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Amerge (Naratriptan Hydrochloride) - Summary

 
 



AMERGE SUMMARY

AMERGE Tablets contain naratriptan as the hydrochloride, which is a selective 5-hydroxytryptamine1 receptor subtype agonist.

AMERGE Tablets are indicated for the acute treatment of migraine attacks with or without aura in adults.

AMERGE Tablets are not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of AMERGE Tablets have not been established for cluster headache, which is present in an older, predominantly male population.


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NEWS HIGHLIGHTS

Media Articles Related to Amerge (Naratriptan)

Positive data presented demonstrating erenumab significantly reduces monthly migraine days in patients with chronic migraine
Source: Clinical Trials / Drug Trials News From Medical News Today [2016.09.20]
Amgen has announced detailed global Phase 2 results showing erenumab demonstrated a statistically significant reduction in monthly migraine days compared with placebo in patients with chronic...

Sound Waves: An Rx for High Blood Pressure, Migraine?
Source: MedicineNet Clinical Trials Specialty [2016.09.19]
Title: Sound Waves: An Rx for High Blood Pressure, Migraine?
Category: Health News
Created: 9/16/2016 12:00:00 AM
Last Editorial Review: 9/19/2016 12:00:00 AM

Innovative sound therapy treats hypertension and migraine
Source: Headache / Migraine News From Medical News Today [2016.09.17]
A groundbreaking device that aligns the left and right brain using sound alone may reduce the symptoms of migraine, hypertension, and insomnia.

Spiritual meditation plus medication: The best medicine for migraines?
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2016.09.05]
"Effect of Different Meditation Types on Migraine Headache Medication Use," an article published in Behavioral Medicine, examines whether or not, and to what extent, a combination of spiritual...

Research on an fMRI-Based Neurologic Signature of Physical Pain to be Presented at Upcoming 10th Annual Pain & Migraine Therapeutics Summit
Source: Conferences News From Medical News Today [2016.08.16]
As persistent pain is solely measured by self-report, research is currently being conducted to find objective methods of identifying physical pain in the brain.

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Published Studies Related to Amerge (Naratriptan)

Published and not fully published double-blind, randomised, controlled trials with oral naratriptan in the treatment of migraine: a review based on the GSK Trial Register. [2011]
Naratriptan 2.5 mg is now an over-the-counter drug in Germany.Naratriptan, when available OTC is a reasonable second or third choice on the step care ladder in the acute treatment of migraine.

Efficacy of oral naratriptan in the treatment of menstrually related migraine. [2005.10]
The aim of this study was to investigate the efficacy of orally administered 2.5 mg naratriptan in the treatment of menstrually related migraine (MRM). A high percentage of women suffering from migraine report increased frequency of attacks in association with menstruation that may be more severe, of longer duration and more difficult to treat than at other times...

Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. [2003.11]
This was a randomized, double-blind study designed to evaluate the comparative efficacy and tolerability of the 40-mg dose of eletriptan and the 2.5-mg dose of naratriptan. Patients (n = 548) meeting International Headache Society (IHS) criteria for migraine were randomized to treat a single migraine attack with either eletriptan 40 mg, naratriptan 2.5 mg, or placebo.

Effects of naratriptan versus naproxen on daily functioning in the acute treatment of migraine: a randomized, double-blind, double-dummy, crossover study. [2003.09]
OBJECTIVE: To evaluate the effect of acute treatment on ictal behavioral functioning of patients with migraine via ambulatory accelerometry. BACKGROUND: The inability to carry out daily activities often complicates migraine attacks. Research into the effects of pharmacological drugs on this outcome parameter in the acute treatment of migraine has been based on subjective reports only... CONCLUSIONS: Consciously perceived clinical and subjective symptoms do not necessarily run in parallel with their behavioral equivalents. It, thus, may be important to assess the effects of treatment on behavioral functioning in the evaluation of the general efficacy of antimigraine drugs in the acute treatment of a migraine attack.

Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study. [2001.03]
OBJECTIVE: To determine the efficacy of naratriptan 1-mg and 2.5-mg tablets twice daily compared with placebo as short-term prophylaxis of menstrually associated migraine. BACKGROUND: Approximately 60% of women with migraine report headaches associated with their menstrual cycles. Results from an open-label study suggest that short-term administration of sumatriptan is useful in the prophylaxis of menstrually associated migraine... CONCLUSIONS: Naratriptan, 1 mg, with tolerability similar to placebo, is an effective, short-term, prophylactic treatment for menstrually associated migraine.

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Clinical Trials Related to Amerge (Naratriptan)

Special Drug Use Investigation for AMERGEŽ Tablet (Long-term) [Completed]
To investigate the long-term safety and efficacy of AMERGE (naratriptan hydrochloride) on Japanese patients with migraine headache in clinical setting

Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction [Terminated]
The purpose of this study is to determine whether naratriptan, a medication approved for treatment of migraine, is effective in the treatment of post traumatic headache associated with cognitive dysfunction.

Drug Use Investigation for AMERGE (Naratriptan Hydrochloride) Tablet [Completed]
The study is designed to investigate the information on safety and efficacy of naratriptan tablets on Japanese subjects with migraine headache during Japanese post-marketing surveillance period.

Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine. [Not yet recruiting]
The purpose of this study is to determine whether a fixed-dose combination of naratriptan 2,5 mg + naproxen 500 mg is effective and safe compared each monotherapy for the acute treatment of migraine.

Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine [Not yet recruiting]
The purpose of this study is to determine whether a fixed-dose combination of naratriptan + naproxen is effective compared each monotherapy for the acute treatment of migraine.

more trials >>

Reports of Suspected Amerge (Naratriptan) Side Effects

Overdose (5)Drug Ineffective (4)Chest Pain (4)Stress Cardiomyopathy (4)Photophobia (3)Cataract (3)Troponin T Increased (3)Eye Pain (3)Brain Natriuretic Peptide Increased (3)Vasospasm (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Amerge has an overall score of 8. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Amerge review by 48 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   migraines
Dosage & duration:   2.5mg taken 3-4 times per week for the period of 6 yrs
Other conditions:   high blood pressure
Other drugs taken:   atenolol, hydrochlorothiazide, lisinopril
  
Reported Results
Benefits:   Amerge is effective in reducing the pain and associated symptoms of migraines.
Side effects:   Mild drowsiness, sometimes mild nausea.
Comments:   I have very severe migraine disease and have tried many different treatments. None are effective 100% of the time. In my experience, Amerge is the most effective for mild and moderate migraines (Nothing seems to work for severe attacks). I prefer Amerge because the beneficial effects seem to last longer than many of the other anti-migraine meds (often 18-24 hrs.). Also, side effects seem to be negligible(No palpitations and dizziness like with imitrex). The downside is that Amerge takes longer to work (2-4 hrs) than the other triptans. But because of the better safety profile and the longer duration of effectiveness, for me Amerge is a top choice for migraines.

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Page last updated: 2016-09-20

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