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Amoxapine (Amoxapine) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Adverse reactions reported in controlled studies in the United States are categorized with respect to incidence below. Following this is a listing of reactions known to occur with other antidepressant drugs of this class.

Incidence Greater Than 1%

The most frequent types of adverse reactions occurring with amoxapine in controlled clinical trials were sedative and anticholinergic: these included drowsiness (14%), dry mouth (14%), constipation (12%), and blurred vision (7%).

Less frequently reported reactions are:

CNS and Neuromuscular: anxiety, insomnia, restlessness, nervousness, palpitations, tremors, confusion, excitement, nightmares, ataxia, alterations in EEG patterns.

Allergic: edema, skin rash.

Endocrine: elevation of prolactin levels.

Gastrointestinal: nausea.

Other: dizziness, headache, fatigue, weakness, excessive appetite, increased perspiration.

Incidence Less Than 1%

Anticholinergic: disturbances of accommodation, mydriasis, delayed micturition, urinary retention, nasal stuffiness.

Cardiovascular: hypotension, hypertension, syncope, tachycardia.

Allergic: drug fever, urticaria, photosensitization, pruritus, vasculitis, hepatitis.

CNS and Neuromuscular: tingling, paresthesias of the extremities, tinnitus, disorientation, seizures, hypomania, numbness, incoordination, disturbed concentration, hyperthermia, extrapyramidal symptoms, including, tardive dyskinesia. Neuroleptic malignant syndrome has been reported. (See WARNINGS .)

Hematologic: leukopenia, agranulocytosis.

Gastrointestinal: epigastric distress, vomiting, flatulence, abdominal pain, peculiar taste, diarrhea.

Endocrine: increased or decreased libido, impotence, menstrual irregularity, breast enlargement and galactorrhea in the female, syndrome of inappropriate antidiuretic hormone secretion.

Other: lacrimation, weight gain or loss, altered liver function, painful ejaculation.

Drug Relationship Unknown

The following reactions have been reported rarely, and occurred under uncontrolled circumstances where a drug relationship was difficult to assess. These observations are listed to serve as alerting information to physicians.

Anticholinergic: paralytic ileus.

Cardiovascular: atrial arrhythmias (including atrial fibrillation), myocardial infarction, stroke, heart block.

CNS and Neuromuscular: hallucinations.

Hematologic: thrombocytopenia, eosinophilia, purpura, petechiae.

Gastrointestinal: parotid swelling.

Endocrine: change in blood glucose levels.

Other: pancreatitis, hepatitis, jaundice, urinary frequency, testicular swelling, anorexia, alopecia.

Additional Adverse Reactions

The following reactions have been reported with other antidepressant drugs.

Anticholinergic: sublingual adenitis, dilation of the urinary tract.

CNS and Neuromuscular: delusions.

Gastrointestinal: stomatitis, black tongue.

Endocrine: gynecomastia.



REPORTS OF SUSPECTED AMOXAPINE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Amoxapine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Amoxapine side effects / adverse reactions in 32 year old male

Reported by a health professional (non-physician/pharmacist) from Denmark on 2011-10-11

Patient: 32 year old male

Reactions: Convulsion

Suspect drug(s):
Amoxapine

Lexapro
    Dosage: 10 mg (10 mg,1 in 1 d)
    Indication: Depression
    Start date: 2011-08-24
    End date: 2011-09-26

Other drugs received by patient: Flunitrazepam (Flunitrazepam) (Flunitrazepam); Lexotan (Bromazepam) (Tablets) (Bromazepam)



Possible Amoxapine side effects / adverse reactions in 63 year old female

Reported by a physician from Japan on 2011-10-17

Patient: 63 year old female

Reactions: Rhabdomyolysis, Blood Urea Increased, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Bradykinesia, Fall, Paralysis Flaccid, Blood Uric Acid Increased, Aspartate Aminotransferase Increased, Gait Disturbance

Suspect drug(s):
Amoxapine
    Dosage: 20 mg, 3x/day
    Administration route: Oral
    Indication: Lung Neoplasm Malignant
    Start date: 2010-09-22

Lipitor
    Dosage: 10 mg, 1x/day
    Administration route: Oral
    Indication: Hyperlipidaemia
    Start date: 2010-03-10

Other drugs received by patient: Grandaxin; Adalat; Sepazon; Aspirin; Lansoprazole; Rize



Possible Amoxapine side effects / adverse reactions in 26 year old male

Reported by a physician from Japan on 2011-10-28

Patient: 26 year old male

Reactions: Intraocular Pressure Increased

Suspect drug(s):
Amoxapine
    Indication: Depression

Zoloft
    Indication: Depression



See index of all Amoxapine side effect reports >>

Drug label data at the top of this Page last updated: 2008-10-28

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