Media Articles Related to Angiomax (Bivalirudin)
New Revascularization Guidelines Trim Back Bivalirudin, DAPT
Source: theheart.org | Medscape Cardiology Headlines [2014.09.11]
New European guidelines for PCI and CABG in stable CAD, NSTEMI, and STEMI were unveiled last week with some key changes from previous documents.
PREFER in VTE registry reveals new insights into use of Novel Oral Anticoagulants (NOACs) in the treatment and management of venous thromboembolism
Source: Clinical Trials / Drug Trials News From Medical News Today [2014.09.05]
Daiichi Sankyo Europe GmbH has announced snapshot results from the PREvention oF thromboembolic events - European Registry in Venous ThromboEmbolism (PREFER in VTE), including initial baseline...
Novel oral anticoagulant prescriptions soar, but at a high cost
Source: Blood / Hematology News From Medical News Today [2014.08.21]
Warfarin, the longtime standard treatment for atrial fibrillation, is facing competition from new options in the anticoagulant drug marketplace including dabigatran, rivaroxaban, and apixaban.
Supplement on management of anticoagulant-associated intracerebral hemorrhage
Source: Medical Students / Training News From Medical News Today [2014.08.05]
The Journal of Neurosurgery is pleased to announce publication of a supplement to the August issue entitled "Race Against the Clock: Overcoming Challenges in the Management of...
When warfarin cannot be used, aspirin may reduce the risks of reoccurring blood clots
Source: Blood / Hematology News From Medical News Today [2014.08.27]
Aspirin may be a promising alternative for those who can't take long-term anticoagulant drugs that prevent clots from reoccurring in the veins, according to new research in the American Heart...
Published Studies Related to Angiomax (Bivalirudin)
The effect of bivalirudin on costs and outcomes of treatment of ST-segment elevation myocardial infarction. [2011.09]
BACKGROUND: Bivalirudin is commonly used during percutaneous coronary intervention (PCI) rather than unfractionated heparin. The higher cost of bivalirudin may be offset if it reduces costly bleeding complications and/or length of stay. We sought to assess the effect of using bivalirudin on the costs of care among patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI... CONCLUSIONS: Use of bivalirudin among patients with STEMI treated with PCI appears to reduce bleeding and overall costs. Copyright (c) 2011 Mosby, Inc. All rights reserved.
Heparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (HORIZONS-AMI): final 3-year results from a multicentre, randomised controlled trial. [2011.06.25]
BACKGROUND: Primary results of the HORIZONS-AMI trial have been previously reported. In this final report, we aimed to assess 3-year outcomes... INTERPRETATION: The effectiveness and safety of bivalirudin monotherapy and paclitaxel-eluting stenting are sustained at 3 years for patients with STEMI undergoing primary percutaneous coronary intervention. FUNDING: Boston Scientific and The Medicines Company. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
A randomized two-by-two comparison of high-dose bolus tirofiban versus abciximab and unfractionated heparin versus bivalirudin during percutaneous coronary revascularization and stent placement: the tirofiban evaluation of novel dosing versus abciximab with clopidogrel and inhibition of thrombin (TENACITY) study trial. [2011.06.01]
CONCLUSION: With limited assessment, this direct comparison of high-dose bolus tirofiban versus abciximab produced encouraging results and suggests that further study of this tirofiban dose regimen is warranted. The limited assessments comparing heparin and bivalirudin are consistent with prior observations. Copyright (c) 2010 Wiley-Liss, Inc.
