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Americaine (Benzocaine) - Description and Clinical Pharmacology



AMERICAINE Anesthetic Lubricant contains benzocaine 20% with benzethonium chloride 0.1% as a preservative in a water soluble base of polyethylene glycol 300 and 3350.

Benzocaine, a local anesthetic, is chemically ethyl p   -aminobenzoate, C9 H11 NO2, with a molecular weight of 165.19 and has the following structural formula:


Benzocaine reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

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