Media Articles Related to Americaine (Benzocaine)
FDA Issues Class 1 Recall of Defective Anesthesia Products
Source: Medscape Anesthesiology Headlines [2013.11.26]
The US FDA has issued a Class 1 Recall of anesthesia products that provide respiratory support to patients due to a potential defect that may cause serious adverse health concerns, including death.
Anesthesia Technique May Affect Survival After Breast Cancer Surgery: Study
Source: MedicineNet Breast Specialty [2013.10.15]
Title: Anesthesia Technique May Affect Survival After Breast Cancer Surgery: Study
Category: OnHealth Staging
Created: 10/15/2013 4:36:00 PM
Last Editorial Review: 10/15/2013 4:35:43 PM
Anesthesia May Harm Children's Brains
Source: MedicineNet Ear Tubes Specialty [2012.08.20]
Title: Anesthesia May Harm Children's Brains
Category: Health News
Created: 8/20/2012 11:00:00 AM
Last Editorial Review: 8/20/2012 12:00:00 AM
The effect of propofol on the sciatic nerve
Source: Pain / Anesthetics News From Medical News Today [2013.11.05]
Propofol is a rapid, but short-acting, intravenous drug that is preferentially used for the induction and maintenance of anesthesia. Propofol can inhibit inflammation and suppress the secretion of the proinflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor alpha from astrocytes, and enhance the synthesis and release of the anti-inflammatory cytokine interleukin-10.
Local anesthetic injected in neck reduces severe hot flashes
Source: Pain / Anesthetics News From Medical News Today [2013.11.04]
A shot in the neck of local anesthesia may reduce hot flashes by as much as 50 percent for at least six months, a recent Northwestern Medicine® study found.
Published Studies Related to Americaine (Benzocaine)
Double-blind comparison of two types of benzocaine lozenges for the treatment of acute pharyngitis. 
In a reference-controlled double-blind trial in patients with acute pharyngitis the effects of a newly developed lozenge containing 8 mg of benzocaine (p-aminobenzoic acid ethyl ester, CAS 94-09-7) were compared with those of an identically dosed commercial pastille... The application of the benzocaine lozenges was statistically non-inferior to the use of the pastilles.
Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine. [2009.09]
PURPOSE: The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children... CONCLUSIONS: Application of Oraqix did not reduce discomfort when compared to benzocaine in this small sample size. Oraqix was more effective than benzocaine in the age group 9 and older. A larger sample size is needed to determine its efficacy in children younger than 9years old.
A study of benzocaine gel dosing for toothache. 
CONCLUSION: The improved dosing directions resulted in a high percentage of subjects self-applying an appropriate amount of benzocaine gel or matching placebo. The label and study methodology appear suitable for a pivotal dose-response study in subjects with toothache pain. While the current study was not statistically powered to make firm efficacy conclusions, 20% benzocaine gel appeared more efficacious than placebo, providing a rapid onset of pain relief and a relatively long duration of action.
Prospective randomized study of viscous lidocaine versus benzocaine in a GI cocktail for dyspepsia. [2004.07]
We hypothesized that Benzocaine (Hurricaine) would work as quickly and effectively as viscous Lidocaine in this preparation. This was a prospective randomized, single-blinded comparison between Benzocaine and Lidocaine as the topical anesthetic in a gastrointestinal (GI) cocktail... There were no adverse outcomes in either group.
Efficacy and tolerability of an intraoral benzocaine patch in the relief of spontaneous toothache pain. 
CONCLUSION: Although the results of the present study were promising, further research on this novel delivery system of benzocaine is warranted to firmly establish efficacy in patients with spontaneous toothache pain.
Clinical Trials Related to Americaine (Benzocaine)
Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel [Recruiting]
The project is a study comparing the effectiveness of two topical anesthetics for control of
pain associated with dental needle insertion in the palatal mucosa. A standard dental
topical anesthetic (20% benzocaine) will serve as an "active" control and will be compared
to a combination topical anesthetic, consisting of 20% lidocaine, 4% tetracaine and 2%
phenylephrine (TAC Alternate Gel, Compounding Arts Pharmacy, Lafayette, LA).
Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn [Not yet recruiting]
Frenotomy of tongue-tie is commonly performed to resolve breastfeeding difficulties, eg
maternal nipple pain and infant's latching difficulties. The procedure carries minor
discomfort for the infants. It is not known whether the use of topical benzocaine, a very
bitter tasting material' applied to the tongue-tie would decrease the length of cry. We will
measure the duration of crying in infants treated with topical benzocaine to the duration in
those not treated with the mediation.
Benzocaine Gel Toothache Dose-Response Study [Recruiting]
To evaluate the efficacy and safety of benzocaine gel products for the relief of toothache
and to assess the subject's compliance with proposed label directions.
Maintenance After Initiation of Nutrition TrAINing [Recruiting]
Obesity is the second leading cause of preventable deaths in the United States and is
associated with a wide range of diseases. In people who are obese, weight loss improves
blood pressure, dyslipidemia, glycemia, and arthritis symptoms; reduces medication use for
several disease processes; increases physical functioning; and enhances health-related
quality of life. The current study will evaluate a theoretically informed maintenance
intervention. If effective, this intervention could reduce the need for future clinic visits
to treat obesity and its many associated illnesses.
A Study to Investigate the Ability of GSK706769 to Maintain Clinical Remission After Withdrawal of Enbrel in Rheumatoid Arthritis Patients [Not yet recruiting]
The purpose of this study is to determine if GSK706769 can maintain clinical remission
established by Enbrel after withdrawal of Enbrel in rheumatoid arthritis patients.