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Amoxil (Amoxicillin) - Summary

 
 



AMOXIL SUMMARY

Dual Therapy

Formulations of AMOXIL contain amoxicillin, a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms.

AMOXIL is indicated in the treatment of infections due to susceptible (ONLY (beta)-lactamase-negative) strains of the designated microorganisms in the conditions listed below:

Infections of the ear, nose, and throat --due to Streptococcus spp. ((alpha)- and (beta)-hemolytic strains only), S. pneumoniae, Staphylococcus spp., or H. influenzae.

Infections of the genitourinary tract --due to E. coli, P. mirabilis, or E. faecalis.

Infections of the skin and skin structure --due to Streptococcus spp. ((alpha)- and (beta)-hemolytic strains only), Staphylococcus spp., or E. coli.

Infections of the lower respiratory tract --due to Streptococcus spp. ((alpha)- and (beta)-hemolytic strains only), S. pneumoniae, Staphylococcus spp., or H. influenzae.

Gonorrhea, acute uncomplicated (ano-genital and urethral infections) --due to N. gonorrhoeae (males and females).

H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Triple Therapy:    AMOXIL/clarithromycin/lansoprazole

AMOXIL, in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1-year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. (See CLINICAL STUDIES and DOSAGE AND ADMINISTRATION.)

Dual Therapy:    AMOXIL/lansoprazole

AMOXIL, in combination with lansoprazole delayed-release capsules as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. (See the clarithromycin package insert, MICROBIOLOGY.) Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. (See CLINICAL STUDIES and DOSAGE AND ADMINISTRATION.)

To reduce the development of drug-resistant bacteria and maintain the effectiveness of AMOXIL and other antibacterial drugs, AMOXIL should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Indicated surgical procedures should be performed.


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NEWS HIGHLIGHTS

Media Articles Related to Amoxil (Amoxicillin)

Amoxicillin Adverse Effects Underreported, Underrecognized
Source: Medscape Infectious Diseases Headlines [2014.11.19]
Data on adverse events are missing from many clinical trial publications, according to a new systematic review.
Medscape Medical News

Amoxicillin use linked to diarrhea and thrush
Source: Respiratory / Asthma News From Medical News Today [2014.11.18]
New research has found that the frequently prescribed antibiotic amoxicillin is associated with adverse effects that could well be under-reported.

more news >>

Published Studies Related to Amoxil (Amoxicillin)

Response of feline eosinophilic plaques and lip ulcers to amoxicillin trihydrate-clavulanate potassium therapy: a randomized, double-blind placebo-controlled prospective study. [2012]
In this study, we evaluated the treatment of feline eosinophilic plaques and lip ulcers with amoxicillin trihydrate-potassium clavulanate (Clavamox(®); Pfizer Animal Health). Nineteen cats with clinical and cytological findings consistent with eosinophilic plaques and/or lip ulcers were enrolled...

Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. [2011.09]
AIM: To evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ+amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP)... CONCLUSION: The adjunctive use of MTZ+AMX offers short-term clinical and microbiological benefits, over SRP alone, in the treatment of non-smokers subjects with generalized ChP. The added benefits of MTZ were less evident. (c) 2011 John Wiley & Sons A/S.

Efficacy of amoxicillin treatment in preventing postoperative complications in patients undergoing third molar surgery: a prospective, randomized, double-blind controlled study. [2011.06]
PURPOSE: The aim of the present study was to evaluate and compare the occurrence of postoperative complications in patients receiving either pre- or postoperative amoxicillin versus placebo after third molar surgery... CONCLUSION: Amoxicillin administered pre- or postoperatively demonstrated greater efficacy than placebo in preventing postoperative complications in patients undergoing third molar surgery. The best results were obtained using the postoperative protocol. Copyright (c) 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial. [2011.06]
BACKGROUND: Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A beta -hemolytic streptococcal (GAS) pharyngitis... CONCLUSION: If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.

Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. [2011.05.07]
BACKGROUND: Researchers have suggested that antibiotics could cure acute appendicitis. We assessed the efficacy of amoxicillin plus clavulanic acid by comparison with emergency appendicectomy for treatment of patients with uncomplicated acute appendicitis... INTERPRETATION: Amoxicillin plus clavulanic acid was not non-inferior to emergency appendicectomy for treatment of acute appendicitis. Identification of predictive markers on CT scans might enable improved targeting of antibiotic treatment. FUNDING: French Ministry of Health, Programme Hospitalier de Recherche Clinique 2002. Copyright (c) 2011 Elsevier Ltd. All rights reserved.

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Clinical Trials Related to Amoxil (Amoxicillin)

A Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection [Recruiting]
The proposed study will test the hypothesis that H. pylori can be eradicated successfully (>85%) using half-or full-dose "concomitant" non-bismuth quadruple therapy regimen: rabeprazole, amoxicillin, clarithromycin and metronidazole twice daily for 7 days in patients with peptic ulcers and H. pylori related gastritis.

