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Ancobon (Flucytosine) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

Drug Interactions

Cytosine arabinoside, a cytostatic agent, has been reported to inactivate the antifungal activity of Ancobon by competitive inhibition. Drugs which impair glomerular filtration may prolong the biological half-life of flucytosine.

OVERDOSAGE

There is no experience with intentional overdosage. It is reasonable to expect that overdosage may produce pronounced manifestations of the known clinical adverse reactions. Prolonged serum concentrations in excess of 100 µg/mL may be associated with an increased incidence of toxicity, especially gastrointestinal (diarrhea, nausea, vomiting), hematologic (leukopenia, thrombocytopenia) and hepatic (hepatitis).

In the management of overdosage, prompt gastric lavage or the use of an emetic is recommended. Adequate fluid intake should be maintained, by the intravenous route if necessary, since Ancobon is excreted unchanged via the renal tract. The hematologic parameters should be monitored frequently; liver and kidney function should be carefully monitored. Should any abnormalities appear in any of these parameters, appropriate therapeutic measures should be instituted.

Since hemodialysis has been shown to rapidly reduce serum concentrations in anuric patients, this method may be considered in the management of overdosage.

CONTRAINDICATIONS

Ancobon should not be used in patients with a known hypersensitivity to the drug.

REFERENCES

  1.  Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-Second Edition. NCCLS Document M27-A2, 2002 Volume 22, No 15, NCCLS, Wayne, PA, August 2002.

Manufactured by:
LEGACY PHARMACEUTICALS PUERTO RICO, LLC
Bo. Mariana Rd 909, KM 1.1, Humacao, PR 00791

Distributed by:
VALEANT PHARMACEUTICALS NORTH AMERICA
One Enterprise
Aliso Viejo, CA 92656 USA
(800)-548-5100

02-3554-01
Rev. February 2011

Ancobon 500 mg capsules are available from Cardinal Health in unit dose packages of

100 capsules.

500 mg, unit dose package of 100 capsules, NDC 55154-6575-4

Cardinal Health

Zanesville OH 43701

IU39992160109

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