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Ampicillin (Ampicillin Sodium) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

As with other penicillins, it may be expected that untoward reactions will be essentially limited to sensitivity phenomena. They are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergy, asthma, hay fever, or urticaria.

The following adverse reactions have been reported as associated with the use of ampicillin:

Gastrointestinal

Glossitis, stomatitis, black hairy tongue, nausea, vomiting, enterocolitis, pseudomembranous colitis, and diarrhea. (These reactions are usually associated with oral dosage forms.)

Hypersensitivity Reactions

Skin rashes and urticaria have been reported frequently. A few cases of exfoliative dermatitis and erythema multiforme have been reported. Anaphylaxis is the most serious reaction experienced and has usually been associated with the parenteral dosage form.

Note: Urticaria, other skin rashes, and serum sickness-like reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, ampicillin should be discontinued, unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to ampicillin therapy. Serious anaphylactic reactions require the immediate use of epinephrine, oxygen, and intravenous steroids.

Liver– A moderate rise in serum glutamic oxaloacetic transaminase (SGOT) has been noted, particularly in infants, but the significance of this finding is unknown. Mild transitory SGOT elevations have been observed in individuals receiving larger (two to four times) than usual and oft-repeated intramuscular injections. Evidence indicates that glutamic oxaloacetic transaminase (GOT) is released at the site of intramuscular injection of ampicillin sodium and that the presence of increased amounts of this enzyme in the blood does not necessarily indicate liver involvement.

Hemic and Lymphatic Systems– Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with the penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.



REPORTS OF SUSPECTED AMPICILLIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Ampicillin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Ampicillin side effects / adverse reactions in 53 year old male

Reported by a pharmacist from United States on 2011-10-31

Patient: 53 year old male weighing 81.0 kg (178.2 pounds)

Reactions: Dyspnoea, Hypoxia, Rash

Adverse event resulted in: hospitalization

Suspect drug(s):
Ampicillin



Possible Ampicillin side effects / adverse reactions in 48 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-12-20

Patient: 48 year old female

Reactions: Overdose, Hepatic Necrosis, Metabolic Acidosis, Renal Failure, Hypoglycaemia, Toxicity TO Various Agents

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Diazepam
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Acetaminophen
    Dosage: 3.5 g, qd
    Administration route: Oral
    Indication: Back Pain

Ampicillin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Meperidine HCL
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Cimetidine



Possible Ampicillin side effects / adverse reactions in 11 year old male

Reported by a pharmacist from Japan on 2011-12-27

Patient: 11 year old male

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Suspect drug(s):
Depas
    Dosage: 1 df, uid/qd
    Administration route: Oral
    Start date: 2010-07-01
    End date: 2010-07-01

Omeprazole
    Dosage: 7.5 mg, 2x/day
    Start date: 2010-07-16
    End date: 2010-07-21

Heparin
    Dosage: 2 df, uid/qd
    Start date: 2010-06-17

Epinephrine
    Dosage: 10 mg, uid/qd
    Start date: 2010-06-21
    End date: 2010-06-21

Cefazolin Sodium
    Dosage: 500 mg, 2x/day
    Start date: 2010-06-22
    End date: 2010-06-24

Midazolam
    Dosage: 10 mg uid/qd
    Start date: 2010-06-21
    End date: 2010-06-21

Phenobarbital TAB
    Dosage: 50 mg, 2x/day
    Administration route: Oral
    Start date: 2010-06-22
    End date: 2010-07-09

Diazepam
    Dosage: 4 ml
    Administration route: Oral
    Start date: 2010-07-02
    End date: 2010-07-22

Decadron
    Dosage: 2 mg
    Start date: 2010-06-17
    End date: 2010-06-22

Nicardipine HCL
    Dosage: unk

Panthenol
    Dosage: 25 mg, 2x/day
    Start date: 2010-06-04
    End date: 2010-07-05

Famotidine
    Dosage: 15 mg, unk
    Administration route: Oral
    Start date: 2010-06-26
    End date: 2010-07-15

Midazolam
    Dosage: 10 mg, 1x/day
    Start date: 2010-06-17
    End date: 2010-07-09

Ampicillin
    Dosage: 375 mg, 1x/day
    Start date: 2010-07-15
    End date: 2010-07-16

