEM
rhinitis	asthma epistaxis	bronchitis dyspnea hyperventilation laryngitis pulmonary embolism pulmonary infarct	< 1%: pneumonia respiratory depression
SKIN AND APPENDAGES
rash	angioedema eczema exfoliative dermatitis photosensitivity pruritus toxic epidermal necrolysis urticaria	alopecia dry skin herpes simplex/zoster nail disorder sweating	< 1%: erythema multiforme Stevens Johnson syndrome
SPECIAL SENSES
changes in vision   dizziness/vertigo   tinnitus	conjunctivitis parosmia	changes in taste corneal opacity ear disease glaucoma retinal hemorrhage retrobulbar neuritis transient hearing loss	> 1%: pruritus < 1%: hearing impairment
UROGENITAL SYSTEM
signs and symptoms suggesting urinary tract infection	hematuria interstitial nephritis renal failure	menstrual disturbances prostate disease vaginal and uterine hemorrhage vulvovaginitis	> 1%: abnormal renal function < 1%: dysuria oliguria polyuria proteinuria