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Amerge (Naratriptan Hydrochloride) - Summary

 
 



AMERGE SUMMARY

AMERGE Tablets contain naratriptan as the hydrochloride, which is a selective 5-hydroxytryptamine1 receptor subtype agonist.

AMERGE Tablets are indicated for the acute treatment of migraine attacks with or without aura in adults.

AMERGE Tablets are not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of AMERGE Tablets have not been established for cluster headache, which is present in an older, predominantly male population.


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NEWS HIGHLIGHTS

Media Articles Related to Amerge (Naratriptan)

Headaches in Women With Migraine Rise in Perimenopause
Source: Medscape NeurologyHeadlines [2016.02.03]
It's official: women with migraine experienced more frequent headaches during perimenopause than at other times, a new study shows.
Medscape Medical News

Technique helps predict likelihood of migraines in concussion patients
Source: Headache / Migraine News From Medical News Today [2016.02.02]
Researchers are using a mathematical tool to help determine which concussion patients will go on to suffer migraine headaches, according to a new study published online in the journal Radiology.

Avanir Pharmaceuticals announces FDA approval of ONZETRA Xsail (AVP-825) for the acute treatment of migraine in adults
Source: Headache / Migraine News From Medical News Today [2016.02.01]
Avanir Pharmaceuticals, Inc. has announced that the U.S. Food and Drug Administration (FDA) has approved ONZETRA™ Xsail™ (sumatriptan nasal powder), formerly known as AVP-825, for the...

Migraines May Worsen as Menopause Approaches
Source: MedicineNet Headache Specialty [2016.01.25]
Title: Migraines May Worsen as Menopause Approaches
Category: Health News
Created: 1/22/2016 12:00:00 AM
Last Editorial Review: 1/25/2016 12:00:00 AM

Migraines worsen as women approach menopause
Source: Headache / Migraine News From Medical News Today [2016.01.22]
Migraine headaches heat up as women approach menopause, according to a new study from researchers at the University of Cincinnati (UC), Montefiore Headache Center, Albert Einstein College of...

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Published Studies Related to Amerge (Naratriptan)

Published and not fully published double-blind, randomised, controlled trials with oral naratriptan in the treatment of migraine: a review based on the GSK Trial Register. [2011]
Naratriptan 2.5 mg is now an over-the-counter drug in Germany.Naratriptan, when available OTC is a reasonable second or third choice on the step care ladder in the acute treatment of migraine.

Efficacy of oral naratriptan in the treatment of menstrually related migraine. [2005.10]
The aim of this study was to investigate the efficacy of orally administered 2.5 mg naratriptan in the treatment of menstrually related migraine (MRM). A high percentage of women suffering from migraine report increased frequency of attacks in association with menstruation that may be more severe, of longer duration and more difficult to treat than at other times...

Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. [2003.11]
This was a randomized, double-blind study designed to evaluate the comparative efficacy and tolerability of the 40-mg dose of eletriptan and the 2.5-mg dose of naratriptan. Patients (n = 548) meeting International Headache Society (IHS) criteria for migraine were randomized to treat a single migraine attack with either eletriptan 40 mg, naratriptan 2.5 mg, or placebo.

Effects of naratriptan versus naproxen on daily functioning in the acute treatment of migraine: a randomized, double-blind, double-dummy, crossover study. [2003.09]
OBJECTIVE: To evaluate the effect of acute treatment on ictal behavioral functioning of patients with migraine via ambulatory accelerometry. BACKGROUND: The inability to carry out daily activities often complicates migraine attacks. Research into the effects of pharmacological drugs on this outcome parameter in the acute treatment of migraine has been based on subjective reports only... CONCLUSIONS: Consciously perceived clinical and subjective symptoms do not necessarily run in parallel with their behavioral equivalents. It, thus, may be important to assess the effects of treatment on behavioral functioning in the evaluation of the general efficacy of antimigraine drugs in the acute treatment of a migraine attack.

Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study. [2001.03]
OBJECTIVE: To determine the efficacy of naratriptan 1-mg and 2.5-mg tablets twice daily compared with placebo as short-term prophylaxis of menstrually associated migraine. BACKGROUND: Approximately 60% of women with migraine report headaches associated with their menstrual cycles. Results from an open-label study suggest that short-term administration of sumatriptan is useful in the prophylaxis of menstrually associated migraine... CONCLUSIONS: Naratriptan, 1 mg, with tolerability similar to placebo, is an effective, short-term, prophylactic treatment for menstrually associated migraine.

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Clinical Trials Related to Amerge (Naratriptan)

Special Drug Use Investigation for AMERGEŽ Tablet (Long-term) [Completed]
To investigate the long-term safety and efficacy of AMERGE (naratriptan hydrochloride) on Japanese patients with migraine headache in clinical setting

Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction [Terminated]
The purpose of this study is to determine whether naratriptan, a medication approved for treatment of migraine, is effective in the treatment of post traumatic headache associated with cognitive dysfunction.

Drug Use Investigation for AMERGE (Naratriptan Hydrochloride) Tablet [Completed]
The study is designed to investigate the information on safety and efficacy of naratriptan tablets on Japanese subjects with migraine headache during Japanese post-marketing surveillance period.

Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine. [Not yet recruiting]
The purpose of this study is to determine whether a fixed-dose combination of naratriptan 2,5 mg + naproxen 500 mg is effective and safe compared each monotherapy for the acute treatment of migraine.

Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine [Not yet recruiting]
The purpose of this study is to determine whether a fixed-dose combination of naratriptan + naproxen is effective compared each monotherapy for the acute treatment of migraine.

more trials >>

Reports of Suspected Amerge (Naratriptan) Side Effects

Overdose (5)Drug Ineffective (4)Chest Pain (4)Stress Cardiomyopathy (4)Photophobia (3)Cataract (3)Troponin T Increased (3)Eye Pain (3)Brain Natriuretic Peptide Increased (3)Vasospasm (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Amerge has an overall score of 8. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Amerge review by 48 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   migraines
Dosage & duration:   2.5mg taken 3-4 times per week for the period of 6 yrs
Other conditions:   high blood pressure
Other drugs taken:   atenolol, hydrochlorothiazide, lisinopril
  
Reported Results
Benefits:   Amerge is effective in reducing the pain and associated symptoms of migraines.
Side effects:   Mild drowsiness, sometimes mild nausea.
Comments:   I have very severe migraine disease and have tried many different treatments. None are effective 100% of the time. In my experience, Amerge is the most effective for mild and moderate migraines (Nothing seems to work for severe attacks). I prefer Amerge because the beneficial effects seem to last longer than many of the other anti-migraine meds (often 18-24 hrs.). Also, side effects seem to be negligible(No palpitations and dizziness like with imitrex). The downside is that Amerge takes longer to work (2-4 hrs) than the other triptans. But because of the better safety profile and the longer duration of effectiveness, for me Amerge is a top choice for migraines.

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Page last updated: 2016-02-03

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