AMINOPHYLLINE SUMMARY
AMINOPHYLLINE
Injection, USP
Aminophylline Injection, USP is a sterile, nonpyrogenic solution of aminophylline in water for injection. Aminophylline (dihydrate) is approximately 79% of anhydrous theophylline by weight. Aminophylline Injection is administered by slow intravenous injection or diluted and administered by intravenous infusion. The solution contains no bacteriostat or antimicrobial agent and is intended for use only as a single-dose injection. When smaller doses are required the unused portion should be discarded. Aminophylline is a 2:1 complex of theophylline and ethylenediamine. Theophylline is structurally classified as a methylxanthine. Aminophylline occurs as a white or slightly yellowish granule or powder, with a slight ammoniacal odor. Aminophylline has the chemical name 1H-Purine-2, 6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-ethanediamine (2:1).
Intravenous theophylline is indicated as an adjunct to inhaled beta-2 selective agonists and systemically administered corticosteroids for the treatment of acute exacerbations of the symptoms and reversible airflow obstruction associated with asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.
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NEWS HIGHLIGHTS
Published Studies Related to Aminophylline
The effects of aminophylline on bispectral index during inhalational and total intravenous anaesthesia. [2008.06]
Aminophylline is usually used during anaesthesia to treat bronchospasm but recent findings suggest that it can also be used to shorten recovery time after general anaesthesia. However, it is unclear whether aminophylline shows similar properties during a steady-state phase of deep surgical anaesthesia...
Early administration of two intravenous bolus of aminophylline added to the standard treatment of children with acute asthma. [2008.01]
OBJECTIVES: Evaluate the efficacy of adding two intravenous bolus of aminophylline to the standard treatment of acute asthma episode in children admitted to the pediatric emergency room (PER)... CONCLUSION: In children aged 2-5 years admitted to a PER with asthma, two intravenous doses of 5mg/kg of aminophylline given 6h apart did not change the length of stay in hospital, the number of nebulizations given or the duration of oxygen therapy required. We are unable to tell whether there would be benefit with higher doses of aminophylline designed to give levels in the usual therapeutic range.
Early administration of two intravenous bolus of aminophylline added to the standard treatment of children with acute asthma. [2008.01]
OBJECTIVES: Evaluate the efficacy of adding two intravenous bolus of aminophylline to the standard treatment of acute asthma episode in children admitted to the pediatric emergency room (PER)... CONCLUSION: In children aged 2-5 years admitted to a PER with asthma, two intravenous doses of 5mg/kg of aminophylline given 6h apart did not change the length of stay in hospital, the number of nebulizations given or the duration of oxygen therapy required. We are unable to tell whether there would be benefit with higher doses of aminophylline designed to give levels in the usual therapeutic range.
The effect of aminophylline on renal colic: a randomized double blind controlled trial. [2007.11]
OBJECTIVE: To evaluate the efficacy of aminophylline infusion as a painkiller compared with placebo in patients with acute renal colic... CONCLUSION: This prospective study provides remarkable information about the efficacy of aminophylline on pain relief and decreasing narcotic usage in symptomatic urinary calculi. It is safe, inexpensive, with minute side effects and can be considered a good alternative or additive to narcotic analgesics in the management of renal colic.
Early administration of two intravenous bolus of aminophylline added to the standard treatment of children with acute asthma. [2007.09.13]
OBJECTIVES: Evaluate the efficacy of adding two intravenous bolus of aminophylline to the standard treatment of acute asthma episode in children admitted to the pediatric emergency room (PER)... CONCLUSION: In children aged 2-5 years admitted to a PER with asthma, two intravenous doses of 5mg/kg of aminophylline given 6h apart did not change the length of stay in hospital, the number of nebulizations given or the duration of oxygen therapy required. We are unable to tell whether there would be benefit with higher doses of aminophylline designed to give levels in the usual therapeutic range.
Clinical Trials Related to Aminophylline
Aminophylline in Bradyasystolic Cardiac Arrest [Completed]
The purpose of this study is to evaluate the effect of aminophylline in patients with
out-of-hospital bradyasystolic cardiac arrest.
Study of MK0476 in Adult Patients With Acute Asthma [Active, not recruiting]
The study estimates the efficacy and safety of MK0476 and aminophylline intravenous
administration in adult patients with acute asthma.
Common Neonatal Procedures Could Affect the aEEG in <30 Weeks of Gestational Age Preterms [Not yet recruiting]
Very low birth weight infants has increased dramatically their survival. Survival without
neurologic disturbance varies a lot between centers. There is evidence that fluctuations in
cerebral blood flow influences the appearance of intraventricular hemorrhage and itself
implies a detrimental neurologic developing. The electroencephalography is the result of
electric base membrane activity on rest, and it's influenced by the blood flow either. The
Amplitude-integrated electroencephalography is a novel tool, that is capable to be
continuously used at the patient bed and is easily to be read by the trained clinician. The
hypothesis is that common procedures as Surfactant instilation, Indomethacin and
Aminophyline infusion as the appearance of apneas alters the aEEG register. It is a
prospective study that tries to recruit 10 < 30 weeks of gestational age with aprofen
consent to monitorize the aEEG since birth to the seventh day of live.
Differentiation Induction in Acute Myelogenous Leukemia [Recruiting]
Hypothesis: Differentiation induction therapy in acute myelogenous leukemia (AML) can be used
to achieve disease control and stabilize peripheral blood counts in patients with acute
myelogenous leukemia.
Adult patients (<18 years of age) who can be included: Elderly patients (>60 years of age)
with newly diagnosed AML who cannot achieve standard chemotherapy, patients with relapsed or
resistant AML. Patients with relapsed or resistant AML who cannot receive intensive
chemotherapy.
Treatment: Patients will be treated with all-trans retinoic acid (oral administration),
valproic acid (7 days intravenous administration and later oral administration)and
theophyllamine (7 days intravenous administration and later oral administration). Duration of
treatment at least 2 months or until disease progression. Maximal duration of treatment 2
years.
Followup: Clinical evaluation, peripheral blood samples, bone marrow samples.
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