Media Articles Related to Amidate (Etomidate)
Are the cognitive side effects of anesthesia overlooked?
Source: Medical Devices / Diagnostics News From Medical News Today [2014.08.19]
Although guidelines are commonly in place to minimize pain-related side effects of anesthesia, a new survey finds that less attention is paid to the risk of cognitive side effects.
For pediatric knee surgery, regional anesthesia reduces pain, speeds recovery
Source: Bones / Orthopedics News From Medical News Today [2014.08.14]
A recent study of an ultrasound-guided regional anesthesia technique, called femoral nerve block, shows that it leads to less opioid use and allows the majority of patients to go home within hours of...
Dopamine release from ventral tegmental area may help speed emergence from anesthesia, avoid complications
Source: Pain / Anesthetics News From Medical News Today [2014.07.31]
Stimulating one of two dopamine-producing regions in the brain was able to arouse animals receiving general anesthesia with either isoflurane or propofol.
The disruptive effects of anesthesia on brain cell connections are likely temporary
Source: Pain / Anesthetics News From Medical News Today [2014.07.30]
A study of juvenile rat brain cells suggests that the effects of a commonly used anesthetic drug on the connections between brain cells are temporary.
'Ramp control' algorithm simplifies preoperative test for patients with severe sleep apnea
Source: Pain / Anesthetics News From Medical News Today [2014.08.01]
New anesthesia technique helps show cause of obstruction in sleep apneaA simplified anesthesia procedure may enable more widespread use of preoperative testing to demonstrate the cause of airway...
Published Studies Related to Amidate (Etomidate)
Effect of etomidate versus thiopental on major depressive disorder in
electroconvulsive therapy, a randomized double-blind controlled clinical trial. 
sodium thiopental on the depression symptoms in patients who have received ECT... CONCLUSIONS: In conclusion, etomidate may improve major depressive disorder more
Effect of Etomidate Versus Thiopental on Major Depressive Disorder in Electroconvulsive Therapy, a Randomized Double-Blind Controlled Clinical Trial. [2011.10.06]
BACKGROUND:: Although the therapeutic effect of electroconvulsive therapy (ECT) on major depressive disorder is widely investigated, there is a gap in literature regarding the possible effects of the medications used for induction of anesthesia in ECT. To the best of the authors' knowledge, this study is the first randomized double-blind clinical trial comparing the effect of etomidate and sodium thiopental on the depression symptoms in patients who have received ECT... CONCLUSIONS:: In conclusion, etomidate may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT.
Haemodynamic consequences of etomidate administration in elective cardiac surgery: a randomized double-blinded study. [2011.10]
BACKGROUND: The consequences of inhibition of cortisol synthesis by a single dose of etomidate on subsequent vasopressor drug usage and the duration of relative adrenal insufficiency (RAI) after cardiac surgery are not known... CONCLUSIONS: A single bolus of etomidate blunts the hypothalamic-pituitary-adrenal axis response for more than 24 h in patients undergoing elective cardiac surgery, but this was not associated with an increase in vasopressor requirements.
Corticosteroid after etomidate in critically ill patients: A randomized controlled trial. [2011.09.15]
OBJECTIVE:: To investigate the effects of moderate-dose hydrocortisone on hemodynamic status in critically ill patients throughout the period of etomidate-related adrenal insufficiency... CONCLUSION:: These findings suggest that critically ill patients without septic shock do not benefit from moderate-dose hydrocortisone administered to overcome etomidate-related adrenal insufficiency.
Effect of a small priming dose on myoclonic movements after intravenous anaesthesia induction with Etomidate-Lipuro in children. [2011.08]
BACKGROUND: In children, the incidence of injection pain at i.v. anaesthetic induction with Etomidate-Lipuro is low when compared with propofol mixed with lidocaine (5%). However, the incidence of involuntary myoclonic movements (MM) after induction of anaesthesia is higher compared with propofol (85% vs. 15%). In adults, the incidence of MM is reported to be significantly reduced if a small priming dose is administered immediately before the main injection of etomidate. The aim of this prospective, randomized, double-blind, placebo-controlled clinical trial was to investigate if a small priming dose of etomidate effectively can reduce the incidence of MM also in children... CONCLUSIONS: Children in the age range of 5-10 yr appear to be especially prone to react with involuntary MM after i.v. induction of anaesthesia with etomidate. The use of a small, non-sedative, priming dose did not influence the incidence of involuntary MM after i.v. induction of anaesthesia with etomidate in children 1-15 yr of age.
