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Amerge (Naratriptan Hydrochloride) - Summary



AMERGE Tablets contain naratriptan as the hydrochloride, which is a selective 5-hydroxytryptamine1 receptor subtype agonist.

AMERGE Tablets are indicated for the acute treatment of migraine attacks with or without aura in adults.

AMERGE Tablets are not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of AMERGE Tablets have not been established for cluster headache, which is present in an older, predominantly male population.

See all Amerge indications & dosage >>


Media Articles Related to Amerge (Naratriptan)

Migraine, Carpal Tunnel Syndrome Linked in Association Study
Source: MedPage Today Neurology [2015.05.15]
(MedPage Today) -- But a mechanistic connection remains unclear.

Morning Break: Guarding Family Jewels, Migraine in Teens, Birds Go Viral
Source: MedPage Today OB/Gyn [2015.05.15]
(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff.

Migraine Headache
Source: MedicineNet Antiphospholipid Syndrome Specialty [2015.05.14]
Title: Migraine Headache
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/14/2015 12:00:00 AM

UT Southwestern plastic surgeons identify link between migraines and carpal tunnel syndrome
Source: Bones / Orthopedics News From Medical News Today [2015.04.29]
Plastic surgeons at UT Southwestern Medical Center have demonstrated for the first time an association between migraines and carpal tunnel syndrome, with migraines more than twice as prevalent in...

Clinical trial results of potential migraine therapy to be presented by Achelios Therapeutics
Source: Headache / Migraine News From Medical News Today [2015.04.21]
TOPOFEN (TM) is a new and novel topical medication for the treatment of acute migraineAchelios Therapeutics will announce results from a Phase IIa placebo-controlled clinical trial in moderate...

more news >>

Published Studies Related to Amerge (Naratriptan)

Published and not fully published double-blind, randomised, controlled trials with oral naratriptan in the treatment of migraine: a review based on the GSK Trial Register. [2011]
Naratriptan 2.5 mg is now an over-the-counter drug in Germany.Naratriptan, when available OTC is a reasonable second or third choice on the step care ladder in the acute treatment of migraine.

Efficacy of oral naratriptan in the treatment of menstrually related migraine. [2005.10]
The aim of this study was to investigate the efficacy of orally administered 2.5 mg naratriptan in the treatment of menstrually related migraine (MRM). A high percentage of women suffering from migraine report increased frequency of attacks in association with menstruation that may be more severe, of longer duration and more difficult to treat than at other times...

Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. [2003.11]
This was a randomized, double-blind study designed to evaluate the comparative efficacy and tolerability of the 40-mg dose of eletriptan and the 2.5-mg dose of naratriptan. Patients (n = 548) meeting International Headache Society (IHS) criteria for migraine were randomized to treat a single migraine attack with either eletriptan 40 mg, naratriptan 2.5 mg, or placebo.

Effects of naratriptan versus naproxen on daily functioning in the acute treatment of migraine: a randomized, double-blind, double-dummy, crossover study. [2003.09]
OBJECTIVE: To evaluate the effect of acute treatment on ictal behavioral functioning of patients with migraine via ambulatory accelerometry. BACKGROUND: The inability to carry out daily activities often complicates migraine attacks. Research into the effects of pharmacological drugs on this outcome parameter in the acute treatment of migraine has been based on subjective reports only... CONCLUSIONS: Consciously perceived clinical and subjective symptoms do not necessarily run in parallel with their behavioral equivalents. It, thus, may be important to assess the effects of treatment on behavioral functioning in the evaluation of the general efficacy of antimigraine drugs in the acute treatment of a migraine attack.

Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study. [2001.03]
OBJECTIVE: To determine the efficacy of naratriptan 1-mg and 2.5-mg tablets twice daily compared with placebo as short-term prophylaxis of menstrually associated migraine. BACKGROUND: Approximately 60% of women with migraine report headaches associated with their menstrual cycles. Results from an open-label study suggest that short-term administration of sumatriptan is useful in the prophylaxis of menstrually associated migraine... CONCLUSIONS: Naratriptan, 1 mg, with tolerability similar to placebo, is an effective, short-term, prophylactic treatment for menstrually associated migraine.

more studies >>

Clinical Trials Related to Amerge (Naratriptan)

Sumatriptan and Naratriptan Pregnancy Registry [Recruiting]
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However, the peak prevalence of migraine is in women of childbearing age. This, coupled with the sporadic nature of migraine attacks and high rates of unplanned pregnancies, makes unintentional exposure to anti-migraine medications during pregnancy likely. Prior to an anti-migraine medication being marketed there are few data available on drug safety in pregnancy: data from animal models may not translate directly to humans and pregnant women are routinely excluded from clinical trials. The Sumatriptan Pregnancy Registry was established by GlaxoSmithKline (GSK) in 1996 to monitor the safety of sumatriptan during pregnancy. It was combined with the Naratriptan Pregnancy Registry in 2001 and data collection on the sumatriptan-naproxen combination (Treximet) began in 2008.

Naratriptan for the Treatment of Post Traumatic Headache Associated With Cognitive Dysfunction [Recruiting]
The purpose of this study is to determine whether naratriptan, a medication approved for treatment of migraine, is effective in the treatment of post traumatic headache associated with cognitive dysfunction.

Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine. [Not yet recruiting]
The purpose of this study is to determine whether a fixed-dose combination of naratriptan 2,5 mg + naproxen 500 mg is effective and safe compared each monotherapy for the acute treatment of migraine.

Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine [Not yet recruiting]
The purpose of this study is to determine whether a fixed-dose combination of naratriptan + naproxen is effective compared each monotherapy for the acute treatment of migraine.

Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order [Recruiting]
In a double blind randomized clinical trial with cross-over design, treatment using naratriptan will be compared to placebo within a group of 30 convicts with psychiatric disorders such as psychosis or psychopathy with repeated aggressive outbursts resistant to conventional psychopharmacologic and other psychotherapeutic treatment. Hypothesis is that

addition of naratriptan to the individual treatment regime reduces aggression - and improves

general outcome- as compared to addition of placebo and is well tolerated in this group and under these conditions.

more trials >>

Reports of Suspected Amerge (Naratriptan) Side Effects

Overdose (5)Drug Ineffective (4)Chest Pain (4)Stress Cardiomyopathy (4)Photophobia (3)Cataract (3)Troponin T Increased (3)Eye Pain (3)Brain Natriuretic Peptide Increased (3)Vasospasm (3)more >>


Based on a total of 1 ratings/reviews, Amerge has an overall score of 8. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.

Amerge review by 48 year old male patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   migraines
Dosage & duration:   2.5mg taken 3-4 times per week for the period of 6 yrs
Other conditions:   high blood pressure
Other drugs taken:   atenolol, hydrochlorothiazide, lisinopril
Reported Results
Benefits:   Amerge is effective in reducing the pain and associated symptoms of migraines.
Side effects:   Mild drowsiness, sometimes mild nausea.
Comments:   I have very severe migraine disease and have tried many different treatments. None are effective 100% of the time. In my experience, Amerge is the most effective for mild and moderate migraines (Nothing seems to work for severe attacks). I prefer Amerge because the beneficial effects seem to last longer than many of the other anti-migraine meds (often 18-24 hrs.). Also, side effects seem to be negligible(No palpitations and dizziness like with imitrex). The downside is that Amerge takes longer to work (2-4 hrs) than the other triptans. But because of the better safety profile and the longer duration of effectiveness, for me Amerge is a top choice for migraines.

See all Amerge reviews / ratings >>

Page last updated: 2015-05-15

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