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Ampyra (Dalfampridine) - Summary

 
 



AMPYRA SUMMARY

AMPYRA (dalfampridine) is a potassium channel blocker, available in a 10 mg tablet strength.

AMPYRA (dalfampridine) is indicated as a treatment to improve walking in patients with multiple sclerosis (MS). This was demonstrated by an increase in walking speed [see Clinical Studies].


See all Ampyra indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ampyra (Dalfampridine)

Research my lead to development of novel therapeutic agents for multiple sclerosis
Source: Multiple Sclerosis News From Medical News Today [2014.04.03]
Just a few short weeks ago, dimethyl fumarate was approved in Europe as a basic therapy for multiple sclerosis.

Researchers testing gene therapy to thwart effects of multiple sclerosis
Source: Multiple Sclerosis News From Medical News Today [2014.04.01]
In patients with multiple sclerosis, the body turns on itself, launching an immune system attack that destroys the coating around nerve fibers in the central nervous system, leaving them exposed like...

Natalizumab treatment in patients with multiple sclerosis associated with JC virus infection
Source: Multiple Sclerosis News From Medical News Today [2014.03.24]
Treatment with natalizumab in patients with multiple sclerosis (MS) appears linked with JC virus (JCV) infection, which can lead to a rare and often fatal demyelinating disease of the central nervous...

Multiple sclerosis: raising awareness of a complex disease
Source: Multiple Sclerosis News From Medical News Today [2014.03.21]
This March is National MS Awareness Month. We cover the symptoms, diagnosis and treatment of the disease, and look at what is being done to increase awareness of the condition.

Statins slow the progression of advanced multiple sclerosis in clinical trial
Source: Multiple Sclerosis News From Medical News Today [2014.03.19]
Statins may provide doctors with an unlikely new weapon with which to slow the progression of multiple sclerosis (MS).

more news >>

Published Studies Related to Ampyra (Dalfampridine)

Dalfampridine extended release: in multiple sclerosis. [2010.10.01]
Dalfampridine extended release (ER) is an orally administered formulation of dalfampridine (fampridine, 4-aminopyridine), a potassium channel antagonist indicated for the improvement in walking ability in patients with multiple sclerosis (MS). Oral dalfampridine ER improved walking ability in patients with MS in three randomized, double-blind trials of up to 15 weeks' duration...

A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. [2010.10]
OBJECTIVE: A previous phase 3 study showed significant improvement in walking ability in multiple sclerosis (MS) patients treated with oral, extended-release dalfampridine (4-aminopyridine) 10mg twice daily. The current study was designed to confirm efficacy and further define safety and pharmacodynamics... INTERPRETATION: This interventional study provides class 1 evidence that dalfampridine extended-release tablets produce clinically meaningful improvement in walking ability in a subset of people with MS, with the effect maintained between doses.

A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. [2010]
to confirm efficacy and further define safety and pharmacodynamics... INTERPRETATION: This interventional study provides class 1 evidence that

Dalfampridine: a brief review of its mechanism of action and efficacy as a treatment to improve walking in patients with multiple sclerosis. [2011.07]
BACKGROUND: Multiple sclerosis (MS) can cause progressive walking impairment that contributes to disability, loss of independence, and reduced quality of life. Dalfampridine (4-aminopyridine), a voltage-dependent potassium channel blocker, has been shown to improve walking in patients with MS, as demonstrated by an increase in walking speed. OBJECTIVE: To summarize knowledge about the mechanism of action of dalfampridine in the context of clinical evidence of walking improvement in MS patients... CONCLUSIONS: The extended-release formulation of dalfampridine has been shown in clinical trials to improve walking speed in approximately one third of MS patients with ambulatory impairment. The putative mechanism of action of dalfampridine is restoration of action potential conduction via blockade of an as yet uncharacterized subset of potassium channels in demyelinated axons.

Treatment of walking impairment in multiple sclerosis with dalfampridine. [2011.03]
Potassium channel blockade has long been considered a potential therapeutic strategy for treatment of multiple sclerosis (MS) based on the pathophysiology of demyelinated axons. Dalfampridine, which is also known as fampridine or 4-aminopyridine (4-AP), is the potassium channel blocker that has been studied most extensively in MS and other demyelinating neurologic disorders...

more studies >>

Clinical Trials Related to Ampyra (Dalfampridine)

A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease [Recruiting]
The purpose of this study is to evaluate the effect of AMPYRA on a number of symptoms in Parkinson's disease. AMPYRA is a medication approved by FDA for gait dysfunction in multiple sclerosis. There are multiple studies to suggest that persons with multiple sclerosis benefit from this medication and have major improvements in gait after taking this medication. However, this medication was never studied in Parkinson's disease. This study aims to learn about possible benefits of AMPYRA in Parkinson's disease (PD).

Study of Fampridine-ER Tablets in Patients With Multiple Sclerosis [Recruiting]
The purpose of this study is to investigate the safety and efficacy of a lower dose of dalfampridine extended release tablets compared to the currently approved dose in improving walking in Multiple Sclerosis patients.

Safety and Efficacy of Dalfampridine in Patients With Cerebral Palsy [Recruiting]
A double-blind, placebo-controlled, crossover study in patients with cerebral palsy (CP) to evaluate the effect of a single dose of dalfampridine extended release (ER) tablets on sensorimotor function

Ampyra for Optic Neuritis in MS [Recruiting]
Fifty subjects will be enrolled in this Phase II, investigator-initiated, randomized and blinded cross-over trial of dalfampridine of 8 weeks duration The study will test the hypothesis that dalfampridine, when administered to subjects with incomplete visual recovery after optic neuritis from MS, will result in symptomatic improvement in visual function. The study will consist of one screening/baseline visit, one visit during treatment with active drug, and one visit on placebo. After the baseline visit, subjects will be randomly assigned to receive study medication or placebo for the first three weeks, followed by a two week wash-out, and then treatment reallocation for the latter three weeks.

Short and Long Term Treatment With 4-AP in Ambulatory SMA Patients [Recruiting]
The purpose of this study is to assess whether 4-AP (Ampyra) improves walking ability and endurance in adult patients with SMA Type 3 compared to placebo and whether the duration of treatment affects outcome.

more trials >>

Reports of Suspected Ampyra (Dalfampridine) Side Effects

Convulsion (149)Fall (90)Gait Disturbance (64)Urinary Tract Infection (63)Abasia (57)Inappropriate Schedule of Drug Administration (57)Multiple Sclerosis Relapse (52)Dizziness (48)Asthenia (40)Nausea (37)more >>


Page last updated: 2014-04-03

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