Heparin versus bivalirudin for carotid artery stenting using proximal endovascular clamping for neuroprotection: results from a prospective randomized study. [2010.12]
BACKGROUND: General recommendations indicate that, during a carotid artery stenting (CAS), sufficient unfractionated heparin (UFH) has to be given to maintain the activated clotting time between 250 to 300 seconds. Bivalirudin use is able to reduce postprocedural bleedings in percutaneous interventions when compared with UFH. The study purpose was to evaluate, in a randomized study, the safety and efficacy of bivalirudin versus heparin during CAS, using proximal endovascular occlusion (PEO) as a distal protection device... CONCLUSIONS: The use of bivalirudin should be considered a safe and effective anticoagulation regimen during CAS, using PEO as a distal protection device. Bivalirudin use is associated with a reduced incidence of bleedings. Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
A randomized two-by-two comparison of high-dose bolus tirofiban versus abciximab and unfractionated heparin versus bivalirudin during percutaneous coronary revascularization and stent placement: The tirofiban evaluation of novel dosing versus abciximab with clopidogrel and inhibition of thrombin (TENACITY) study trial. [2010.11.08]
Background: In the absence of high-dose thienopyridines, placebo-controlled trials have demonstrated a reduction in ischemic events with intravenous glycoprotein IIb/IIIa antagonists during percutaneous coronary intervention (PCI)... The limited assessments comparing heparin and bivalirudin are consistent with prior observations.
Clinical Trials Related to Angiomax (Bivalirudin)
Study Of Angiomax In Infants Under Six Months With Thrombosis [Completed]
The goals of this study are:
1. To assess the safety of bivalirudin in infants under six months with arterial or venous
2. To determine the dose of bivalirudin required to achieve adequate anticoagulation as
measured by the activated clotting time (ACT) or activated partial thromboplastin time
(aPTT) in Infants Under Six Months with arterial or venous thrombosis;
3. To determine the outcome of patients on bivalirudin with respect to thrombus resolution
and bleeding complications compared to patients on unfractionated heparin (UH) or low
molecular weight heparin (LMWH).
Antithrombotic Effects of Ticagrelor Versus Clopidogrel [Recruiting]
The purpose of this study is to determine whether treatment with ticagrelor (plus aspirin
and bivalirudin) is more effective than treatment with clopidogrel (plus aspirin and
Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS) [Completed]
The purpose of this study is to show that, when compared with heparin (enoxaparin or
unfractionated heparin) and routine GPIIb/IIIa inhibition (either started upfront or at the
time of percutaneous coronary intervention [PCI]; Arm A):
1. Bivalirudin with routine GPIIb/IIIa inhibition (either started upfront or at the time of
PCI; Arm B) provides non-inferior or superior overall clinical outcomes and
2. Bivalirudin alone (Arm C) reduces clinically significant bleeding. An important
secondary objective for this comparison is to show that bivalirudin is not inferior for
Angiomax® or Unfractionated Heparin for Patients Undergoing Percutaneous Coronary Intervention [Recruiting]
The objective of the study is to assess the safety and efficacy of Angiomax® (bivalirudin)
versus unfractionated heparin (UFH) in patients presenting with stable angina or silent
ischemia (positive stress test without chest pain) that undergo percutaneous coronary
The primary endpoint of the study will be major and minor bleeding events, defined by the
REPLACE-2 trial definition, during the index hospitalization and up to 30 days post
Peri-Procedural Myocardial Infarction, Platelet Reactivity, Thrombin Generation, and Clot Strength: Differential Effects of Eptifibatide + Bivalirudin Versus Bivalirudin [Recruiting]
The purpose of this study is to compare levels of clot formation (platelet aggregation),
markers of heart muscle damage, and inflammation in two groups undergoing percutaneous
coronary stent implantation. The first group will be on a regimen of high-dose clopidogrel
used in combination with bivalirudin plus eptifibatide, and the second group will be on a
regimen of high-dose clopidogrel with bivalirudin alone. Clinical outcomes will be
determined up to one year after enrollment.
Reports of Suspected Angiomax (Bivalirudin) Side Effects
Thrombosis in Device (18),
OFF Label USE (10),
Coronary Artery Thrombosis (6),
Acute Myocardial Infarction (6),
Myocardial Infarction (6),
Drug Ineffective (4),
Chest Pain (4),
Coronary Artery Occlusion (4),
Procedural Complication (4), more >>