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Amphadase (Hyaluronidase) - Summary

 
 



AMPHADASE SUMMARY

Amphadase is a preparation of purified bovine testicular hyaluronidase, a protein enzyme.

Amphadase is indicated as an adjuvant to increase the absorption and dispersion of other injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous urography for improving resorption of radiopaque agents.


See all Amphadase indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Amphadase (Hyaluronidase)

Adjuvant hyaluronidase to epidural steroid improves the quality of analgesia in failed back surgery syndrome: a prospective randomized clinical trial. [2014]
STUDY DESIGN: Prospective randomized trial... CONCLUSION: We conclude that adding hyaluronidase to the epidural injectate was

Comparative pharmacokinetics and insulin action for three rapid-acting insulin analogs injected subcutaneously with and without hyaluronidase. [2013]
CONCLUSIONS: Coinjection of rHuPH20 with rapid-acting analogs accelerated insulin

Clinical trial for safety evaluation of hyaluronidase as diffusion enhancing adjuvant for infiltration analgesia of skin with lidocaine. [2012]
as a lidocaine adjuvant... CONCLUSION: The addition of hyaluronidase to lidocaine in intracutaneous

Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. [2011.05]
PURPOSE: To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis. As a secondary goal, we compared the outcomes after 30 and 60 days of treatment... CONCLUSIONS: Betamethasone Valerate 0.1%, 0.2% and 0.2% in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old. Patients initially with partial or no response can reach complete response after 60 days of treatment.

Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. [2011]
secondary goal, we compared the outcomes after 30 and 60 days of treatment... CONCLUSIONS: Betamethasone Valerate 0.1%, 0.2% and 0.2% in combination with

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Clinical Trials Related to Amphadase (Hyaluronidase)

Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage [Completed]

Evaluation of Vitrase as a Spreading Agent [Completed]
The purpose of this study is to determine whether Vitrase (hyaluronidase for injection) is effective as a spreading agent for other injected drugs prior to ocular surgery

Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP) [Completed]

Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase) [Completed]
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity to Vitrase following a single intradermal injection of 3 USP units Vitrase. Less than or equal to 10% hypersensitivity response was considered acceptable.

Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase) [Completed]
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity to Vitrase following a single intradermal injection of 3 USP units Vitrase. Less than or equal to a 10% hypersensitivity response was considered acceptable.

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Page last updated: 2014-11-30

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