INDICATIONS AND USAGE
ANCEF is indicated in the treatment of the following infections due to susceptible organisms:
Respiratory Tract Infections
Due to S. pneumoniae, S aureus (including β-lactamase−producing strains) and S. pyogenes.
Injectable benzathine penicillin is considered to be the drug of choice in treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever.
ANCEF is effective in the eradication of streptococci from the nasopharynx; however, data establishing the efficacy of ANCEF in the subsequent prevention of rheumatic fever are not available.
Urinary Tract Infections
Due to E. coli, P mirabilis.
Skin and Skin Structure Infections
Due to S. aureus (including β-lactamase−producing strains), S. pyogenes, and other strains of streptococci.
Biliary Tract Infections
Due to E. coli, various strains of streptococci, P. mirabilis, and S. aureus.
Bone and Joint Infections
Due to S. aureus.
(i.e., prostatitis, epididymitis) due to E. coli, P. mirabilis.
Due to S. pneumoniae, S. aureus (including β-lactamase−producing strains), P. mirabilis, E. coli.
Due to S. aureus (including β-lactamase−producing strains) and S. pyogenes.
Appropriate culture and susceptibility studies should be performed to determine susceptibility of the causative organism to ANCEF.
The prophylactic administration of ANCEF preoperatively, intraoperatively, and postoperatively may reduce the incidence of certain postoperative infections in patients undergoing surgical procedures which are classified as contaminated or potentially contaminated (e.g., vaginal hysterectomy, and cholecystectomy in high-risk patients such as those older than 70 years, with acute cholecystitis, obstructive jaundice, or common duct bile stones).
The perioperative use of ANCEF may also be effective in surgical patients in whom infection at the operative site would present a serious risk (e.g., during open-heart surgery and prosthetic arthroplasty).
The prophylactic administration of ANCEF should usually be discontinued within a 24-hour period after the surgical procedure. In surgery where the occurrence of infection may be particularly devastating (e.g., open-heart surgery and prosthetic arthroplasty), the prophylactic administration of ANCEF may be continued for 3 to 5 days following the completion of surgery.
If there are signs of infection, specimens for cultures should be obtained for the identification of the causative organism so that appropriate therapy may be instituted.
(See DOSAGE AND ADMINISTRATION.)
To reduce the development of drug-resistant bacteria and maintain the effectiveness of ANCEF and other antibacterial drugs, ANCEF should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.