Two hundred patients from the outpatient department and the endoscopy unit at AUBMC will be enrolled in this open-label trial. Patients with positive CLO tests or urea breath tests, documenting H. pylori infection, will be randomized into one of two groups: Full dose or half dose the concomitant regimen, with 100 patients in each group. Compliance and side effects will be assessed, and a urea breath test will be done for all patients after 4 weeks of therapy completion to evaluate eradication rates. Success of therapy will be evaluated according to intent-to treat and per-protocol analyses.

The Effect of Amoxicillin Versus Placebo on Gastrointestinal Motility in Children [Recruiting]
The goal of this study is to determine whether amoxicillin (AMX) alone has an appreciable effect on upper gastrointestinal motility compared to placebo. In particular, induction of phase III of the interdigestive migrating motor complex (MMC) by AMX will be the primary outcome of the study. MMCs are periodic waves of electrical activity resulting in muscular contractions that pass through the walls of the stomach and intestinal tract during the fasting state. It is characterized by an initial period where there is a minimal electrical activity and muscular contraction (phase I), followed by a gradual increase in the frequency of contractions (phase III) that often leads to a characteristic cluster of contractions (phase III). This cycle occurs only in the fasting state in normal individuals and the frequency of phase III is quite varied, dependent on age and the presence of any underlying abnormalities in gastrointestinal motility. Secondary outcomes will include characteristics of the MMC, patient demographics in responders and non-responders, and the safety profile of AMX at the intervention dose.

Pediatric Taste Test Study of Cefdinir (Omnicef) Versus Amoxicillin Antibiotic Suspension Medications [Completed]
To compare the taste and smell acceptability scores of cefdinir (Omnicef) versus amoxicillin oral antibiotic suspension medications in pediatric subjects. It was designed to determine if Omnicef or amoxicillin is preferred to the other with regard to taste or smell.

A Comparative, Single-Center, Pediatric Taste Test Study of Omnicef Versus Amoxicillin Antibiotic Suspension Medications [Completed]
To compare the taste and smell acceptability scores of cefdinir (Omnicef) versus amoxicillin oral antibiotic suspension medications in pediatric subjects. It is designed to determine if Omnicef or amoxicillin is preferred to the other with regard to taste or smell.

Short Course of Amoxicillin for Erysipelas [Not yet recruiting]
The propose of this study is to determine whether a 6-day duration of oral amoxicillin treatment of erysipelas is non-inferior to a 14-day standard duration intravenous then oral amoxicillin regimen. This trial will be open but evaluation will be perform by a blind evaluator.

more trials >>

Reports of Suspected Amoxil (Amoxicillin) Side Effects

Nasopharyngitis (2)Respiratory Disorder (2)Malaise (2)Blood Pressure Increased (2)Angioedema (2)Asthenia (2)Skin Exfoliation (1)Dermatitis Bullous (1)Drug Dispensing Error (1)Vomiting (1)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 23 ratings/reviews, Amoxil has an overall score of 6.83. The effectiveness score is 7.57 and the side effect score is 7.22. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Amoxil review by care giver of 46 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   strep throat
Dosage & duration:   500 mg 3 times/daily taken by mouth for the period of 10 days
Other conditions:   fever
Other drugs taken:   none
  
Reported Results
Benefits:   the drug worked usually by the second dose. My daughter was up and around and feeling better immediatley it seemed. It had no side effects that she ever had. She could either take it on a full tomach or empty one.
Side effects:   There were no side effects that she ever had.
Comments:   I woudl give her a pill 3 times daily. She would take it right before school, right afterschool and then right before bedtime. It was easy to swallow and didn't amke her tired or sleepy, so she was able to function at school. It seemed to work tight away usually within the first day of treatment. It was great!!

 

Amoxil review by care giver of 77 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Throat infection and cough
Dosage & duration:   250mg taken 3 times a day for the period of 5 days
Other conditions:   Fever
Other drugs taken:   Cophadyl-e cough lintus and serratiopeptidase (tolpa)
  
Reported Results
Benefits:   It cleared the throat infection (painful throat when swallowing or even touching the neck) and cough significantly after 5 days, and totally cleared symptoms after 2 weeks. My 78-year-old mother could not tolerate many antibiotics. This is 1 of the few that she could take fortunately.
Side effects:   There was dry mouth, which was easily solved by taking lime juice or sour drinks.
Comments:   The treatment was easy as it involved swallowing tablets and drinking cough mixture.

 

Amoxil review by 27 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   persistent chest infection symptoms
Dosage & duration:   unknown (dosage frequency: 1/day) for the period of 2 wks req'd but quit in 3 days b/c react
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   None, presum,ably b/c I had to quit taking the drug before the prescription was completed due to side effects/ possible allergic reaction.
Side effects:   None - could not continue treatment
Comments:   Was supposed to take the drug for 2 weeks but had to stop after 3 days because of itchy rash and difiiculty breathing.

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Page last updated: 2014-11-19

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