Media Articles Related to Americaine (Benzocaine)
The Evaluation of Clinical Superiority in Anesthesia Trials
Source: Medscape Anesthesiology Headlines [2016.10.19]
The authors propose a cognitive forcing strategy to avoid the pitfall of making judgments about the clinical superiority of an intervention on the basis of statistical significance alone.
British Journal of Anaesthesia
Transcarotid TAVR May Often Avoid General Anesthesia
Source: theheart.org | Medscape Cardiology Headlines [2016.10.18]
Using local anesthesia with conscious sedation might have cut the risk of periprocedural strokes a small transcarotid-TAVR series; the patients had severe peripheral vascular disease.
Heartwire from Medscape
Transcarotid TAVR Safer Under Local Anesthesia
Source: MedPage Today Nephrology [2016.10.17]
(MedPage Today) -- Early events only seen in general anesthesia cases in French series
Postoperative Delirium, Cognitive Changes Theme of ASA 2016
Source: Medscape Anesthesiology Headlines [2016.10.21]
New data from major clinical trials, the effect of anesthesia on the brain, and chronic opioid use will be addressed at Anesthesiology 2016.
Medscape Medical News
Published Studies Related to Americaine (Benzocaine)
Efficacy of Benzocaine 20% Topical Anesthetic Compared to Placebo Prior to
Administration of Local Anesthesia in the Oral Cavity: A Randomized Controlled
The aim of the present study was to compare the effects of a topical anesthetic
to a placebo on pain perception during administration of local anesthesia in 2
regions of the oral cavity. A split-mouth, double-blind, randomized clinical
trial design was used...
Double-blind comparison of two types of benzocaine lozenges for the treatment of acute pharyngitis. 
In a reference-controlled double-blind trial in patients with acute pharyngitis the effects of a newly developed lozenge containing 8 mg of benzocaine (p-aminobenzoic acid ethyl ester, CAS 94-09-7) were compared with those of an identically dosed commercial pastille... The application of the benzocaine lozenges was statistically non-inferior to the use of the pastilles.
Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine. [2009.09]
PURPOSE: The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children... CONCLUSIONS: Application of Oraqix did not reduce discomfort when compared to benzocaine in this small sample size. Oraqix was more effective than benzocaine in the age group 9 and older. A larger sample size is needed to determine its efficacy in children younger than 9years old.
A study of benzocaine gel dosing for toothache. 
CONCLUSION: The improved dosing directions resulted in a high percentage of subjects self-applying an appropriate amount of benzocaine gel or matching placebo. The label and study methodology appear suitable for a pivotal dose-response study in subjects with toothache pain. While the current study was not statistically powered to make firm efficacy conclusions, 20% benzocaine gel appeared more efficacious than placebo, providing a rapid onset of pain relief and a relatively long duration of action.
Prospective randomized study of viscous lidocaine versus benzocaine in a GI cocktail for dyspepsia. [2004.07]
We hypothesized that Benzocaine (Hurricaine) would work as quickly and effectively as viscous Lidocaine in this preparation. This was a prospective randomized, single-blinded comparison between Benzocaine and Lidocaine as the topical anesthetic in a gastrointestinal (GI) cocktail... There were no adverse outcomes in either group.
Clinical Trials Related to Americaine (Benzocaine)
Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel [Recruiting]
The project is a study comparing the effectiveness of two topical anesthetics for control of
pain associated with dental needle insertion in the palatal mucosa. A standard dental
topical anesthetic (20% benzocaine) will serve as an "active" control and will be compared
to a combination topical anesthetic, consisting of 20% lidocaine, 4% tetracaine and 2%
phenylephrine (TAC Alternate Gel, Compounding Arts Pharmacy, Lafayette, LA).
Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis [Recruiting]
This project will be a double blind study comparing the efficacy of two different topical
anesthetics used to reduce the pain associated with insertion of dental needles on the
palatal mucosa. The two topical anesthetics being compared are 20% Benzocaine, and Pliaglis.
In order to complete a number of different dental procedures it is often necessary to
provide local anesthesia of the palate. Intraoral injections into the palatal mucosa are
often uncomfortable and even painful. In an effort to increase patient comfort, a topical
anesthetic is often used prior to the injection. Test subjects undergoing routine endodontic
treatment on maxillary teeth will have a 27- gauge dental needle inserted into the mucosa of
the hard palate as part of the initial step in standard local anesthetic injection. At the
injection site and prior to the needle stick, the mucosa will be topically anesthetized by
using one of the two different test compounds (Benzocaine or Pliaglis). After the injection
patients will be asked to score the level of discomfort associated with the needle stick.
The purpose of the project is to determine if there is a clinical difference in the level of
pain felt upon needle stick, between the two different topical anesthetics.
Benzocaine Versus Placebo Spray for Pain Relief at Hysterosalpingogram [Completed]
Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn [Terminated]
Frenotomy of tongue-tie is commonly performed to resolve breastfeeding difficulties, eg
maternal nipple pain and infant's latching difficulties. The procedure carries minor
discomfort for the infants. It is not known whether the use of topical benzocaine, a very
bitter tasting material' applied to the tongue-tie would decrease the length of cry. We will
measure the duration of crying in infants treated with topical benzocaine to the duration in
those not treated with the mediation.
Benzocaine Gel Toothache Dose-Response Study [Completed]
To evaluate the efficacy and safety of benzocaine gel products for the relief of toothache
and to assess the subject's compliance with proposed label directions.