Cefazolin Sodium
    Dosage: 1g, unk
    Administration route: Oral
    Start date: 2010-07-11
    End date: 2010-07-18

Rocuronium Bromide
    Dosage: 50 mg, 1x/day
    Start date: 2010-06-17
    End date: 2010-07-06

Flurbiprofen
    Dosage: 3.5 ml, 1x/day
    Start date: 2010-07-09
    End date: 2010-07-09

Clindamycin Phosphate
    Dosage: 100 mg, 3x/day
    Start date: 2010-06-08
    End date: 2010-07-10

Acetaminophen
    Dosage: 300 mg, 1x/day
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2010-06-27
    End date: 2010-07-16

Morphine Hydrochloride
    Dosage: 2 mg/kg, 1x/day
    Start date: 2010-06-21
    End date: 2010-07-09

Lasix
    Dosage: 2.5 mg qid
    Administration route: Oral
    Start date: 2010-06-26
    End date: 2010-07-06

Tricloryl
    Dosage: 20 ml, uid/qd
    Administration route: Oral
    Start date: 2010-06-28
    End date: 2010-07-05

Laxoberon
    Dosage: 10 ml, uid/qd
    Administration route: Oral
    Start date: 2010-06-20
    End date: 2010-06-20

Xylocaine
    Dosage: 10 ml, 1x/day
    Start date: 2010-06-21
    End date: 2010-07-09

Glycerin
    Dosage: unk
    Indication: Constipation
    Start date: 2010-06-27

Rocephin
    Dosage: 2000 mg, 1x/day
    Indication: Infection
    Start date: 2010-06-30
    End date: 2010-07-07

Risperdal
    Dosage: 0.3 ml, 1x/day
    Administration route: Oral
    Start date: 2010-07-02
    End date: 2010-07-14

Cefazolin Sodium
    Dosage: 1 g, unk
    Administration route: Oral
    Start date: 2010-07-11
    End date: 2010-07-18

Lactobacillus Casei
    Dosage: 500 mg
    Administration route: Oral
    Start date: 2010-07-02
    End date: 2010-07-09

Fentanyl
    Dosage: unk
    Start date: 2010-06-21
    End date: 2010-07-08

Atarax
    Dosage: 25 mg, 1x/day
    Start date: 2010-07-09
    End date: 2010-07-09

Famotidine
    Dosage: 8 mg,
    Start date: 2010-06-17
    End date: 2010-06-26

Piperacillin Sodium
    Dosage: 375 mg, qid
    Start date: 2010-07-15
    End date: 2010-07-16

Aldactone
    Dosage: 2.5 mg qid
    Administration route: Oral
    Start date: 2010-06-26
    End date: 2010-07-06

Atropine Sulfate
    Dosage: 0.5 mg, uid/qd
    Start date: 2010-06-17
    End date: 2010-06-22

Ultiva
    Dosage: unk
    Start date: 2010-06-21
    End date: 2010-07-08

Dexmedetomidine Hydrochloride
    Dosage: unk
    Start date: 2010-07-04
    End date: 2010-07-05

Diazepam
    Dosage: 5 mg, unk
    Administration route: Oral
    Start date: 2010-06-22
    End date: 2010-07-01

Lansoprazole
    Dosage: 7.5 mg, 2x/day
    Administration route: Oral
    Start date: 2010-06-28
    End date: 2010-07-28

Heparin
    Dosage: 5 iu/kg, uid/qd
    Start date: 2010-08-08
    End date: 2010-08-12

Glyceol
    Dosage: 200 ml
    Start date: 2010-06-17
    End date: 2010-06-18

Calcium Carbonate
    Dosage: 10 ml, uid/qd
    Start date: 2010-06-21
    End date: 2010-06-21

Acetaminophen
    Dosage: unk
    Start date: 2010-06-30
    End date: 2010-07-16

Ofloxacin
    Dosage: unk
    Start date: 2010-07-28
    End date: 2010-07-29

Hyalein
    Dosage: unk
    Start date: 2010-07-23
    End date: 2010-08-21



See index of all Ampicillin side effect reports >>

Drug label data at the top of this Page last updated: 2013-09-16

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