Aminohippurate sodium* is an agent to measure effective renal plasma flow (ERPF). It is the sodium salt of para-aminohippuric acid, commonly abbreviated "PAH."It is water soluble, lipid-insoluble, and has a pKa of 3.83.
Estimation of effective renal plasma flow.
Measurement of the functional capacity of the renal tubular secretory mechanism.
Published Studies Related to Aminohippurate
Effects of tenoxicam on renal function and the disposition of inulin and p-aminohippurate in healthy volunteers and patients with chronic renal failure. [1991.10]
1. The effects of tenoxicam on renal function were studied in 10 patients with chronic renal failure (creatinine clearance 46.7 +/- 11.9 ml min-1 1.73 m-2) and eight healthy volunteers... The administration of tenoxicam for 10 days was associated with a small but significant increase in the plasma half-life and volume of distribution of inulin.(ABSTRACT TRUNCATED AT 250 WORDS).
Clinical Trials Related to Aminohippurate
A Study to Evaluate the Effect of GSK1349572 on Iohexol and Para-Aminohippurate Clearance in Healthy Subjects [Not yet recruiting]
The current study is designed to confirm the mechanism behind the increase in serum
creatinine observed during GSK1349572 therapy; specifically, the study will determine
whether GSK1349572 has any effect on glomerular filtration rate (GFR) or effective renal
plasma flow. Absent such effects, one may conclude that the small increases in serum
creatinine observed are due to the inhibition of the tubular secretion of creatinine via
organic cation transporter 2 (OCT2) consistent with in vitro data. .
Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers [Not yet recruiting]
In this study the gender specificity of the effects of furosemide in female and male
volunteers will be investigated. The healthy volunteers receive 1. furosemide and 2.
aminohippurate sodium "PAH" as single dose. The main objective is gender-specific comparison
of the pharmacokinetic parameters of furosemide in relation to the effect of furosemide
(urinary excretion). Secondary objectives are the gender-specific comparison of renal and
systemic PAH clearance with the clearance of furosemide and the influence of various genetic
polymorphisms on the variability of furosemide pharmacokinetics.
Measurement of Kidney Blood Flow and Oxygen Levels by MRI [Recruiting]
The traditional measurement of renal blood flow involves the collection of multiple blood
and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In
this study, the investigators determine the ability of MRI to measure renal blood flow. The
primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal
blood flow as measured by MRI.
Determination of Kidney Function [Recruiting]
Much more about kidney disorders can be learned by determining kidney function. This
research proposes to study the kidneys function by several parameters known as glomerular
filtration rate (GFR), Renal Plasma Flow (RPF), and Glomerular Capillary Wall
The study will select patients suffering from different types of kidney diseases. These
patients will be selected based on the presence of significant amounts of protein in their
Standard blood and urine tests are often unable to provide completely accurate information
about the kidney. In order for researchers to have a more accurate idea of kidney function,
they will use alternative tests. Test materials (para aminohippurate and inulin) will be
injected into patients veins that provides information based on their filtration through the
Renogram Study With Percutaneous Nephrolithotomy (PERC): Alterations in Renal Blood Flow as a Consequence of PERC [Recruiting]
Patients with large or otherwise complex renal calculi are commonly treated by percutaneous
nephrolithotomy (PNL; PERC). PERC requires the creation of an approximately 10 mm channel
through the renal parenchyma, into the intra-renal collecting system, in order to effect
stone fragmentation and extraction. Although the nephrostomy tract is confined to a small
fraction of the renal parenchyma (approximately 1%), the trauma associated with the creation
of the tract will affect blood flow and oxygen delivery to regions beyond the immediate site
of injury. It is possible that this could result in a significant functional renal
impairment. There are several reports describing the effect of PERC on renal function, but
interpretation of these studies is difficult, due to a lack of uniformity in patient
selection and variability in the timing of peri-operative evaluation. Recent data from the
investigators' lab, obtained from a porcine model, suggest that, acutely, PERC causes a
significant decrease in renal function as measured by para amino hippurate (PAH) clearance.
The purpose of this study is to determine, in a rigorous and standardized fashion, the acute
effects of PERC on renal function, as measured by nuclear renography.