NEWS HIGHLIGHTS
Published Studies Related to Amphadase (Hyaluronidase)
Clinical trial for safety evaluation of hyaluronidase as diffusion enhancing
adjuvant for infiltration analgesia of skin with lidocaine. [2012]
as a lidocaine adjuvant... CONCLUSION: The addition of hyaluronidase to lidocaine in intracutaneous
Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. [2011.05]
PURPOSE: To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis. As a secondary goal, we compared the outcomes after 30 and 60 days of treatment... CONCLUSIONS: Betamethasone Valerate 0.1%, 0.2% and 0.2% in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old. Patients initially with partial or no response can reach complete response after 60 days of treatment.
Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a
double-blind, randomized, placebo-controlled trial. [2011]
secondary goal, we compared the outcomes after 30 and 60 days of treatment... CONCLUSIONS: Betamethasone Valerate 0.1%, 0.2% and 0.2% in combination with
The role of adding hyaluronidase to fluoroscopically guided caudal steroid and hypertonic saline injection in patients with failed back surgery syndrome: a prospective, double-blinded, randomized study. [2010.11]
BACKGROUND: Failed back surgery syndrome (FBSS) has been reported to account for up to 40% of patients with chronic low back pain. Epidural fibrosis may be responsible for up to 30% of all cases of FBSS. Perineural fibrosis can interfere with cerebrospinal fluid-mediated nutrition, rendering the nerve root hyperesthetic and hypersensitive to compression. Traditionally, steroid injection has been used to treat low back pain and radiculopathy. The addition of hyaluronidase to the injectate has been reported to reduce the degree of fibrosis. AIM: To evaluate the role of hyaluronidase when added to fluoroscopically guided caudal steroid and hypertonic saline in patients with FBSS... CONCLUSION: The addition of hyaluronidase to fluoroscopically guided caudal epidural steroid and hypertonic saline combination improved long-term pain relief in patients with FBSS. (c) 2010 The Authors. Pain Practice (c) 2010 World Institute of Pain.
Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. [2010.05]
BACKGROUND & OBJECTIVES: Oral submucous fibrosis is a common premalignant condition caused by chewing arecanut and other irritants in various forms. Its medical treatment is not yet fully standardized, although the optimal doses of its medical treatment is in the form of hydrocortisone acetate combined with hyaluronidase. The problem with the prevailing treatment was injections at weekly interval. In this study we compared the efficacy of hydrocortisone acetate and hyaluronidase at weekly interval versus triamcinolone acetonide and hyaluronidase at 15 days interval... CONCLUSION: Treatment regimen of group B was more convenient to the patients because less number of visits required and cheap. No side effects were seen. A follow up study is required to see long term effects.
Clinical Trials Related to Amphadase (Hyaluronidase)
Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A) [Recruiting]
The purpose is to characterize the in-line pressure profiles associated with several
infusion technique factors during subcutaneous infusion of Lactated Ringer's solution,
preceded by recombinant human hyaluronidase (hylenex). The safety and tolerability of
hylenex-augmented subcutaneous (SC) infusion of Lactated Ringer's solution fluid is also
being evaluated.
Efficacy and Time and Resources for Hylenex-facilitated SC Rehydration Versus ORT for Dehydrated Children in the Emergency Department (ED) [Not yet recruiting]
The purpose is to evaluate the safety and efficacy as well as the time and resources needed
in the ED setting to achieve rehydration in young pediatric subjects with mild to moderate
dehydration using hylenex-facilitated SC rehydration versus oral rehydration therapy.
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