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Aminocaproic Acid (Aminocaproic Acid) - Summary

 

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SUMMARY

AMINOCAPROIC ACID
INJECTION, USP

Aminocaproic Acid Injection, USP is 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.

Aminocaproic Acid (aminocaproic acid) is indicated for the following:

Aminocaproic acid is useful in enhancing hemostasis when fibrinolysis contributes to bleeding. In life-threatening situations, fresh whole blood transfusions, fibrinogen infusions, and other emergency measures may be required.

Fibrinolytic bleeding may frequently be associated with surgical complications following heart surgery (with or without cardiac bypass procedures) and portacaval shunt; hematological disorders such as aplastic anemia; abruptio placentae; hepatic cirrhosis; neoplastic disease such as carcinoma of the prostate, lung, stomach, and cervix.

Urinary fibrinolysis, usually a normal physiological phenomenon, may frequently be associated with life-threatening complications following severe trauma, anoxia, and shock. Symptomatic of such complications is surgical hematuria (following prostatectomy and nephrectomy) or nonsurgical hematuria (accompanying polycystic or neoplastic diseases of the genitourinary system). (See WARNINGS.)

NEWS HIGHLIGHTS RELATED TO AMINOCAPROIC ACID

Published Studies Related to Aminocaproic Acid

Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. [2006.05]

A double-blind, placebo-controlled trial of epsilon-aminocaproic Acid for reducing blood loss in coronary artery bypass grafting surgery. [2006.02]

Aprotinin and epsilon aminocaproic acid are effective in reducing blood loss after primary total hip arthroplasty--a prospective randomized double-blind placebo-controlled study. [2005.07]

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Clinical Trials Related to Aminocaproic Acid

Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery [Active, not recruiting]

Bradykinin Receptor Antagonism During Cardiopulmonary Bypass- Specific Aim 3 [Recruiting]

Platelet Function And Aggregometry In Patients With Aortic Valve Stenosis [Recruiting]

Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta. [Recruiting]

Effects of Aprotinin During Cardiac Surgery/Long Term Death Rates [Active, not recruiting]

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Page last updated: 2006-11-04

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