Clinical Trials Related to Amidate (Etomidate)
Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone? [Not yet recruiting]
This study will attempt to show that a combination of drugs, Etomidate and Propofol, provide
a more stable blood pressure when used to put elderly hypertensive patients to sleep than
either drug used alone.
The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone [Recruiting]
During induction for cardiac surgery, patient hemodynamic stability is achieved by using
anesthetic drugs which least affects hemodynamics such as benzodiazepines, etomidate.
Etomidate although has been used for a long time but its safety regarding cortisol synthesis
suppression is still doubtful. This study measures the changes in cortisol levels during
cardiac surgery with the use of cardiopulmonary bypass by comparison between two inductive
agents (etomidate and thiopentone). Recording data also include hemodynamic changes during
induction, inotropic use for coming of cardiopulmonary bypass, blood glucose levels, amount
of insulin usage, length of ICU and hospital saty.
Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions [Recruiting]
There are multiple retrospective studies detailing the use of etomidate in pediatric
procedural sedation but few to no prospective clinical trials. None have compared etomidate
to ketamine, currently the most commonly used sedative in the emergency department for
pediatric procedural sedation. We propose a randomized, controlled trial comparing etomidate
versus ketamine for procedural sedation for fracture reduction for children presenting with
extremity fracture requiring sedation for reduction. We hypothesize that etomidate in
combination with fentanyl will have similar reduction of distress and procedural recall as
ketamine in combination with midazolam.
The Effect of Etomidate on Patient Outcomes After Single Bolus Doses [Recruiting]
The primary aim is to determine the difference in hospital length of stay between septic
patients given etomidate and those given midazolam for induction during rapid sequence
intubation (RSI) in the emergency department. To achieve this aim we plan to perform a
prospective randomized trial measuring the length of stay of patients meeting sepsis
criteria and requiring intubation. The investigators will compare in-hospital mortality
rates between patients given etomidate and patients given midazolam for induction. In
addition to hospital length of stay, secondary endpoints between the two groups will include
length of stay in the intensive care unit, death within 48 hours of admission, and total
number of days intubated.
In adult patients presenting to the emergency department with sepsis and requiring rapid
sequence intubation, the length of stay of patients given etomidate will be greater than
that of patients given the alternative agent midazolam for induction.
The Effect of Etomidate on Outcomes of Trauma Patients [Not yet recruiting]
Rationale: The drug etomidate causes increased mortality if used for continuous sedation in
mechanically ventilated patients; however, etomidate continues to be widely used as a
single-bolus induction agent for endotracheal intubation because of its favorable
hemodynamic properties. Recent data have raised questions regarding the safety of using
etomidate for even a single bolus in patients at risk of adrenal insufficiency, emphasizing
the fact that single bolus doses of etomidate cause measurable adrenal suppression, and
consequently may cause increases in vasopressor requirements and in hospital length of stay.
Alternative FDA-approved induction agents, such as midazolam, may be safer than etomidate;
however, no studies have formally compared these agents.
Research Hypothesis: The investigators hypothesize that in critically ill trauma patients
presenting to the emergency department requiring rapid sequence intubation, the hospital
length of stay for patients given etomidate will be greater than for patients given
midazolam for induction.
Specific Aims: The specific aim is to determine the difference in hospital length of stay
between trauma patients given etomidate and those given midazolam for induction during rapid
sequence intubation in the emergency department. The investigators plan to compare the two
groups in terms of hospital length of hospital stay, length of stay in the intensive care
unit, and duration of intubation by performing a prospective, randomized, trial of
critically ill trauma patients presenting to the emergency department requiring intubation.
The investigators will also compare the mortality rates in these two groups while
controlling for severity of illness and the use of steroids while hospitalized.
Significance: If the use of etomidate to induce anesthesia prior to intubation adversely
affects the hospital length of stay of trauma patients, this length of stay might be reduced
in such patients by using alternative agents for induction. Since etomidate is currently in
widespread use as an induction agent, the results of this study could have significant
implications for patient management.