Amicar (Aminocaproic Acid) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

AMICAR is generally well tolerated. The following adverse experiences have been reported:

General: Edema, headache, malaise.

Hypersensitivity Reactions: Allergic and anaphylactoid reactions, anaphylaxis.

Cardiovascular: Bradycardia, hypotension, peripheral ischemia, thrombosis.

Gastrointestinal: Abdominal pain, diarrhea, nausea, vomiting.

Hematologic: Agranulocytosis, coagulation disorder, leukopenia, thrombocytopenia.

Musculoskeletal: CPK increased, muscle weakness, myalgia, myopathy (see WARNINGS), myositis, rhabdomyolysis.

Neurologic: Confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope.

Respiratory: Dyspnea, nasal congestion, pulmonary embolism.

Skin: Pruritis, rash.

Special Senses: Tinnitus, vision decreased, watery eyes.

Urogenital: BUN increased, renal failure. There have been some reports of dry ejaculation during the period of AMICAR treatment. These have been reported to date only in hemophilia patients who received the drug after undergoing dental surgical procedures. However, this symptom resolved in all patients within 24 to 48 hours of completion of therapy.

REPORTS OF SUSPECTED AMICAR SIDE EFFECTS / ADVERSE REACTIONS

Possible Amicar side effects / adverse reactions in 75 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-15

Patient: 75 year old male weighing 73.5 kg (161.7 pounds)

Reactions: Gastrointestinal Haemorrhage, Condition Aggravated, Thrombocytopenia, Cardiac Arrest, Haemodynamic Instability

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Placebo
    Dosage: 0.5 mg;qd;po
    Administration route: Oral
    Indication: Myelofibrosis
    Start date: 2012-04-13
    End date: 2012-04-13

Placebo
    Dosage: 0.5 mg;qd;po
    Administration route: Oral
    Indication: Myelofibrosis
    Start date: 2011-06-22

Amicar
    Dosage: ; po
    Administration route: Oral
    Indication: Gingival Bleeding
    Start date: 2012-04-12

Other drugs received by patient: Acetaminophen; Magic Mouthwash; Allopurinol; Irbesartan; Melatonin; Vitamin D; Ambien; Glyburide; Metformin HCL; Metamucil-2; Mineral OIL; Aspirin

Possible Amicar side effects / adverse reactions in 60 year old female

Reported by a physician from United States on 2012-06-22

Patient: 60 year old female

Reactions: Hyperkalaemia, PO2 Increased

Suspect drug(s):
Amicar
    Dosage: (1.0 gram/hour),intravenous

Amicar
    Dosage: (10 gram,once),intravenous bolus
    Indication: Haemorrhage

Other drugs received by patient: Clonidine; NPH Insulin; Erythropoietin (Erythropoietin); Allopurinol; Lisinopril; Colchicine; Famotidine; Atenolol; Prednisone TAB; Desmopressin Acetate; Metoclopramide; Hydrocortone; Coumadin

Possible Amicar side effects / adverse reactions in 60 year old female

Reported by a consumer/non-health professional from United States on 2012-06-29

Patient: 60 year old female weighing 108.9 kg (239.5 pounds)

Reactions: Vomiting, Haemorrhage, Nausea, Condition Aggravated, Headache, Eczema, Epistaxis

Suspect drug(s):
Diflorasone Diacetate
    Indication: Product Used FOR Unknown Indication

Lysteda
    Indication: Platelet Disorder

Polymyxin B Sulfate
    Indication: Product Used FOR Unknown Indication

Carafate
    Indication: Product Used FOR Unknown Indication

Metronidazole
    Administration route: Topical
    Indication: Product Used FOR Unknown Indication

Fluticasone Propionate
    Indication: Product Used FOR Unknown Indication
    End date: 2012-04-01

Desonide
    Indication: Product Used FOR Unknown Indication

Lidocaine
    Indication: Product Used FOR Unknown Indication

Vitamin E
    Indication: Product Used FOR Unknown Indication

Amicar
    Indication: Product Used FOR Unknown Indication

Tretinoin
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Acetaminophen