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Amidate (Etomidate) - Summary



Amidate (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0). It is intended for the induction of general anesthesia by intravenous injection.

Etomidate is indicated by intravenous injection for the induction of general anesthesia. When considering use of etomidate, the usefulness of its hemodynamic properties (see CLINICAL PHARMACOLOGY) should be weighed against the high frequency of transient skeletal muscle movements (see ADVERSE REACTIONS).

Intravenous etomidate is also indicated for the supplementation of subpotent anesthetic agents, such as nitrous oxide in oxygen, during maintenance of anesthesia for short operative procedures such as dilation and curettage or cervical conization.

See all Amidate indications & dosage >>


Media Articles Related to Amidate (Etomidate)

The Evaluation of Clinical Superiority in Anesthesia Trials
Source: Medscape Anesthesiology Headlines [2016.10.19]
The authors propose a cognitive forcing strategy to avoid the pitfall of making judgments about the clinical superiority of an intervention on the basis of statistical significance alone.
British Journal of Anaesthesia

Transcarotid TAVR May Often Avoid General Anesthesia
Source: theheart.org | Medscape Cardiology Headlines [2016.10.18]
Using local anesthesia with conscious sedation might have cut the risk of periprocedural strokes a small transcarotid-TAVR series; the patients had severe peripheral vascular disease.
Heartwire from Medscape

Transcarotid TAVR Safer Under Local Anesthesia
Source: MedPage Today Nephrology [2016.10.17]
(MedPage Today) -- Early events only seen in general anesthesia cases in French series

Postoperative Delirium, Cognitive Changes Theme of ASA 2016
Source: Medscape Anesthesiology Headlines [2016.10.21]
New data from major clinical trials, the effect of anesthesia on the brain, and chronic opioid use will be addressed at Anesthesiology 2016.
Medscape Medical News

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Published Studies Related to Amidate (Etomidate)

Dezocine pretreatment prevents myoclonus induced by etomidate: a randomized, double-blinded controlled trial. [2015]
The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dezocine on the incidence and severity of myoclonus induced by etomidate. Patients (108) were randomly assigned to one of two groups to receive either 0.1 mg kg(-1) of dezocine (n = 54; Group D) or saline (n = 54; Group S) intravenously 1 min before 0.3 mg kg(-1) etomidate was given...

Ondansetron reducing pain on injection of etomidate: a controlled randomized study. [2014]
of etomidate... CONCLUSION: This study illustrates that pre-treatment with intravenous

Effect of etomidate versus thiopental on major depressive disorder in electroconvulsive therapy, a randomized double-blind controlled clinical trial. [2012]
sodium thiopental on the depression symptoms in patients who have received ECT... CONCLUSIONS: In conclusion, etomidate may improve major depressive disorder more

Effect of Etomidate Versus Thiopental on Major Depressive Disorder in Electroconvulsive Therapy, a Randomized Double-Blind Controlled Clinical Trial. [2011.10.06]
BACKGROUND:: Although the therapeutic effect of electroconvulsive therapy (ECT) on major depressive disorder is widely investigated, there is a gap in literature regarding the possible effects of the medications used for induction of anesthesia in ECT. To the best of the authors' knowledge, this study is the first randomized double-blind clinical trial comparing the effect of etomidate and sodium thiopental on the depression symptoms in patients who have received ECT... CONCLUSIONS:: In conclusion, etomidate may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT.

Haemodynamic consequences of etomidate administration in elective cardiac surgery: a randomized double-blinded study. [2011.10]
BACKGROUND: The consequences of inhibition of cortisol synthesis by a single dose of etomidate on subsequent vasopressor drug usage and the duration of relative adrenal insufficiency (RAI) after cardiac surgery are not known... CONCLUSIONS: A single bolus of etomidate blunts the hypothalamic-pituitary-adrenal axis response for more than 24 h in patients undergoing elective cardiac surgery, but this was not associated with an increase in vasopressor requirements.

more studies >>

Clinical Trials Related to Amidate (Etomidate)

Etomidate vs. Midazolam for Sedation During ERCP [Completed]
Recently up-coming drug, etomidate which is a modulator of GABA(gamma-Aminobutyric acid)-A receptor has been known that it maintains the appropriate sedative levels and affects little effects on respiratory system. The investigators are now trying to investigate that etomidate with meperidine combination regimen is superior to the midazolam with meperidine more effective and less harm on sedation during the ERCP procedure.

Ketamine Versus Etomidate for Rapid Sequence Intubation [Suspended]

Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions [Completed]
There are multiple retrospective studies detailing the use of etomidate in pediatric procedural sedation but few to no prospective clinical trials. None have compared etomidate to ketamine, currently the most commonly used sedative in the emergency department for pediatric procedural sedation. The investigators propose a randomized, controlled trial comparing etomidate versus ketamine for procedural sedation for fracture reduction for children presenting with extremity fracture requiring sedation for reduction. The investigators hypothesize that etomidate in combination with fentanyl will have similar reduction of distress and procedural recall as ketamine in combination with midazolam.

Single Dose of Etomidate and Adrenal Cortex [Completed]
we aim to evaluate the effects of single dose of etomidate or use of steroid prior to etomidate during emergency intubation on hemodynamics and adrenal cortex.

A Dose-response Study of Lidocaine and Etomidate [Completed]

more trials >>

Page last updated: 2016-10-21

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