Media Articles Related to Ampyra (Dalfampridine)
Sleep problems may be a hidden epidemic among individuals with multiple sclerosis
Source: Multiple Sclerosis News From Medical News Today [2014.09.16]
In what may be the largest study of sleep problems among individuals with multiple sclerosis (MS), researchers at UC Davis have found that widely undiagnosed sleep disorders may be at the root of the...
Multiple Sclerosis Risk Tied to Some OCs
Source: MedPage Today Neurology [2014.09.16]
BOSTON (MedPage Today) -- Women using combined oral contraceptives containing norethindrone or levonorgestrel were substantially more likely to develop multiple sclerosis than those not on "The Pill."
Study: Undiagnosed Sleep Disorders Common With Multiple Sclerosis
Source: MedicineNet Sleep Specialty [2014.09.15]
Title: Study: Undiagnosed Sleep Disorders Common With Multiple Sclerosis
Category: Health News
Created: 9/12/2014 4:36:00 PM
Last Editorial Review: 9/15/2014 12:00:00 AM
At four years, treatment effect maintained in more than two-thirds of patients who received Lemtrada in multiple sclerosis pivotal studies
Source: Clinical Trials / Drug Trials News From Medical News Today [2014.09.12]
Sanofi and its subsidiary Genzyme has announced positive interim results from the second year of the extension study of Lemtrada(TM) (alemtuzumab) for multiple sclerosis.
Interventions targeted at working memory in people with multiple sclerosis may help build cognitive reserve
Source: Multiple Sclerosis News From Medical News Today [2014.09.12]
Kessler Foundation scientists have shown that working memory may be an underlying mechanism of cognitive reserve in multiple sclerosis (MS).
Published Studies Related to Ampyra (Dalfampridine)
Dalfampridine extended release: in multiple sclerosis. [2010.10.01]
Dalfampridine extended release (ER) is an orally administered formulation of dalfampridine (fampridine, 4-aminopyridine), a potassium channel antagonist indicated for the improvement in walking ability in patients with multiple sclerosis (MS). Oral dalfampridine ER improved walking ability in patients with MS in three randomized, double-blind trials of up to 15 weeks' duration...
A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. [2010.10]
OBJECTIVE: A previous phase 3 study showed significant improvement in walking ability in multiple sclerosis (MS) patients treated with oral, extended-release dalfampridine (4-aminopyridine) 10mg twice daily. The current study was designed to confirm efficacy and further define safety and pharmacodynamics... INTERPRETATION: This interventional study provides class 1 evidence that dalfampridine extended-release tablets produce clinically meaningful improvement in walking ability in a subset of people with MS, with the effect maintained between doses.
A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. 
to confirm efficacy and further define safety and pharmacodynamics... INTERPRETATION: This interventional study provides class 1 evidence that
Dalfampridine: a brief review of its mechanism of action and efficacy as a treatment to improve walking in patients with multiple sclerosis. [2011.07]
BACKGROUND: Multiple sclerosis (MS) can cause progressive walking impairment that contributes to disability, loss of independence, and reduced quality of life. Dalfampridine (4-aminopyridine), a voltage-dependent potassium channel blocker, has been shown to improve walking in patients with MS, as demonstrated by an increase in walking speed. OBJECTIVE: To summarize knowledge about the mechanism of action of dalfampridine in the context of clinical evidence of walking improvement in MS patients... CONCLUSIONS: The extended-release formulation of dalfampridine has been shown in clinical trials to improve walking speed in approximately one third of MS patients with ambulatory impairment. The putative mechanism of action of dalfampridine is restoration of action potential conduction via blockade of an as yet uncharacterized subset of potassium channels in demyelinated axons.
Treatment of walking impairment in multiple sclerosis with dalfampridine. [2011.03]
Potassium channel blockade has long been considered a potential therapeutic strategy for treatment of multiple sclerosis (MS) based on the pathophysiology of demyelinated axons. Dalfampridine, which is also known as fampridine or 4-aminopyridine (4-AP), is the potassium channel blocker that has been studied most extensively in MS and other demyelinating neurologic disorders...
Clinical Trials Related to Ampyra (Dalfampridine)
A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease [Recruiting]
The purpose of this study is to evaluate the effect of AMPYRA on a number of symptoms in
Parkinson's disease. AMPYRA is a medication approved by FDA for gait dysfunction in
multiple sclerosis. There are multiple studies to suggest that persons with multiple
sclerosis benefit from this medication and have major improvements in gait after taking this
medication. However, this medication was never studied in Parkinson's disease. This study
aims to learn about possible benefits of AMPYRA in Parkinson's disease (PD).
Study of Fampridine-ER Tablets in Patients With Multiple Sclerosis [Recruiting]
The purpose of this study is to investigate the safety and efficacy of a lower dose of
dalfampridine extended release tablets compared to the currently approved dose in improving
walking in Multiple Sclerosis patients.
Safety and Efficacy of Dalfampridine in Patients With Cerebral Palsy [Recruiting]
A double-blind, placebo-controlled, crossover study in patients with cerebral palsy (CP) to
evaluate the effect of a single dose of dalfampridine extended release (ER) tablets on
Ampyra for Optic Neuritis in MS [Recruiting]
Fifty subjects will be enrolled in this Phase II, investigator-initiated, randomized and
blinded cross-over trial of dalfampridine of 8 weeks duration The study will test the
hypothesis that dalfampridine, when administered to subjects with incomplete visual recovery
after optic neuritis from MS, will result in symptomatic improvement in visual function. The
study will consist of one screening/baseline visit, one visit during treatment with active
drug, and one visit on placebo. After the baseline visit, subjects will be randomly assigned
to receive study medication or placebo for the first three weeks, followed by a two week
wash-out, and then treatment reallocation for the latter three weeks.
Short and Long Term Treatment With 4-AP in Ambulatory SMA Patients [Recruiting]
The purpose of this study is to assess whether 4-AP (Ampyra) improves walking ability and
endurance in adult patients with SMA Type 3 compared to placebo and whether the duration of
treatment affects outcome.
Reports of Suspected Ampyra (Dalfampridine) Side Effects
Gait Disturbance (64),
Urinary Tract Infection (63),
Inappropriate Schedule of Drug Administration (57),
Multiple Sclerosis Relapse (52),
Nausea (37), more >>